AmyCo

Basic Information

Disease Name:

Sjogren's Syndrome

Alternative Names:

Sicca Syndrome
Sjogren Syndrome
SS

MeSH Description:

Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both keratoconjunctivitis sicca and xerostomia. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.

Type:

Clinical condition associated with amyloidosis

ICD-10 Classification

Diseases of the Musculoskeletal System and Connective Tissue

Tissue:

Lung, Skin, Kidney, Salivary Gland, Soft Tissues, Lachrymal Gland

Associated Amyloidosis:

Immunoglobulin Light-chain Amyloidosis
Wild-type transthyretin-related Amyloidosis
Amyloidosis, Primary Cutaneous

Precursor Proteins:

Primary Name:	Transthyretin
Gene Name:	TTR
Alternative Protein Names:	Transthyretin (ATTR) (Prealbumin) (TBPA)
ISA Nomenclature:	ATTR
Protein Length:	147
Precursor Protein Sequence:	MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
UniProt AC:	P02766
UniProt ID:	TTHY_HUMAN
AmyPro:

Primary Name:	Immunoglobulin kappa light chain
Gene Name:	IGK
Alternative Protein Names:	Immunoglobulin kappa light chain (Immunoglobulin kappa light chain EU)
ISA Nomenclature:	AL
Protein Length:	214
Precursor Protein Sequence:	DIQMTQSPSTLSASVGDRVTITCRASQSINTWLAWYQQKPGKAPKLLMYKASSLESGVPSRFIGSGSGTEFTLTISSLQPDDFATYYCQQYNSDSKMFGQGTKVEVKGTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
UniProt AC:	P0DOX7
UniProt ID:	IGK_HUMAN
AmyPro:

Primary Name:	Immunoglobulin lambda-1 light chain
Gene Name:	IGL1
Alternative Protein Names:	Immunoglobulin lambda-1 light chain (Immunoglobulin lambda-1 light chain MCG)
ISA Nomenclature:	AL
Protein Length:	216
Precursor Protein Sequence:	QSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNFVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
UniProt AC:	P0DOX8
UniProt ID:	IGL1_HUMAN
AmyPro:

Co-deposited Proteins:

No information available

MeSH:
ICD:
OMIM:
PubMed:

Protein Information

Protein Information

Protein Information