AmyCo

Basic Information

Disease Name:

Kuru

ISA Name:

APrP Amyloidosis

Alternative Names:

Encephalopathy, Kuru
Kuru Encephalopathy

MeSH Description:

A prion disease found exclusively among the Fore linguistic group natives of the highlands of New Guinea. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques.

Type:

Amyloidosis

ICD-10 Classification

Certain Infectious and Parasitic Diseases

Tissue:

Central Nervous System (CNS)

Precursor Proteins:

Primary Name:	Major prion protein
Gene Name:	PRNP
Alternative Protein Names:	Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)
ISA Nomenclature:	APrP
Protein Length:	253
Precursor Protein Sequence:	MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
UniProt AC:	P04156
UniProt ID:	PRIO_HUMAN
AmyPro:	AP00008

Co-deposited Proteins:

No information available

MeSH:
ICD:
OMIM:
PubMed:

Protein Information