Dementia with Lobar Atrophy and Neuronal Cytoplasmic Inclusions
Lobar Atrophy (Brain)
Lobar Atrophy Of Brain
Lobar Atrophy of the Brain
Pick Disease
Pick Disease Of Brain
Pick's Disease
Picks Disease of Brain
MeSH Description:
A rare form of dementia that is sometimes familial. Clinical features include aphasia; apraxia; confusion; anomia; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the frontal lobe and temporal lobe. Neuronal loss is maximal in the hippocampus, entorhinal cortex, and amygdala. Some ballooned cortical neurons contain argentophylic (Pick) bodies.
Type:
Amyloidosis
ICD-10 Classification
Diseases of the Nervous System
Tissue:
Central Nervous System (CNS)
Precursor Proteins:
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Protein Information
Primary Name:
Tau
Gene Name:
MAPT
Alternative Protein Names:
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
