ID: 4

Disease Name: Parkinson Disease

Description: A progressive, degenerative neurologic disease characterized by a tremor that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. Lewy bodies are present in the substantia nigra and locus coeruleus but may also be found in a related condition (lewy body disease, diffuse) characterized by dementia in combination with varying degrees of parkinsonism.

Disease Type: Amyloidosis

ICD-10 Classification: Diseases of the Nervous System

Tissue: Central Nervous System (CNS)

Cross References
http://apps.who.int/classifications/icd10/browse/2016/en#/G20

https://meshb.nlm.nih.gov/record/ui?ui=D010300

https://www.omim.org/entry/168600

https://www.ncbi.nlm.nih.gov/pubmed/2357270

https://www.ncbi.nlm.nih.gov/pubmed/10704204

https://www.ncbi.nlm.nih.gov/pubmed/9600990

https://www.ncbi.nlm.nih.gov/pubmed/29191831

Alternative Names:
Idiopathic Parkinson Disease
Idiopathic Parkinson's Disease
Lewy Body Parkinson Disease
Lewy Body Parkinson's Disease
Paralysis Agitans
Parkinson Disease, Idiopathic
Parkinson's Disease
Parkinson's Disease, Idiopathic
Parkinson's Disease, Lewy Body
Primary Parkinsonism 
Parkinson Disease, Late-Onset

Precursor Proteins:
P37840 | Alpha-synuclein


Co-deposited Proteins:
O00468 | Agrin
P27348 | 14-3-3 protein theta
P46821 | Microtubule-associated protein 1B
P61981 | 14-3-3 protein gamma
P62258 | 14-3-3 protein epsilon
P63104 | 14-3-3 protein zeta/delta
Q9Y6H5 | Synphilin-1


Link to Amyloidosis: 
	No information available
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