AmyCo

The Amyloidoses Collection

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Basic Information

Disease Name:

AHL Amyloidosis

ISA Name:

AHL Amyloidosis

Alternative Names:

Heavy/light-chain amyloidosis
Heavy- and light-chain amyloidosis
Immunoglobulin Heavy and Light Chain Amyloidosis

MeSH Description:

No information available

Type:

Amyloidosis

ICD-10 Classification

Amyloidosis

Tissue:

Lung, Kidney, Heart

Precursor Proteins:

Primary Name:	Immunoglobulin epsilon heavy chain
Gene Name:	IGE
Alternative Protein Names:	Immunoglobulin epsilon heavy chain (Immunoglobulin epsilon heavy chain ND)
ISA Nomenclature:	AH
Protein Length:	547
Precursor Protein Sequence:	QVQLVQSGAEVRKPGASVRVSCKASGYTFIDSYVGWIRQAPGHGLEWIHWINPNSGGTNYAPRFQGRVTMTRDASFSTAYMDLRSLRSDDSAVFYCAKSDPFWSDYNFDYSSSEEGTEVTYTVSGAWTLPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTVDNKTFSVCSRDFTPPTVKILQSSCDGLGHFPPTIQLCLVSGYTPGTINITWLEDGQVMDVDLSTASTESQGELASTESQLTLSQKHWLSDRTYTCQVTYQGHTFQDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWQEKDEFICRAVHEAASPSQTVQRAVSVNPGK
UniProt AC:	P0DOX4
UniProt ID:	IGE_HUMAN
AmyPro:

Primary Name:	Immunoglobulin gamma-1 heavy chain
Gene Name:	IGG1
Alternative Protein Names:	Immunoglobulin gamma-1 heavy chain (Immunoglobulin gamma-1 heavy chain NIE)
ISA Nomenclature:	AH
Protein Length:	449
Precursor Protein Sequence:	QVQLVQSGGGVVQPGRSLRLSCAASGFTFSRYTIHWVRQAPGKGLEWVAVMSYBGBBKHYADSVNGRFTISRNDSKNTLYLNMNSLRPEDTAVYYCARIRDTAMFFAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
UniProt AC:	P0DOX5
UniProt ID:	IGG1_HUMAN
AmyPro:

Primary Name:	Immunoglobulin mu heavy chain
Gene Name:	IGM
Alternative Protein Names:	Immunoglobulin mu heavy chain (Immunoglobulin mu heavy chain OU)
ISA Nomenclature:	AH
Protein Length:	576
Precursor Protein Sequence:	QVTLTESGPALVKPKQPLTLTCTFSGFSLSTSRMRVSWIRRPPGKALEWLARIDDDDKFYWSTSLRTRLSISKNDSKNQVVLIMINVNPVDTATYYCARVVNSVMAGYYYYYMDVWGKGTTVTVSSGSASAPTLFPLVSCENSBPSSTVAVGCLAQDFLPDSITFSWKYNQSQKISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVCKWVQHPNGNKQKNVPLPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQVWSLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGESMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTREENGAVKTHTNISESHPNATFSAVGEASICEDDDWSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGEPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGQTYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY
UniProt AC:	P0DOX6
UniProt ID:	IGM_HUMAN
AmyPro:

Primary Name:	Immunoglobulin kappa light chain
Gene Name:	IGK
Alternative Protein Names:	Immunoglobulin kappa light chain (Immunoglobulin kappa light chain EU)
ISA Nomenclature:	AL
Protein Length:	214
Precursor Protein Sequence:	DIQMTQSPSTLSASVGDRVTITCRASQSINTWLAWYQQKPGKAPKLLMYKASSLESGVPSRFIGSGSGTEFTLTISSLQPDDFATYYCQQYNSDSKMFGQGTKVEVKGTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
UniProt AC:	P0DOX7
UniProt ID:	IGK_HUMAN
AmyPro:

Primary Name:	Immunoglobulin lambda-1 light chain
Gene Name:	IGL1
Alternative Protein Names:	Immunoglobulin lambda-1 light chain (Immunoglobulin lambda-1 light chain MCG)
ISA Nomenclature:	AL
Protein Length:	216
Precursor Protein Sequence:	QSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNFVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
UniProt AC:	P0DOX8
UniProt ID:	IGL1_HUMAN
AmyPro:

Primary Name:	Immunoglobulin alpha-2 heavy chain
Gene Name:	IGA2
Alternative Protein Names:	Immunoglobulin alpha-2 heavy chain (Immunoglobulin alpha-2 heavy chain BUT)
ISA Nomenclature:	AH
Protein Length:	455
Precursor Protein Sequence:	EVQLVETGGGLIQPGGSLRLSCAASGFTVSNHSMSWVRQAPGKALEWVSAIYRGGTTYYADSVKGRFTISRDDSRNTVYLQMNSLRAEDTAVYYCARDLAAARLFGKGTTVTVSSASPTSPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNSSQDVTVPCRVPPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVEGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTYAVTSILRVAAEDWKKGETFSCMVGHEALPLAFTQKTIDRLAGKPTHINVSVVMAEADGTCY
UniProt AC:	P0DOX2
UniProt ID:	IGA2_HUMAN
AmyPro:

Co-deposited Proteins:

Primary Name:	Apolipoprotein E
Gene Name:	APOE
Association Source:	25796445
Protein Names:	Apolipoprotein E (Apo-E)
Protein Length:	317
Protein Sequence:	MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
UniProt AC:	P02649
UniProt ID:	APOE_HUMAN

Primary Name:	Serum amyloid P-component
Gene Name:	APCS
Association Source:	25796445
Protein Names:	Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]
Protein Length:	223
Protein Sequence:	MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV
UniProt AC:	P02743
UniProt ID:	SAMP_HUMAN

Interaction Network

Right click on Protein Nodes to go to UniProt.
Red Colored Edges indicate a connection between the disease and a precursor protein, while Blue Colored Edges indicate a connection with co-deposited proteins

Cross-References

MeSH:
ICD:
OMIM:
PubMed:

National and Kapodistrian University of Athens

Department of Biology

Biophysics & Bioinformatics Laboratory

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