ID: 1

Disease Name: Alzheimer Disease

Description: A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxias and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques; neurofibrillary tangles; and neuropil threads.

Disease Type: Amyloidosis

ICD-10 Classification: Diseases of the Nervous System

Tissue: Central Nervous System (CNS)

Cross References
http://apps.who.int/classifications/icd10/browse/2016/en#/G30

https://meshb.nlm.nih.gov/record/ui?ui=D000544

https://www.omim.org/entry/104300

https://www.ncbi.nlm.nih.gov/pubmed/8713166

https://www.ncbi.nlm.nih.gov/pubmed/6375662

https://www.ncbi.nlm.nih.gov/pubmed/3159021

https://www.ncbi.nlm.nih.gov/pubmed/17065112

Alternative Names:
Acute Confusional Senile Dementia
Alzheimer Dementia
Alzheimer Disease, Early Onset
Alzheimer Disease, Late Onset
Alzheimer Sclerosis
Alzheimer Syndrome
Alzheimer Type Senile Dementia
Alzheimer's Disease
Alzheimer's Disease, Focal Onset
Alzheimer-Type Dementia (ATD)
Dementia, Alzheimer Type
Dementia, Presenile
Dementia, Primary Senile Degenerative
Dementia, Senile
Early Onset Alzheimer Disease
Familial Alzheimer Disease (FAD)
Focal Onset Alzheimer's Disease
Late Onset Alzheimer Disease
Presenile Alzheimer Dementia
Primary Senile Degenerative Dementia
Senile Dementia, Acute Confusional
Senile Dementia, Alzheimer Type 
Presenile and Senile Dementia

Precursor Proteins:
P05067 | Amyloid-beta A4 protein


Co-deposited Proteins:
P01011 | Alpha-1-antichymotrypsin
P01034 | Cystatin-C
P02649 | Apolipoprotein E
P02743 | Serum amyloid P-component
P07339 | Cathepsin D
P07858 | Cathepsin B
P10909 | Clusterin
P98160 | Basement membrane-specific heparan sulfate proteoglycan core protein
P10636 | Tau
P01023 | Alpha-2-macroglobulin
P05231 | Interleukin-6


Link to Amyloidosis: 
	No information available
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