Disease Name:
Thyroid Cancer, Medullary
ISA Name:
ACal Amyloidosis
Alternative Names:
Medullary thyroid cancer (MTC)
Thyroid carcinoma, medullary
Medullary Carcinoma of the Thyroid (MCT)
Medullary Thyroid Carcinoma
Thyroid carcinoma, Familial medullary
Familial medullary thyroid carcinoma
FMTC
MTC1
MeSH Description:
A neuroendocrine carcinoma that originates in the c-cells of the thyroid gland; about 10-20% of cases are familial. It occurs sporadically or is associated with multiple endocrine neoplasia syndromes. Germline and somatic mutations in RET and NTRK1 genes have been identified.
Type:
Amyloidosis
ICD-10 Classification
Neoplasms
Tissue:
C-cell thyroid tumors
Precursor Proteins:
P01258: Calcitonin
Primary Name:
Calcitonin
Gene Name:
CALCA
Alternative Protein Names:
Calcitonin [Cleaved into: Calcitonin; Katacalcin (Calcitonin carboxyl-terminal peptide) (CCP) (PDN-21)]
ISA Nomenclature:
ACal
Protein Length:
141
Precursor Protein Sequence:
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQNYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN
UniProt AC:
P01258
UniProt ID:
CALC_HUMAN
AmyPro:
AP00002
Co-deposited Proteins:
P02649: Apolipoprotein E
Primary Name:
Apolipoprotein E
Gene Name:
APOE
Association Source:
26304852
Protein Names:
Apolipoprotein E (Apo-E)
Protein Length:
317
Protein Sequence:
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
UniProt AC:
P02649
UniProt ID:
APOE_HUMAN
P02743: Serum amyloid P-component
Primary Name:
Serum amyloid P-component
Gene Name:
APCS
Association Source:
56421
Protein Names:
Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]
Protein Length:
223
Protein Sequence:
MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV
UniProt AC:
P02743
UniProt ID:
SAMP_HUMAN
P05060: Secretogranin-1
Primary Name:
Secretogranin-1
Gene Name:
CHGB
Association Source:
26304852
Protein Names:
Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide]
Protein Length:
677
Protein Sequence:
MQPTLLLSLLGAVGLAAVNSMPVDNRNHNEGMVTRCIIEVLSNALSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSSHHTAEKRKRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEYNYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEEPVSTHQEAENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEKFSQRG
UniProt AC:
P05060
UniProt ID:
SCG1_HUMAN
P06727: Apolipoprotein A-IV
Primary Name:
Apolipoprotein A-IV
Gene Name:
APOA4
Association Source:
26304852
Protein Names:
Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4)
Protein Length:
396
Protein Sequence:
MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
UniProt AC:
P06727
UniProt ID:
APOA4_HUMAN
P10092: Calcitonin gene-related peptide 2
Primary Name:
Calcitonin gene-related peptide 2
Gene Name:
CALCB
Association Source:
26304852
Protein Names:
Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
Protein Length:
127
Protein Sequence:
MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRRRDLQA
UniProt AC:
P10092
UniProt ID:
CALCB_HUMAN