AmyCo

Basic Information

Disease Name:

Periodic fever, familial, autosomal dominant

Alternative Names:

Autosomal Dominant Familial Periodic Fever
Familial Hibernian fever
Hibernian Familial Fever
Hibernian fever, familial
TNF Receptor-associated Periodic Syndrome
Tumor necrosis factor receptor-associated periodic syndrome
TRAPS
TRAPS syndrome
Tumor necrosis factor receptor 1 associated periodic syndrome
TNF receptor 1-associated periodic syndrome
FPF
FHF

MeSH Description:

An inherited condition characterized by recurrent episodes of fever; onset is typically in early childhood. Fevers usually persist for about three weeks, though they can be longer or shorter, and may not occur again for several weeks or several years. Other symptoms may include abdominal pain; myalgia; arthralgia; skin rash and systemic inflammation; amyloidosis may also occur in some cases. There is often no trigger, but episodes are sometimes preceded by infections, injury, or stress. Germline mutations in the TNFRSFIA gene have been identified.

Type:

Clinical condition associated with amyloidosis

ICD-10 Classification

Diseases of the Musculoskeletal System and Connective Tissue

Tissue:

Kidney

Associated Amyloidosis:

AA Amyloidosis

Precursor Proteins:

Primary Name:	Serum amyloid A-1 protein
Gene Name:	SAA1
Alternative Protein Names:	Serum amyloid A-1 protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(2-103); Serum amyloid protein A(2-102); Serum amyloid protein A(4-101)]
ISA Nomenclature:	AA
Protein Length:	122
Precursor Protein Sequence:	MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt AC:	P0DJI8
UniProt ID:	SAA1_HUMAN
AmyPro:	AP00005

Primary Name:	Serum amyloid A-2 protein
Gene Name:	SAA2
Alternative Protein Names:	Serum amyloid A-2 protein (SAA2)
ISA Nomenclature:	AA
Protein Length:	122
Precursor Protein Sequence:	MKLLTGLVFCSLVLSVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVISNARENIQRLTGRGAEDSLADQAANKWGRSGRDPNHFRPAGLPEKY
UniProt AC:	P0DJI9
UniProt ID:	SAA2_HUMAN
AmyPro:

Co-deposited Proteins:

No information available

MeSH:
ICD:
OMIM:
PubMed:

Protein Information

Protein Information