| Disease Name: |
Localized insulin-derived Amyloidosis |
| ISA Name: |
AIns Amyloidosis
|
| Alternative Names: |
- Injection-localized amyloidosis
- Localized A-Ins amyloidosis
- Ains-derived amyloidosis
- Insulin-derived amyloidosis
- LIDA
|
| MeSH Description: |
No information available
|
| Type: |
Amyloidosis
|
| ICD-10 Classification |
Amyloidosis
|
| Tissue: |
Insulin injection site
|
| Precursor Proteins: |
| Primary Name: |
Insulin
|
| Gene Name: |
INS
|
| Alternative Protein Names: |
Insulin [Cleaved into: Insulin B chain; Insulin A chain]
|
| ISA Nomenclature: |
AIns
|
| Protein Length: |
110
|
| Precursor Protein Sequence: |
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
|
| UniProt AC: |
P01308
|
| UniProt ID: |
INS_HUMAN
|
| AmyPro: |
AP00023
|
|
| Co-deposited Proteins: |
| Primary Name: |
Apolipoprotein A-I
|
| Gene Name: |
APOA1
|
| Association Source: |
24446896
|
| Protein Names: |
Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]
|
| Protein Length: |
267
|
| Protein Sequence: |
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
|
| UniProt AC: |
P02647
|
| UniProt ID: |
APOA1_HUMAN
|
| Primary Name: |
Apolipoprotein E
|
| Gene Name: |
APOE
|
| Association Source: |
24446896
|
| Protein Names: |
Apolipoprotein E (Apo-E)
|
| Protein Length: |
317
|
| Protein Sequence: |
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
|
| UniProt AC: |
P02649
|
| UniProt ID: |
APOE_HUMAN
|
| Primary Name: |
Serum amyloid P-component
|
| Gene Name: |
APCS
|
| Association Source: |
19683329
|
| Protein Names: |
Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]
|
| Protein Length: |
223
|
| Protein Sequence: |
MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV
|
| UniProt AC: |
P02743
|
| UniProt ID: |
SAMP_HUMAN
|
| Primary Name: |
Apolipoprotein A-IV
|
| Gene Name: |
APOA4
|
| Association Source: |
24446896
|
| Protein Names: |
Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4)
|
| Protein Length: |
396
|
| Protein Sequence: |
MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
|
| UniProt AC: |
P06727
|
| UniProt ID: |
APOA4_HUMAN
|
|
