| Disease Name: |
PrP Systemic Amyloidosis |
| ISA Name: |
APrP Amyloidosis
|
| Alternative Names: |
- Prion protein systemic amyloidosis
- Chronic diarrhea with HSAN
- Chronic diarrhea with hereditary sensory and autonomic neuropathy
- Prion Disease Associated with Diarrhea and Autonomic Neuropathy
|
| MeSH Description: |
No information available
|
| Type: |
Amyloidosis
|
| ICD-10 Classification |
Diseases of the Nervous System
|
| Tissue: |
Peripheral Nervous System (PNS), Kidney, Liver, Lung
|
| Precursor Proteins: |
| Primary Name: |
Major prion protein
|
| Gene Name: |
PRNP
|
| Alternative Protein Names: |
Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)
|
| ISA Nomenclature: |
APrP
|
| Protein Length: |
253
|
| Precursor Protein Sequence: |
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
|
| UniProt AC: |
P04156
|
| UniProt ID: |
PRIO_HUMAN
|
| AmyPro: |
No information available |
|
| Co-deposited Proteins: |
| Primary Name: |
Serum amyloid P-component
|
| Gene Name: |
APCS
|
| Association Source: |
24224623
|
| Protein Names: |
Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]
|
| Protein Length: |
223
|
| Protein Sequence: |
MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV
|
| UniProt AC: |
P02743
|
| UniProt ID: |
SAMP_HUMAN
|
|
