AmyCo

Basic Information

Disease Name:

Lupus Erythematosus, Systemic

Alternative Names:

Libman-Sacks Disease
Lupus Erythematosus Disseminatus
Systemic Lupus Erythematosus
SLE

MeSH Description:

A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Type:

Clinical condition associated with amyloidosis

ICD-10 Classification

Diseases of the Musculoskeletal System and Connective Tissue

Tissue:

Kidney, Heart, Lung, Bone Marrow, Gastrointestinal Tract, Liver, Spleen, Adrenal Cortex

Associated Amyloidosis:

AA Amyloidosis

Precursor Proteins:

Primary Name:	Serum amyloid A-1 protein
Gene Name:	SAA1
Alternative Protein Names:	Serum amyloid A-1 protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(2-103); Serum amyloid protein A(2-102); Serum amyloid protein A(4-101)]
ISA Nomenclature:	AA
Protein Length:	122
Precursor Protein Sequence:	MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt AC:	P0DJI8
UniProt ID:	SAA1_HUMAN
AmyPro:	AP00005

Primary Name:	Serum amyloid A-2 protein
Gene Name:	SAA2
Alternative Protein Names:	Serum amyloid A-2 protein (SAA2)
ISA Nomenclature:	AA
Protein Length:	122
Precursor Protein Sequence:	MKLLTGLVFCSLVLSVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVISNARENIQRLTGRGAEDSLADQAANKWGRSGRDPNHFRPAGLPEKY
UniProt AC:	P0DJI9
UniProt ID:	SAA2_HUMAN
AmyPro:

Co-deposited Proteins:

No information available

MeSH:
ICD:
OMIM:
PubMed:

Protein Information

Protein Information