Disease Name:
Waldenstrom Macroglobulinemia
Alternative Names:
Familial Waldenstrom's Macroglobulinaemia
Lymphoma, Lymphocytic, Plasmacytoid
Lymphoma, Lymphoplasmacytoid
Macroglobulinemia
Primary Macroglobulinemia
Waldenstrom's Macroglobulinaemia
Waldenstrom's Macroglobulinemia
MeSH Description:
A lymphoproliferative disorder characterized by pleomorphic B-lymphocytes including plasma cells, with increased levels of monoclonal serum immunoglobulin M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include anemia; hemorrhages; and hyperviscosity.
Type:
Clinical condition associated with amyloidosis
ICD-10 Classification
Neoplasms
Tissue:
Kidney, Blood Vessel, Liver
Associated Amyloidosis:
Immunoglobulin Light-chain Amyloidosis AA Amyloidosis Wild type beta-2-microglobulin-related Amyloidosis
Precursor Proteins:
P0DJI8: Serum amyloid A-1 protein
Primary Name:
Serum amyloid A-1 protein
Gene Name:
SAA1
Alternative Protein Names:
Serum amyloid A-1 protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(2-103); Serum amyloid protein A(2-102); Serum amyloid protein A(4-101)]
ISA Nomenclature:
AA
Protein Length:
122
Precursor Protein Sequence:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt AC:
P0DJI8
UniProt ID:
SAA1_HUMAN
AmyPro:
AP00005
P0DJI9: Serum amyloid A-2 protein
Primary Name:
Serum amyloid A-2 protein
Gene Name:
SAA2
Alternative Protein Names:
Serum amyloid A-2 protein (SAA2)
ISA Nomenclature:
AA
Protein Length:
122
Precursor Protein Sequence:
MKLLTGLVFCSLVLSVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVISNARENIQRLTGRGAEDSLADQAANKWGRSGRDPNHFRPAGLPEKY
UniProt AC:
P0DJI9
UniProt ID:
SAA2_HUMAN
AmyPro:
P61769: Beta-2-microglobulin
Primary Name:
Beta-2-microglobulin
Gene Name:
B2M
Alternative Protein Names:
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
ISA Nomenclature:
Aß2M
Protein Length:
119
Precursor Protein Sequence:
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
UniProt AC:
P61769
UniProt ID:
B2MG_HUMAN
AmyPro:
AP00017
P0DOX7: Immunoglobulin kappa light chain
Primary Name:
Immunoglobulin kappa light chain
Gene Name:
IGK
Alternative Protein Names:
Immunoglobulin kappa light chain (Immunoglobulin kappa light chain EU)
ISA Nomenclature:
AL
Protein Length:
214
Precursor Protein Sequence:
DIQMTQSPSTLSASVGDRVTITCRASQSINTWLAWYQQKPGKAPKLLMYKASSLESGVPSRFIGSGSGTEFTLTISSLQPDDFATYYCQQYNSDSKMFGQGTKVEVKGTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
UniProt AC:
P0DOX7
UniProt ID:
IGK_HUMAN
AmyPro:
P0DOX8: Immunoglobulin lambda-1 light chain
Primary Name:
Immunoglobulin lambda-1 light chain
Gene Name:
IGL1
Alternative Protein Names:
Immunoglobulin lambda-1 light chain (Immunoglobulin lambda-1 light chain MCG)
ISA Nomenclature:
AL
Protein Length:
216
Precursor Protein Sequence:
QSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNFVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
UniProt AC:
P0DOX8
UniProt ID:
IGL1_HUMAN
AmyPro:
Co-deposited Proteins:
No information available
