AmyCo

Basic Information

Disease Name:

Insomnia, Fatal Familial

ISA Name:

APrP Amyloidosis

Alternative Names:

Familial Fatal Insomnia
Insomnia Familial Fatal
Fatal Familial Disease

MeSH Description:

An autosomal dominant disorder characterized by degeneration of the thalamus and progressive insomnia. It is caused by a mutation in the prion protein (prions).

Type:

Amyloidosis

ICD-10 Classification

Certain Infectious and Parasitic Diseases

Tissue:

Central Nervous System (CNS)

Precursor Proteins:

Primary Name:	Major prion protein
Gene Name:	PRNP
Alternative Protein Names:	Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)
ISA Nomenclature:	APrP
Protein Length:	253
Precursor Protein Sequence:	MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
UniProt AC:	P04156
UniProt ID:	PRIO_HUMAN
AmyPro:	AP00008

Co-deposited Proteins:

No information available

Interaction Network

Right click on Protein Nodes to go to UniProt.
Red Colored Edges indicate a connection between the disease and a precursor protein, while Blue Colored Edges indicate a connection with co-deposited proteins

MeSH:
ICD:
OMIM:
PubMed:

Protein Information