ID: 14

Disease Name: Amyotrophic Lateral Sclerosis 1

Description: A degenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, fasciculation, hyperreflexia, dysarthria, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous astrocytes and atrophy of anterior spinal nerve roots and corticospinal tracts.

Disease Type: Amyloidosis

ICD-10 Classification: Diseases of the Nervous System

Tissue: Central Nervous System (CNS)

Cross References
http://apps.who.int/classifications/icd10/browse/2016/en#/G12

https://meshb.nlm.nih.gov/record/ui?ui=D000690

https://www.omim.org/entry/105400

https://www.ncbi.nlm.nih.gov/pubmed/19022905

https://www.ncbi.nlm.nih.gov/pubmed/19271992

Alternative Names:
ALS (Amyotrophic Lateral Sclerosis)
Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis, Guam Form
Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1
Charcot Disease
Dementia With Amyotrophic Lateral Sclerosis
Gehrig's Disease
Guam Disease
Guam Form of Amyotrophic Lateral Sclerosis
Lou Gehrig Disease
Lou Gehrig's Disease
Lou-Gehrigs Disease
Motor Neuron Disease, Amyotrophic Lateral Sclerosis 
Amyotrophic lateral sclerosis 1, Familial
FALS
Amyotrophic lateral sclerosis 1, Autosomal dominant

Precursor Proteins:
P00441 | Superoxide dismutase [Cu-Zn]


Co-deposited Proteins:
No information available



Link to Amyloidosis: 
	No information available
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