ID: 3

Disease Name: Huntington Disease

Description: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive chorea and dementia in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; depression; hallucinations; and delusions. Eventually intellectual impairment; loss of fine motor control; athetosis; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including seizures; ataxia; dementia; and chorea.

Disease Type: Amyloidosis

ICD-10 Classification: Diseases of the Nervous System

Tissue: Central Nervous System (CNS)

Cross References
http://apps.who.int/classifications/icd10/browse/2016/en#/G10

https://meshb.nlm.nih.gov/record/ui?ui=D006816

https://www.omim.org/entry/143100

https://www.ncbi.nlm.nih.gov/pubmed/9267034

https://www.ncbi.nlm.nih.gov/pubmed/10410676

https://www.ncbi.nlm.nih.gov/pubmed/21163446

Alternative Names:
Akinetic-Rigid Variant of Huntington Disease
Chorea, Chronic Progressive Hereditary (Huntington)
Chronic Progressive Hereditary Chorea (Huntington)
Huntington Chorea
Huntington Chronic Progressive Hereditary Chorea
Huntington Disease, Akinetic-Rigid Variant
Huntington Disease, Juvenile
Huntington Disease, Juvenile-Onset
Huntington Disease, Late Onset
Huntington's Chorea
Huntington's Disease
Juvenile Huntington Disease
Juvenile-Onset Huntington Disease
Late-Onset Huntington Disease
Progressive Chorea, Chronic Hereditary (Huntington)
Progressive Chorea, Hereditary, Chronic (Huntington) 

Precursor Proteins:
P42858 | Huntingtin


Co-deposited Proteins:
No information available



Link to Amyloidosis: 
	No information available
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