ID: 8

Disease Name: Immunoglobulin Light-chain Amyloidosis

Description: A nonproliferative disorder of the plasma cell characterized by excessive production and misfolding of immunoglobulin light chains that form insoluble amyloid fibrils (see amyloid deposits) in various tissues. Clinical features include liver failure; multiple myeloma; nephrotic syndrome; restrictive cardiomyopathy, and neuropathies.

Disease Type: Amyloidosis

ISA Name: AL Amyloidosis

ICD-10 Classification: Amyloidosis

Tissue: Kidney, Heart, Peripheral Nervous System (PNS), Autonomic Nervous System (ANS), Liver, Gastrointestinal Tract, Lung, Soft Tissues, Urinary Tract, Larynx

Cross References
http://apps.who.int/classifications/icd10/browse/2016/en#/E85

https://meshb.nlm.nih.gov/record/ui?ui=D000075363

https://www.ncbi.nlm.nih.gov/pubmed/4102463

https://www.ncbi.nlm.nih.gov/pubmed/22335280

https://www.ncbi.nlm.nih.gov/pubmed/1565488

https://www.ncbi.nlm.nih.gov/pubmed/5011672

https://www.ncbi.nlm.nih.gov/pubmed/2813458

https://www.ncbi.nlm.nih.gov/pubmed/24082415

https://www.ncbi.nlm.nih.gov/pubmed/11126834

Alternative Names:
Amyloidosis, Immunoglobulin Light-chain
Amyloidosis, Primary
Primary Amyloidosis
Primary Systemic Amyloidosis
Light-chain amyloidosis
Light Chain Associated Amyloidosis
Immunoglobulin light chain (AL) amyloidosis
Light chain (AL) amyloidosis

Precursor Proteins:
P0DOX7 | Immunoglobulin kappa light chain
P0DOX8 | Immunoglobulin lambda-1 light chain


Co-deposited Proteins:
P02649 | Apolipoprotein E
P02743 | Serum amyloid P-component
P02751 | Fibronectin
P25391 | Laminin subunit alpha-1
P98160 | Basement membrane-specific heparan sulfate proteoglycan core protein


Link to Amyloidosis: 
	No information available
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