PerMemDB
A database for eukaryotic peripheral membrane proteins
PerMemDB
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R-CFA-8856828: Clathrin-mediated endocytosis
R-GGA-109704: PI3K Cascade
R-GGA-112399: IRS-mediated signalling
R-GGA-112412: SOS-mediated signalling
R-GGA-1257604: PIP3 activates AKT signaling
R-GGA-1266695: Interleukin-7 signaling
R-GGA-198203: PI3K/AKT activation
R-GGA-2428928: IRS-related events triggered by IGF1R
R-GGA-5673001: RAF/MAP kinase cascade
R-GGA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-GGA-74713: IRS activation
R-GGA-74749: Signal attenuation
R-GGA-8853659: RET signaling
R-CFA-114508: Effects of PIP2 hydrolysis
R-CEL-432722: Golgi Associated Vesicle Biogenesis
R-CEL-8856828: Clathrin-mediated endocytosis
R-MMU-1660661: Sphingolipid de novo biosynthesis
R-DRE-193648: NRAGE signals death through JNK
R-DRE-194840: Rho GTPase cycle
R-XTR-193648: NRAGE signals death through JNK
R-XTR-194840: Rho GTPase cycle
R-DRE-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-MMU-193648: NRAGE signals death through JNK
R-MMU-194840: Rho GTPase cycle
R-CEL-114508: Effects of PIP2 hydrolysis
R-SSC-354192: Integrin alphaIIb beta3 signaling
R-SSC-392517: Rap1 signalling
R-GGA-1169092: Activation of RAS in B cells
R-XTR-3928662: EPHB-mediated forward signaling
R-XTR-8856825: Cargo recognition for clathrin-mediated endocytosis
R-XTR-8856828: Clathrin-mediated endocytosis
R-DRE-114508: Effects of PIP2 hydrolysis
R-CFA-194840: Rho GTPase cycle
R-MMU-114608: Platelet degranulation
R-XTR-432722: Golgi Associated Vesicle Biogenesis
R-GGA-1660514: Synthesis of PIPs at the Golgi membrane
R-GGA-1660516: Synthesis of PIPs at the early endosome membrane
R-GGA-1660517: Synthesis of PIPs at the late endosome membrane
R-GGA-193648: NRAGE signals death through JNK
R-GGA-194840: Rho GTPase cycle
R-GGA-416482: G alpha (12/13) signalling events
R-GGA-416572: Sema4D induced cell migration and growth-cone collapse
R-BTA-140834: Extrinsic Pathway of Fibrin Clot Formation
R-BTA-140837: Intrinsic Pathway of Fibrin Clot Formation
R-BTA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-CFA-1660516: Synthesis of PIPs at the early endosome membrane
R-CFA-1660517: Synthesis of PIPs at the late endosome membrane
R-CFA-2173788: Downregulation of TGF-beta receptor signaling
R-RNO-399719: Trafficking of AMPA receptors
R-RNO-6794361: Neurexins and neuroligins
R-SSC-2029482: Regulation of actin dynamics for phagocytic cup formation
R-SSC-2424491: DAP12 signaling
R-SSC-2871809: FCERI mediated Ca+2 mobilization
R-SSC-416476: G alpha (q) signalling events
R-SSC-416482: G alpha (12/13) signalling events
R-SSC-5663213: RHO GTPases Activate WASPs and WAVEs
R-SSC-8964315: G beta:gamma signalling through BTK
R-SSC-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-MMU-6794361: Neurexins and neuroligins
R-SSC-5658442: Regulation of RAS by GAPs
R-SSC-199418: Negative regulation of the PI3K/AKT network
R-CFA-4641258: Degradation of DVL
R-SSC-8876198: RAB GEFs exchange GTP for GDP on RABs
R-SSC-1660499: Synthesis of PIPs at the plasma membrane
R-GGA-1433557: Signaling by SCF-KIT
R-GGA-74751: Insulin receptor signalling cascade
R-BTA-114608: Platelet degranulation
R-BTA-140875: Common Pathway of Fibrin Clot Formation
R-BTA-204005: COPII-mediated vesicle transport
R-BTA-5694530: Cargo concentration in the ER
R-GGA-192105: Synthesis of bile acids and bile salts
R-SSC-1482788: Acyl chain remodelling of PC
R-SSC-1482801: Acyl chain remodelling of PS
R-SSC-1482839: Acyl chain remodelling of PE
R-SSC-1482925: Acyl chain remodelling of PG
R-SSC-1483115: Hydrolysis of LPC
R-SSC-1483166: Synthesis of PA
R-DRE-416476: G alpha (q) signalling events
R-DRE-418885: DCC mediated attractive signaling
R-BTA-202733: Cell surface interactions at the vascular wall
R-BTA-375276: Peptide ligand-binding receptors
R-BTA-416476: G alpha (q) signalling events
R-BTA-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-BTA-76009: Platelet Aggregation (Plug Formation)
R-BTA-977606: Regulation of Complement cascade
R-MMU-3928663: EPHA-mediated growth cone collapse
R-RNO-6798695: Neutrophil degranulation
R-RNO-9020702: Interleukin-1 signaling
R-DME-2453902: The canonical retinoid cycle in rods (twilight vision)
R-SSC-166016: Toll Like Receptor 4 (TLR4) Cascade
R-SSC-190873: Gap junction degradation
R-SSC-196025: Formation of annular gap junctions
R-SSC-2132295: MHC class II antigen presentation
R-SSC-437239: Recycling pathway of L1
R-SSC-8856828: Clathrin-mediated endocytosis
R-HSA-1445148: Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-RNO-194840: Rho GTPase cycle
R-XTR-6798695: Neutrophil degranulation
R-RNO-112043: PLC beta mediated events
R-RNO-1855204: Synthesis of IP3 and IP4 in the cytosol
R-RNO-416476: G alpha (q) signalling events
R-BTA-112412: SOS-mediated signalling
R-BTA-1250347: SHC1 events in ERBB4 signaling
R-BTA-1433557: Signaling by SCF-KIT
R-BTA-1433559: Regulation of KIT signaling
R-BTA-167044: Signalling to RAS
R-BTA-179812: GRB2 events in EGFR signaling
R-BTA-180336: SHC1 events in EGFR signaling
R-BTA-186763: Downstream signal transduction
R-BTA-193648: NRAGE signals death through JNK
R-BTA-194840: Rho GTPase cycle
R-BTA-1963640: GRB2 events in ERBB2 signaling
R-BTA-210993: Tie2 Signaling
R-BTA-2179392: EGFR Transactivation by Gastrin
R-BTA-2424491: DAP12 signaling
R-BTA-2428933: SHC-related events triggered by IGF1R
R-BTA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-BTA-2871796: FCERI mediated MAPK activation
R-BTA-2871809: FCERI mediated Ca+2 mobilization
R-BTA-375165: NCAM signaling for neurite out-growth
R-BTA-5654688: SHC-mediated cascade:FGFR1
R-BTA-5654693: FRS-mediated FGFR1 signaling
R-BTA-5654699: SHC-mediated cascade:FGFR2
R-BTA-5654700: FRS-mediated FGFR2 signaling
R-BTA-5654704: SHC-mediated cascade:FGFR3
R-BTA-5654706: FRS-mediated FGFR3 signaling
R-BTA-5654712: FRS-mediated FGFR4 signaling
R-BTA-5654719: SHC-mediated cascade:FGFR4
R-BTA-5673001: RAF/MAP kinase cascade
R-BTA-74749: Signal attenuation
R-BTA-74751: Insulin receptor signalling cascade
R-BTA-8853659: RET signaling
R-BTA-8983432: Interleukin-15 signaling
R-BTA-9028731: Activated NTRK2 signals through FRS2 and FRS3
R-BTA-912526: Interleukin receptor SHC signaling
R-BTA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-CFA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-CFA-2424491: DAP12 signaling
R-CFA-2871809: FCERI mediated Ca+2 mobilization
R-CFA-416476: G alpha (q) signalling events
R-CFA-416482: G alpha (12/13) signalling events
R-CFA-5663213: RHO GTPases Activate WASPs and WAVEs
R-CFA-8964315: G beta:gamma signalling through BTK
R-CFA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-SSC-1660661: Sphingolipid de novo biosynthesis
R-CFA-2672351: Stimuli-sensing channels
R-CFA-392517: Rap1 signalling
R-CFA-430116: GP1b-IX-V activation signalling
R-CFA-5621575: CD209 (DC-SIGN) signaling
R-CFA-5673000: RAF activation
R-CFA-5674135: MAP2K and MAPK activation
R-CFA-5674499: Negative feedback regulation of MAPK pathway
R-CFA-5675221: Negative regulation of MAPK pathway
R-BTA-111465: Apoptotic cleavage of cellular proteins
R-BTA-111933: Calmodulin induced events
R-BTA-114508: Effects of PIP2 hydrolysis
R-BTA-1250196: SHC1 events in ERBB2 signaling
R-BTA-1489509: DAG and IP3 signaling
R-BTA-2029485: Role of phospholipids in phagocytosis
R-BTA-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-BTA-5218921: VEGFR2 mediated cell proliferation
R-BTA-5607764: CLEC7A (Dectin-1) signaling
R-BTA-6798695: Neutrophil degranulation
R-BTA-877300: Interferon gamma signaling
R-SSC-4420097: VEGFA-VEGFR2 Pathway
R-SSC-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-CFA-114608: Platelet degranulation
R-XTR-114608: Platelet degranulation
R-DME-1660499: Synthesis of PIPs at the plasma membrane
R-DME-1660517: Synthesis of PIPs at the late endosome membrane
R-GGA-1442490: Collagen degradation
R-GGA-1474244: Extracellular matrix organization
R-GGA-1650814: Collagen biosynthesis and modifying enzymes
R-GGA-186797: Signaling by PDGF
R-GGA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-GGA-2022090: Assembly of collagen fibrils and other multimeric structures
R-GGA-216083: Integrin cell surface interactions
R-GGA-3000171: Non-integrin membrane-ECM interactions
R-GGA-3000178: ECM proteoglycans
R-GGA-8874081: MET activates PTK2 signaling
R-GGA-8948216: Collagen chain trimerization
R-HSA-1912408: Pre-NOTCH Transcription and Translation
R-HSA-209543: p75NTR recruits signalling complexes
R-HSA-420029: Tight junction interactions
R-GGA-1253288: Downregulation of ERBB4 signaling
R-GGA-8948747: Regulation of PTEN localization
R-GGA-8948751: Regulation of PTEN stability and activity
R-GGA-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-MMU-114604: GPVI-mediated activation cascade
R-MMU-2029482: Regulation of actin dynamics for phagocytic cup formation
R-MMU-2424491: DAP12 signaling
R-MMU-2871796: FCERI mediated MAPK activation
R-MMU-2871809: FCERI mediated Ca+2 mobilization
R-MMU-3928665: EPH-ephrin mediated repulsion of cells
R-MMU-4420097: VEGFA-VEGFR2 Pathway
R-MMU-5218920: VEGFR2 mediated vascular permeability
R-SSC-193648: NRAGE signals death through JNK
R-SSC-194840: Rho GTPase cycle
R-SSC-3928662: EPHB-mediated forward signaling
R-SSC-3928665: EPH-ephrin mediated repulsion of cells
R-CFA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-1482801: Acyl chain remodelling of PS
R-GGA-8856828: Clathrin-mediated endocytosis
R-DRE-5658442: Regulation of RAS by GAPs
R-GGA-5625900: RHO GTPases activate CIT
R-CFA-5620924: Intraflagellar transport
R-CFA-1433559: Regulation of KIT signaling
R-CFA-983231: Factors involved in megakaryocyte development and platelet production
R-XTR-1912408: Pre-NOTCH Transcription and Translation
R-XTR-209543: p75NTR recruits signalling complexes
R-XTR-420029: Tight junction interactions
R-GGA-5620912: Anchoring of the basal body to the plasma membrane
R-GGA-4641258: Degradation of DVL
R-CFA-6811438: Intra-Golgi traffic
R-RNO-1483166: Synthesis of PA
R-RNO-2029485: Role of phospholipids in phagocytosis
R-CEL-182971: EGFR downregulation
R-CEL-432720: Lysosome Vesicle Biogenesis
R-CEL-6807004: Negative regulation of MET activity
R-CEL-8856825: Cargo recognition for clathrin-mediated endocytosis
R-CEL-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-SSC-114608: Platelet degranulation
R-SSC-140875: Common Pathway of Fibrin Clot Formation
R-SSC-159740: Gamma-carboxylation of protein precursors
R-SSC-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-SSC-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-SSC-202733: Cell surface interactions at the vascular wall
R-SSC-977606: Regulation of Complement cascade
R-GGA-416476: G alpha (q) signalling events
R-GGA-418594: G alpha (i) signalling events
R-GGA-444473: Formyl peptide receptors bind formyl peptides and many other ligands
R-SSC-399719: Trafficking of AMPA receptors
R-SSC-6794361: Neurexins and neuroligins
R-XTR-112043: PLC beta mediated events
R-XTR-1855204: Synthesis of IP3 and IP4 in the cytosol
R-XTR-416476: G alpha (q) signalling events
R-RNO-114508: Effects of PIP2 hydrolysis
R-RNO-114608: Platelet degranulation
R-RNO-140875: Common Pathway of Fibrin Clot Formation
R-RNO-159740: Gamma-carboxylation of protein precursors
R-RNO-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-RNO-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-RNO-202733: Cell surface interactions at the vascular wall
R-MMU-8856825: Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828: Clathrin-mediated endocytosis
R-DRE-8856828: Clathrin-mediated endocytosis
R-BTA-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-SSC-114508: Effects of PIP2 hydrolysis
R-RNO-8856825: Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828: Clathrin-mediated endocytosis
R-CFA-193648: NRAGE signals death through JNK
R-HSA-114508: Effects of PIP2 hydrolysis
R-RNO-182971: EGFR downregulation
R-RNO-193648: NRAGE signals death through JNK
R-RNO-3928664: Ephrin signaling
R-SSC-181429: Serotonin Neurotransmitter Release Cycle
R-SSC-181430: Norepinephrine Neurotransmitter Release Cycle
R-SSC-210500: Glutamate Neurotransmitter Release Cycle
R-SSC-212676: Dopamine Neurotransmitter Release Cycle
R-SSC-264642: Acetylcholine Neurotransmitter Release Cycle
R-SSC-888590: GABA synthesis, release, reuptake and degradation
R-BTA-1169092: Activation of RAS in B cells
R-BTA-354192: Integrin alphaIIb beta3 signaling
R-BTA-392517: Rap1 signalling
R-XTR-140875: Common Pathway of Fibrin Clot Formation
R-XTR-159740: Gamma-carboxylation of protein precursors
R-XTR-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-XTR-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-XTR-202733: Cell surface interactions at the vascular wall
R-HSA-1660499: Synthesis of PIPs at the plasma membrane
R-HSA-1660514: Synthesis of PIPs at the Golgi membrane
R-HSA-1660516: Synthesis of PIPs at the early endosome membrane
R-HSA-1660517: Synthesis of PIPs at the late endosome membrane
R-HSA-432722: Golgi Associated Vesicle Biogenesis
R-HSA-8856828: Clathrin-mediated endocytosis
R-DRE-1855204: Synthesis of IP3 and IP4 in the cytosol
R-CFA-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-CEL-1169092: Activation of RAS in B cells
R-CEL-354192: Integrin alphaIIb beta3 signaling
R-CEL-392517: Rap1 signalling
R-CEL-5673001: RAF/MAP kinase cascade
R-HSA-6794361: Neurexins and neuroligins
R-DME-2029482: Regulation of actin dynamics for phagocytic cup formation
R-DME-4420097: VEGFA-VEGFR2 Pathway
R-DME-5663213: RHO GTPases Activate WASPs and WAVEs
R-CEL-114604: GPVI-mediated activation cascade
R-CEL-1433557: Signaling by SCF-KIT
R-CEL-193648: NRAGE signals death through JNK
R-CEL-194840: Rho GTPase cycle
R-CEL-2871796: FCERI mediated MAPK activation
R-CEL-3928665: EPH-ephrin mediated repulsion of cells
R-CEL-4420097: VEGFA-VEGFR2 Pathway
R-CEL-5218920: VEGFR2 mediated vascular permeability
R-CEL-912631: Regulation of signaling by CBL
R-BTA-1257604: PIP3 activates AKT signaling
R-BTA-165158: Activation of AKT2
R-BTA-165181: Inhibition of TSC complex formation by PKB
R-BTA-199418: Negative regulation of the PI3K/AKT network
R-BTA-3769402: Deactivation of the beta-catenin transactivating complex
R-BTA-389357: CD28 dependent PI3K/Akt signaling
R-BTA-389513: CTLA4 inhibitory signaling
R-BTA-392451: G beta:gamma signalling through PI3Kgamma
R-BTA-5218920: VEGFR2 mediated vascular permeability
R-BTA-6804757: Regulation of TP53 Degradation
R-BTA-6804758: Regulation of TP53 Activity through Acetylation
R-SSC-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-SSC-5218921: VEGFR2 mediated cell proliferation
R-GGA-354192: Integrin alphaIIb beta3 signaling
R-GGA-392517: Rap1 signalling
R-BTA-6794361: Neurexins and neuroligins
R-DRE-432722: Golgi Associated Vesicle Biogenesis
R-DRE-1660499: Synthesis of PIPs at the plasma membrane
R-MMU-114508: Effects of PIP2 hydrolysis
R-MMU-1483166: Synthesis of PA
R-MMU-2029485: Role of phospholipids in phagocytosis
R-MMU-6798695: Neutrophil degranulation
R-DRE-192105: Synthesis of bile acids and bile salts
R-SSC-1483248: Synthesis of PIPs at the ER membrane
R-SSC-1660516: Synthesis of PIPs at the early endosome membrane
R-SSC-1660517: Synthesis of PIPs at the late endosome membrane
R-SSC-111933: Calmodulin induced events
R-SSC-418555: G alpha (s) signalling events
R-SSC-5635838: Activation of SMO
R-SSC-8856825: Cargo recognition for clathrin-mediated endocytosis
R-CFA-5658442: Regulation of RAS by GAPs
R-DRE-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-DRE-983189: Kinesins
R-CFA-432722: Golgi Associated Vesicle Biogenesis
R-CFA-2132295: MHC class II antigen presentation
R-CFA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-CFA-983189: Kinesins
R-SSC-6798695: Neutrophil degranulation
R-DRE-437239: Recycling pathway of L1
R-DRE-5610780: Degradation of GLI1 by the proteasome
R-DRE-5632684: Hedgehog 'on' state
R-SSC-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-BTA-432722: Golgi Associated Vesicle Biogenesis
R-BTA-8856828: Clathrin-mediated endocytosis
R-CFA-1482801: Acyl chain remodelling of PS
R-DRE-182971: EGFR downregulation
R-DRE-6807004: Negative regulation of MET activity
R-DRE-8856825: Cargo recognition for clathrin-mediated endocytosis
R-CEL-192105: Synthesis of bile acids and bile salts
R-XTR-2029482: Regulation of actin dynamics for phagocytic cup formation
R-XTR-4420097: VEGFA-VEGFR2 Pathway
R-XTR-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-DRE-392517: Rap1 signalling
R-DRE-430116: GP1b-IX-V activation signalling
R-DRE-5621575: CD209 (DC-SIGN) signaling
R-DRE-5673000: RAF activation
R-DRE-5674135: MAP2K and MAPK activation
R-DRE-5674499: Negative feedback regulation of MAPK pathway
R-DRE-5675221: Negative regulation of MAPK pathway
R-HSA-6798695: Neutrophil degranulation
R-HSA-9020702: Interleukin-1 signaling
R-DRE-140834: Extrinsic Pathway of Fibrin Clot Formation
R-DRE-159740: Gamma-carboxylation of protein precursors
R-DRE-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-SSC-8941237: Invadopodia formation
R-GGA-1483166: Synthesis of PA
R-GGA-6798695: Neutrophil degranulation
R-SSC-192105: Synthesis of bile acids and bile salts
R-SSC-1855204: Synthesis of IP3 and IP4 in the cytosol
R-BTA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-BTA-3928662: EPHB-mediated forward signaling
R-BTA-418885: DCC mediated attractive signaling
R-BTA-4420097: VEGFA-VEGFR2 Pathway
R-BTA-5663213: RHO GTPases Activate WASPs and WAVEs
R-SSC-1169092: Activation of RAS in B cells
R-SSC-5673001: RAF/MAP kinase cascade
R-XTR-114604: GPVI-mediated activation cascade
R-XTR-2424491: DAP12 signaling
R-XTR-2871796: FCERI mediated MAPK activation
R-XTR-2871809: FCERI mediated Ca+2 mobilization
R-XTR-3928665: EPH-ephrin mediated repulsion of cells
R-XTR-5218920: VEGFR2 mediated vascular permeability
R-BTA-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-XTR-114508: Effects of PIP2 hydrolysis
R-GGA-182971: EGFR downregulation
R-CFA-202433: Generation of second messenger molecules
R-GGA-114608: Platelet degranulation
R-GGA-140837: Intrinsic Pathway of Fibrin Clot Formation
R-GGA-140875: Common Pathway of Fibrin Clot Formation
R-GGA-204005: COPII-mediated vesicle transport
R-GGA-5694530: Cargo concentration in the ER
R-SSC-2173789: TGF-beta receptor signaling activates SMADs
R-MMU-391160: Signal regulatory protein family interactions
R-SSC-432722: Golgi Associated Vesicle Biogenesis
R-GGA-114508: Effects of PIP2 hydrolysis
R-XTR-111465: Apoptotic cleavage of cellular proteins
R-XTR-1250196: SHC1 events in ERBB2 signaling
R-XTR-1489509: DAG and IP3 signaling
R-XTR-2029485: Role of phospholipids in phagocytosis
R-XTR-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-XTR-5218921: VEGFR2 mediated cell proliferation
R-XTR-5607764: CLEC7A (Dectin-1) signaling
R-XTR-877300: Interferon gamma signaling
R-DME-432722: Golgi Associated Vesicle Biogenesis
R-BTA-182971: EGFR downregulation
R-BTA-3928664: Ephrin signaling
R-XTR-1169092: Activation of RAS in B cells
R-XTR-354192: Integrin alphaIIb beta3 signaling
R-XTR-392517: Rap1 signalling
R-XTR-5673001: RAF/MAP kinase cascade
R-CFA-3928662: EPHB-mediated forward signaling
R-CEL-6798695: Neutrophil degranulation
R-CFA-8866427: VLDLR internalisation and degradation
R-CFA-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-XTR-192105: Synthesis of bile acids and bile salts
R-HSA-194840: Rho GTPase cycle
R-MMU-5610787: Hedgehog 'off' state
R-MMU-399719: Trafficking of AMPA receptors
R-BTA-109704: PI3K Cascade
R-GGA-1482788: Acyl chain remodelling of PC
R-GGA-1482801: Acyl chain remodelling of PS
R-GGA-1482839: Acyl chain remodelling of PE
R-GGA-1482922: Acyl chain remodelling of PI
R-GGA-1482925: Acyl chain remodelling of PG
R-GGA-1483115: Hydrolysis of LPC
R-CFA-1660661: Sphingolipid de novo biosynthesis
R-CFA-182971: EGFR downregulation
R-CFA-6807004: Negative regulation of MET activity
R-DRE-199418: Negative regulation of the PI3K/AKT network
R-DRE-202424: Downstream TCR signaling
R-DRE-5689880: Ub-specific processing proteases
R-DRE-5689896: Ovarian tumor domain proteases
R-DRE-8948751: Regulation of PTEN stability and activity
R-RNO-5658442: Regulation of RAS by GAPs
R-HSA-193648: NRAGE signals death through JNK
R-HSA-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-416482: G alpha (12/13) signalling events
R-SSC-1250196: SHC1 events in ERBB2 signaling
R-SSC-1489509: DAG and IP3 signaling
R-SSC-2029485: Role of phospholipids in phagocytosis
R-SSC-1483206: Glycerophospholipid biosynthesis
R-MMU-1474228: Degradation of the extracellular matrix
R-DRE-168138: Toll Like Receptor 9 (TLR9) Cascade
R-DRE-983231: Factors involved in megakaryocyte development and platelet production
R-RNO-5620916: VxPx cargo-targeting to cilium
R-CFA-111465: Apoptotic cleavage of cellular proteins
R-CFA-354192: Integrin alphaIIb beta3 signaling
R-CFA-354194: GRB2:SOS provides linkage to MAPK signaling for Integrins
R-CFA-372708: p130Cas linkage to MAPK signaling for integrins
R-CFA-375165: NCAM signaling for neurite out-growth
R-CFA-418885: DCC mediated attractive signaling
R-CFA-4420097: VEGFA-VEGFR2 Pathway
R-CFA-5673001: RAF/MAP kinase cascade
R-CFA-8874081: MET activates PTK2 signaling
R-RNO-437239: Recycling pathway of L1
R-SPO-5625740: RHO GTPases activate PKNs
R-GGA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-GGA-4420097: VEGFA-VEGFR2 Pathway
R-GGA-5663213: RHO GTPases Activate WASPs and WAVEs
R-DME-1855204: Synthesis of IP3 and IP4 in the cytosol
R-DME-199418: Negative regulation of the PI3K/AKT network
R-DME-202424: Downstream TCR signaling
R-DME-5689880: Ub-specific processing proteases
R-DME-8948747: Regulation of PTEN localization
R-DME-8948751: Regulation of PTEN stability and activity
R-RNO-8875513: MET interacts with TNS proteins
R-MMU-192105: Synthesis of bile acids and bile salts
R-XTR-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-XTR-983189: Kinesins
R-GGA-446353: Cell-extracellular matrix interactions
R-DME-8856828: Clathrin-mediated endocytosis
R-XTR-2132295: MHC class II antigen presentation
R-CFA-5626978: TNFR1-mediated ceramide production
R-DRE-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-CFA-8983432: Interleukin-15 signaling
R-SSC-75205: Dissolution of Fibrin Clot
R-RNO-3000171: Non-integrin membrane-ECM interactions
R-RNO-983231: Factors involved in megakaryocyte development and platelet production
R-DRE-5620912: Anchoring of the basal body to the plasma membrane
R-GGA-1483248: Synthesis of PIPs at the ER membrane
R-GGA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-SSC-446353: Cell-extracellular matrix interactions
R-RNO-5173214: O-glycosylation of TSR domain-containing proteins
R-DRE-8854214: TBC/RABGAPs
R-DRE-3928662: EPHB-mediated forward signaling
R-SSC-8854214: TBC/RABGAPs
R-XTR-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-2672351: Stimuli-sensing channels
R-XTR-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-BTA-8951664: Neddylation
R-DRE-114608: Platelet degranulation
R-GGA-391160: Signal regulatory protein family interactions
R-MMU-8948751: Regulation of PTEN stability and activity
R-DME-114508: Effects of PIP2 hydrolysis
R-DME-1250196: SHC1 events in ERBB2 signaling
R-DME-1489509: DAG and IP3 signaling
R-DME-2029485: Role of phospholipids in phagocytosis
R-GGA-2672351: Stimuli-sensing channels
R-GGA-430116: GP1b-IX-V activation signalling
R-GGA-5621575: CD209 (DC-SIGN) signaling
R-GGA-5673000: RAF activation
R-GGA-5674135: MAP2K and MAPK activation
R-GGA-5674499: Negative feedback regulation of MAPK pathway
R-GGA-5675221: Negative regulation of MAPK pathway
R-SSC-5674135: MAP2K and MAPK activation
R-XTR-5626978: TNFR1-mediated ceramide production
R-DRE-1660514: Synthesis of PIPs at the Golgi membrane
R-DRE-1660516: Synthesis of PIPs at the early endosome membrane
R-GGA-1660661: Sphingolipid de novo biosynthesis
R-SSC-1912408: Pre-NOTCH Transcription and Translation
R-SSC-209543: p75NTR recruits signalling complexes
R-SSC-420029: Tight junction interactions
R-SSC-112043: PLC beta mediated events
R-SSC-399997: Acetylcholine regulates insulin secretion
R-SSC-4086398: Ca2+ pathway
R-SSC-418217: G beta:gamma signalling through PLC beta
R-SSC-500657: Presynaptic function of Kainate receptors
R-DME-110478: Insulin signaling pathway
R-DME-110523: TOR signaling pathway
R-XTR-1253288: Downregulation of ERBB4 signaling
R-XTR-8948747: Regulation of PTEN localization
R-XTR-8948751: Regulation of PTEN stability and activity
R-GGA-114604: GPVI-mediated activation cascade
R-GGA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-GGA-1855204: Synthesis of IP3 and IP4 in the cytosol
R-GGA-2029485: Role of phospholipids in phagocytosis
R-GGA-2424491: DAP12 signaling
R-GGA-2871796: FCERI mediated MAPK activation
R-GGA-2871809: FCERI mediated Ca+2 mobilization
R-GGA-5607764: CLEC7A (Dectin-1) signaling
R-GGA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-CEL-1253288: Downregulation of ERBB4 signaling
R-CEL-2672351: Stimuli-sensing channels
R-CEL-5610780: Degradation of GLI1 by the proteasome
R-CEL-5632684: Hedgehog 'on' state
R-CEL-8948751: Regulation of PTEN stability and activity
R-CEL-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-CFA-140837: Intrinsic Pathway of Fibrin Clot Formation
R-CFA-140875: Common Pathway of Fibrin Clot Formation
R-CFA-159740: Gamma-carboxylation of protein precursors
R-CFA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-CFA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-CFA-202733: Cell surface interactions at the vascular wall
R-CFA-375276: Peptide ligand-binding receptors
R-CFA-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-CFA-977606: Regulation of Complement cascade
R-GGA-6794361: Neurexins and neuroligins
R-RNO-5610780: Degradation of GLI1 by the proteasome
R-RNO-5632684: Hedgehog 'on' state
R-BTA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-MMU-416482: G alpha (12/13) signalling events
R-GGA-111933: Calmodulin induced events
R-GGA-418555: G alpha (s) signalling events
R-GGA-5635838: Activation of SMO
R-GGA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-SSC-5687128: MAPK6/MAPK4 signaling
R-XTR-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-XTR-3299685: Detoxification of Reactive Oxygen Species
R-XTR-5668599: RHO GTPases Activate NADPH Oxidases
R-RNO-5673000: RAF activation
R-RNO-5674135: MAP2K and MAPK activation
R-RNO-5675221: Negative regulation of MAPK pathway
R-DRE-5610787: Hedgehog 'off' state
R-CFA-1482788: Acyl chain remodelling of PC
R-CFA-1482839: Acyl chain remodelling of PE
R-CFA-1482925: Acyl chain remodelling of PG
R-CFA-1483115: Hydrolysis of LPC
R-CFA-1483166: Synthesis of PA
R-XTR-140834: Extrinsic Pathway of Fibrin Clot Formation
R-XTR-140837: Intrinsic Pathway of Fibrin Clot Formation
R-SSC-1257604: PIP3 activates AKT signaling
R-SSC-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-SSC-165159: mTOR signalling
R-SSC-198323: AKT phosphorylates targets in the cytosol
R-SSC-198693: AKT phosphorylates targets in the nucleus
R-SSC-203615: eNOS activation
R-SSC-389357: CD28 dependent PI3K/Akt signaling
R-SSC-389513: CTLA4 inhibitory signaling
R-SSC-392451: G beta:gamma signalling through PI3Kgamma
R-SSC-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-SSC-5218920: VEGFR2 mediated vascular permeability
R-SSC-6804757: Regulation of TP53 Degradation
R-SSC-6804758: Regulation of TP53 Activity through Acetylation
R-SSC-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SSC-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-BTA-416572: Sema4D induced cell migration and growth-cone collapse
R-XTR-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-XTR-8957275: Post-translational protein phosphorylation
R-RNO-1483248: Synthesis of PIPs at the ER membrane
R-RNO-8876198: RAB GEFs exchange GTP for GDP on RABs
R-CFA-112043: PLC beta mediated events
R-CFA-1855204: Synthesis of IP3 and IP4 in the cytosol
R-XTR-4641258: Degradation of DVL
R-DME-114608: Platelet degranulation
R-DRE-1250196: SHC1 events in ERBB2 signaling
R-DRE-1489509: DAG and IP3 signaling
R-DRE-2029485: Role of phospholipids in phagocytosis
R-RNO-416482: G alpha (12/13) signalling events
R-MMU-159740: Gamma-carboxylation of protein precursors
R-MMU-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-MMU-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-RNO-5620912: Anchoring of the basal body to the plasma membrane
R-MMU-1257604: PIP3 activates AKT signaling
R-MMU-1433557: Signaling by SCF-KIT
R-MMU-389359: CD28 dependent Vav1 pathway
R-MMU-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-9027284: Erythropoietin activates RAS
R-MMU-912631: Regulation of signaling by CBL
R-MMU-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-5620912: Anchoring of the basal body to the plasma membrane
R-CFA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-CFA-8957275: Post-translational protein phosphorylation
R-DDI-194840: Rho GTPase cycle
R-RNO-1660516: Synthesis of PIPs at the early endosome membrane
R-RNO-1660517: Synthesis of PIPs at the late endosome membrane
R-RNO-2173788: Downregulation of TGF-beta receptor signaling
R-DME-192105: Synthesis of bile acids and bile salts
R-XTR-1306955: GRB7 events in ERBB2 signaling
R-XTR-1433557: Signaling by SCF-KIT
R-XTR-186763: Downstream signal transduction
R-XTR-210993: Tie2 Signaling
R-XTR-8853659: RET signaling
R-CFA-190873: Gap junction degradation
R-CFA-196025: Formation of annular gap junctions
R-CFA-3928665: EPH-ephrin mediated repulsion of cells
R-CFA-437239: Recycling pathway of L1
R-CFA-1660499: Synthesis of PIPs at the plasma membrane
R-XTR-202433: Generation of second messenger molecules
R-CFA-5610780: Degradation of GLI1 by the proteasome
R-CFA-5632684: Hedgehog 'on' state
R-MMU-8875513: MET interacts with TNS proteins
R-BTA-2672351: Stimuli-sensing channels
R-CFA-1483206: Glycerophospholipid biosynthesis
R-DRE-140875: Common Pathway of Fibrin Clot Formation
R-DRE-204005: COPII-mediated vesicle transport
R-DRE-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DRE-5694530: Cargo concentration in the ER
R-DRE-8957275: Post-translational protein phosphorylation
R-DME-8951664: Neddylation
R-CEL-3238698: WNT ligand biogenesis and trafficking
R-SSC-1295596: Spry regulation of FGF signaling
R-SSC-5673000: RAF activation
R-SSC-5674499: Negative feedback regulation of MAPK pathway
R-SSC-5675221: Negative regulation of MAPK pathway
R-RNO-1660499: Synthesis of PIPs at the plasma membrane
R-SSC-416572: Sema4D induced cell migration and growth-cone collapse
R-GGA-1433559: Regulation of KIT signaling
R-GGA-983231: Factors involved in megakaryocyte development and platelet production
R-GGA-5627123: RHO GTPases activate PAKs
R-SPO-194840: Rho GTPase cycle
R-DRE-3928664: Ephrin signaling
R-MMU-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-MMU-165159: mTOR signalling
R-MMU-198323: AKT phosphorylates targets in the cytosol
R-MMU-198693: AKT phosphorylates targets in the nucleus
R-MMU-199418: Negative regulation of the PI3K/AKT network
R-MMU-203615: eNOS activation
R-MMU-354192: Integrin alphaIIb beta3 signaling
R-MMU-3769402: Deactivation of the beta-catenin transactivating complex
R-MMU-389357: CD28 dependent PI3K/Akt signaling
R-MMU-389513: CTLA4 inhibitory signaling
R-MMU-392451: G beta:gamma signalling through PI3Kgamma
R-MMU-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-MMU-6804757: Regulation of TP53 Degradation
R-MMU-6804758: Regulation of TP53 Activity through Acetylation
R-MMU-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-RNO-2132295: MHC class II antigen presentation
R-RNO-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-RNO-983189: Kinesins
R-DRE-1660661: Sphingolipid de novo biosynthesis
R-RNO-6811438: Intra-Golgi traffic
R-SSC-1474228: Degradation of the extracellular matrix
R-CEL-210500: Glutamate Neurotransmitter Release Cycle
R-CEL-264642: Acetylcholine Neurotransmitter Release Cycle
R-SSC-8948751: Regulation of PTEN stability and activity
R-DRE-416482: G alpha (12/13) signalling events
R-DRE-416572: Sema4D induced cell migration and growth-cone collapse
R-DRE-373752: Netrin-1 signaling
R-MMU-181429: Serotonin Neurotransmitter Release Cycle
R-MMU-181430: Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500: Glutamate Neurotransmitter Release Cycle
R-MMU-212676: Dopamine Neurotransmitter Release Cycle
R-MMU-264642: Acetylcholine Neurotransmitter Release Cycle
R-MMU-888590: GABA synthesis, release, reuptake and degradation
R-RNO-2029482: Regulation of actin dynamics for phagocytic cup formation
R-RNO-2424491: DAP12 signaling
R-RNO-2871809: FCERI mediated Ca+2 mobilization
R-RNO-5663213: RHO GTPases Activate WASPs and WAVEs
R-RNO-8964315: G beta:gamma signalling through BTK
R-RNO-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-MMU-5625900: RHO GTPases activate CIT
R-GGA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-GGA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-GGA-202733: Cell surface interactions at the vascular wall
R-GGA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-GGA-8957275: Post-translational protein phosphorylation
R-CEL-1660514: Synthesis of PIPs at the Golgi membrane
R-CEL-1660516: Synthesis of PIPs at the early endosome membrane
R-CEL-1660517: Synthesis of PIPs at the late endosome membrane
R-DRE-111465: Apoptotic cleavage of cellular proteins
R-DRE-2029482: Regulation of actin dynamics for phagocytic cup formation
R-DRE-354192: Integrin alphaIIb beta3 signaling
R-DRE-354194: GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DRE-372708: p130Cas linkage to MAPK signaling for integrins
R-DRE-375165: NCAM signaling for neurite out-growth
R-DRE-4420097: VEGFA-VEGFR2 Pathway
R-DRE-5663213: RHO GTPases Activate WASPs and WAVEs
R-DRE-5673001: RAF/MAP kinase cascade
R-DRE-8874081: MET activates PTK2 signaling
R-CFA-114604: GPVI-mediated activation cascade
R-CFA-2029485: Role of phospholipids in phagocytosis
R-CFA-2871796: FCERI mediated MAPK activation
R-CFA-5607764: CLEC7A (Dectin-1) signaling
R-DRE-1912408: Pre-NOTCH Transcription and Translation
R-DRE-209543: p75NTR recruits signalling complexes
R-CFA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-RNO-1169408: ISG15 antiviral mechanism
R-RNO-1253288: Downregulation of ERBB4 signaling
R-RNO-8948747: Regulation of PTEN localization
R-RNO-8948751: Regulation of PTEN stability and activity
R-RNO-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-XTR-1433559: Regulation of KIT signaling
R-XTR-983231: Factors involved in megakaryocyte development and platelet production
R-BTA-1660499: Synthesis of PIPs at the plasma membrane
R-BTA-1660514: Synthesis of PIPs at the Golgi membrane
R-BTA-1660516: Synthesis of PIPs at the early endosome membrane
R-MMU-1482788: Acyl chain remodelling of PC
R-MMU-1482801: Acyl chain remodelling of PS
R-MMU-1482839: Acyl chain remodelling of PE
R-MMU-1482925: Acyl chain remodelling of PG
R-MMU-1483115: Hydrolysis of LPC
R-GGA-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-CFA-201451: Signaling by BMP
R-XTR-111995: phospho-PLA2 pathway
R-XTR-1482788: Acyl chain remodelling of PC
R-XTR-1482798: Acyl chain remodeling of CL
R-XTR-1482801: Acyl chain remodelling of PS
R-XTR-1482839: Acyl chain remodelling of PE
R-XTR-1482922: Acyl chain remodelling of PI
R-XTR-1483115: Hydrolysis of LPC
R-XTR-1483166: Synthesis of PA
R-XTR-2142753: Arachidonic acid metabolism
R-XTR-418592: ADP signalling through P2Y purinoceptor 1
R-XTR-432142: Platelet sensitization by LDL
R-XTR-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-SSC-201451: Signaling by BMP
R-GGA-1632852: Macroautophagy
R-GGA-5668599: RHO GTPases Activate NADPH Oxidases
R-GGA-201451: Signaling by BMP
R-RNO-416572: Sema4D induced cell migration and growth-cone collapse
R-MMU-5658442: Regulation of RAS by GAPs
R-DRE-2132295: MHC class II antigen presentation
R-CFA-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-CFA-5218921: VEGFR2 mediated cell proliferation
R-DRE-114604: GPVI-mediated activation cascade
R-DRE-1257604: PIP3 activates AKT signaling
R-DRE-165158: Activation of AKT2
R-DRE-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-DRE-2871837: FCERI mediated NF-kB activation
R-DRE-389357: CD28 dependent PI3K/Akt signaling
R-DRE-5218920: VEGFR2 mediated vascular permeability
R-DRE-5218921: VEGFR2 mediated cell proliferation
R-DRE-5607764: CLEC7A (Dectin-1) signaling
R-DRE-5625740: RHO GTPases activate PKNs
R-BTA-983231: Factors involved in megakaryocyte development and platelet production
R-MMU-201451: Signaling by BMP
R-MMU-2173788: Downregulation of TGF-beta receptor signaling
R-MMU-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-MMU-4608870: Asymmetric localization of PCP proteins
R-MMU-4641257: Degradation of AXIN
R-MMU-5632684: Hedgehog 'on' state
R-MMU-5689880: Ub-specific processing proteases
R-MMU-8941858: Regulation of RUNX3 expression and activity
R-MMU-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-RNO-446353: Cell-extracellular matrix interactions
R-GGA-375276: Peptide ligand-binding receptors
R-GGA-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-GGA-76009: Platelet Aggregation (Plug Formation)
R-GGA-977606: Regulation of Complement cascade
R-MMU-1660499: Synthesis of PIPs at the plasma membrane
R-RNO-192105: Synthesis of bile acids and bile salts
R-CEL-373752: Netrin-1 signaling
R-CEL-437239: Recycling pathway of L1
R-SSC-114604: GPVI-mediated activation cascade
R-SSC-1433557: Signaling by SCF-KIT
R-SSC-2871796: FCERI mediated MAPK activation
R-SSC-389359: CD28 dependent Vav1 pathway
R-SSC-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-SSC-9027284: Erythropoietin activates RAS
R-SSC-912631: Regulation of signaling by CBL
R-GGA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-GGA-983189: Kinesins
R-GGA-1250347: SHC1 events in ERBB4 signaling
R-GGA-167044: Signalling to RAS
R-GGA-179812: GRB2 events in EGFR signaling
R-GGA-180336: SHC1 events in EGFR signaling
R-GGA-186763: Downstream signal transduction
R-GGA-1963640: GRB2 events in ERBB2 signaling
R-GGA-210993: Tie2 Signaling
R-GGA-2179392: EGFR Transactivation by Gastrin
R-GGA-2428933: SHC-related events triggered by IGF1R
R-GGA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-GGA-5654688: SHC-mediated cascade:FGFR1
R-GGA-5654693: FRS-mediated FGFR1 signaling
R-GGA-5654699: SHC-mediated cascade:FGFR2
R-GGA-5654700: FRS-mediated FGFR2 signaling
R-GGA-5654704: SHC-mediated cascade:FGFR3
R-GGA-5654706: FRS-mediated FGFR3 signaling
R-GGA-5654712: FRS-mediated FGFR4 signaling
R-GGA-5654719: SHC-mediated cascade:FGFR4
R-GGA-8851805: MET activates RAS signaling
R-GGA-8983432: Interleukin-15 signaling
R-GGA-9028731: Activated NTRK2 signals through FRS2 and FRS3
R-GGA-912526: Interleukin receptor SHC signaling
R-CEL-111933: Calmodulin induced events
R-CEL-1250196: SHC1 events in ERBB2 signaling
R-CEL-1489509: DAG and IP3 signaling
R-CEL-202424: Downstream TCR signaling
R-CEL-2029485: Role of phospholipids in phagocytosis
R-CEL-2871837: FCERI mediated NF-kB activation
R-CEL-5218921: VEGFR2 mediated cell proliferation
R-CEL-5607764: CLEC7A (Dectin-1) signaling
R-BTA-1483248: Synthesis of PIPs at the ER membrane
R-BTA-1660517: Synthesis of PIPs at the late endosome membrane
R-XTR-1660499: Synthesis of PIPs at the plasma membrane
R-XTR-1660514: Synthesis of PIPs at the Golgi membrane
R-XTR-1660516: Synthesis of PIPs at the early endosome membrane
R-SSC-1632852: Macroautophagy
R-DRE-2173789: TGF-beta receptor signaling activates SMADs
R-DME-8854214: TBC/RABGAPs
R-CFA-192105: Synthesis of bile acids and bile salts
R-SSC-5610780: Degradation of GLI1 by the proteasome
R-SSC-5632684: Hedgehog 'on' state
R-DRE-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-CFA-111933: Calmodulin induced events
R-CFA-418555: G alpha (s) signalling events
R-CFA-5635838: Activation of SMO
R-GGA-3928665: EPH-ephrin mediated repulsion of cells
R-GGA-5218920: VEGFR2 mediated vascular permeability
R-GGA-1660499: Synthesis of PIPs at the plasma membrane
R-MMU-1632852: Macroautophagy
R-SSC-182971: EGFR downregulation
R-SSC-6807004: Negative regulation of MET activity
R-SSC-2672351: Stimuli-sensing channels
R-SSC-1482922: Acyl chain remodelling of PI
R-SSC-1660514: Synthesis of PIPs at the Golgi membrane
R-RNO-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-RNO-3299685: Detoxification of Reactive Oxygen Species
R-RNO-4420097: VEGFA-VEGFR2 Pathway
R-RNO-5668599: RHO GTPases Activate NADPH Oxidases
R-CEL-2029482: Regulation of actin dynamics for phagocytic cup formation
R-CEL-5627123: RHO GTPases activate PAKs
R-CFA-6798695: Neutrophil degranulation
R-DME-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-CFA-5620912: Anchoring of the basal body to the plasma membrane
R-SSC-202424: Downstream TCR signaling
R-SSC-5689880: Ub-specific processing proteases
R-SSC-5689896: Ovarian tumor domain proteases
R-SSC-8948747: Regulation of PTEN localization
R-DRE-3238698: WNT ligand biogenesis and trafficking
R-MMU-2672351: Stimuli-sensing channels
R-XTR-168138: Toll Like Receptor 9 (TLR9) Cascade
R-SSC-8853659: RET signaling
R-DRE-6794361: Neurexins and neuroligins
R-DRE-1169408: ISG15 antiviral mechanism
R-DRE-186763: Downstream signal transduction
R-DRE-202433: Generation of second messenger molecules
R-DRE-210990: PECAM1 interactions
R-DRE-212718: EGFR interacts with phospholipase C-gamma
R-DRE-2424491: DAP12 signaling
R-DRE-2871796: FCERI mediated MAPK activation
R-DRE-2871809: FCERI mediated Ca+2 mobilization
R-DRE-5654219: Phospholipase C-mediated cascade: FGFR1
R-DRE-5654221: Phospholipase C-mediated cascade; FGFR2
R-DRE-5654227: Phospholipase C-mediated cascade; FGFR3
R-DRE-5654228: Phospholipase C-mediated cascade; FGFR4
R-DRE-8853659: RET signaling
R-DRE-9026527: Activated NTRK2 signals through PLCG1
R-DRE-9034793: Activated NTRK3 signals through PLCG1
R-RNO-1433557: Signaling by SCF-KIT
R-RNO-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5673001: RAF/MAP kinase cascade
R-CFA-5627123: RHO GTPases activate PAKs
R-HSA-114608: Platelet degranulation
R-HSA-140875: Common Pathway of Fibrin Clot Formation
R-HSA-159740: Gamma-carboxylation of protein precursors
R-HSA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-HSA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-977606: Regulation of Complement cascade
R-RNO-2672351: Stimuli-sensing channels
R-SSC-4641258: Degradation of DVL
R-BTA-112043: PLC beta mediated events
R-BTA-1855204: Synthesis of IP3 and IP4 in the cytosol
R-BTA-399997: Acetylcholine regulates insulin secretion
R-BTA-4086398: Ca2+ pathway
R-BTA-418217: G beta:gamma signalling through PLC beta
R-BTA-434316: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-BTA-500657: Presynaptic function of Kainate receptors
R-CFA-2173789: TGF-beta receptor signaling activates SMADs
R-SSC-5625900: RHO GTPases activate CIT
R-DME-6794361: Neurexins and neuroligins
R-MMU-3928662: EPHB-mediated forward signaling
R-MMU-416476: G alpha (q) signalling events
R-MMU-5687128: MAPK6/MAPK4 signaling
R-SSC-5610787: Hedgehog 'off' state
R-SSC-5620912: Anchoring of the basal body to the plasma membrane
R-XTR-6794361: Neurexins and neuroligins
R-SSC-391160: Signal regulatory protein family interactions
R-SSC-9020558: Interleukin-2 signaling
R-XTR-5663213: RHO GTPases Activate WASPs and WAVEs
R-XTR-8964315: G beta:gamma signalling through BTK
R-XTR-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-3928663: EPHA-mediated growth cone collapse
R-SSC-203641: NOSTRIN mediated eNOS trafficking
R-SSC-432720: Lysosome Vesicle Biogenesis
R-XTR-5673000: RAF activation
R-XTR-5674135: MAP2K and MAPK activation
R-XTR-5675221: Negative regulation of MAPK pathway
R-XTR-8875513: MET interacts with TNS proteins
R-MMU-182971: EGFR downregulation
R-MMU-432720: Lysosome Vesicle Biogenesis
R-MMU-6807004: Negative regulation of MET activity
R-MMU-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-RNO-1474228: Degradation of the extracellular matrix
R-CFA-391160: Signal regulatory protein family interactions
R-SSC-416993: Trafficking of GluR2-containing AMPA receptors
R-CFA-75205: Dissolution of Fibrin Clot
R-HSA-1474228: Degradation of the extracellular matrix
R-SSC-165158: Activation of AKT2
R-SSC-165181: Inhibition of TSC complex formation by PKB
R-SSC-111465: Apoptotic cleavage of cellular proteins
R-SSC-2871837: FCERI mediated NF-kB activation
R-SSC-373752: Netrin-1 signaling
R-MMU-1855204: Synthesis of IP3 and IP4 in the cytosol
R-BTA-1474228: Degradation of the extracellular matrix
R-DRE-109704: PI3K Cascade
R-DRE-180292: GAB1 signalosome
R-DRE-1963642: PI3K events in ERBB2 signaling
R-DRE-5654689: PI-3K cascade:FGFR1
R-DRE-5654695: PI-3K cascade:FGFR2
R-DRE-5654710: PI-3K cascade:FGFR3
R-DRE-5654720: PI-3K cascade:FGFR4
R-DRE-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DRE-8851907: MET activates PI3K/AKT signaling
R-DRE-8875555: MET activates RAP1 and RAC1
R-DRE-8875656: MET receptor recycling
R-DRE-9027276: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-XTR-201451: Signaling by BMP
R-XTR-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-XTR-5632684: Hedgehog 'on' state
R-XTR-8941858: Regulation of RUNX3 expression and activity
R-GGA-3928662: EPHB-mediated forward signaling
R-CFA-5610787: Hedgehog 'off' state
R-XTR-190873: Gap junction degradation
R-XTR-196025: Formation of annular gap junctions
R-XTR-437239: Recycling pathway of L1
R-GGA-114516: Disinhibition of SNARE formation
R-GGA-1250196: SHC1 events in ERBB2 signaling
R-GGA-3000170: Syndecan interactions
R-GGA-399997: Acetylcholine regulates insulin secretion
R-GGA-4419969: Depolymerisation of the Nuclear Lamina
R-GGA-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-GGA-5218921: VEGFR2 mediated cell proliferation
R-GGA-76005: Response to elevated platelet cytosolic Ca2+
R-CFA-8854214: TBC/RABGAPs
R-HSA-1483248: Synthesis of PIPs at the ER membrane
R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-RNO-432722: Golgi Associated Vesicle Biogenesis
R-MMU-8875555: MET activates RAP1 and RAC1
R-MMU-983231: Factors involved in megakaryocyte development and platelet production
R-SSC-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-SSC-8957275: Post-translational protein phosphorylation
R-DRE-418594: G alpha (i) signalling events
R-DRE-444473: Formyl peptide receptors bind formyl peptides and many other ligands
R-BTA-5673000: RAF activation
R-BTA-5674135: MAP2K and MAPK activation
R-BTA-5675221: Negative regulation of MAPK pathway
R-XTR-3238698: WNT ligand biogenesis and trafficking
R-XTR-5689880: Ub-specific processing proteases
R-BTA-1295596: Spry regulation of FGF signaling
R-BTA-5674499: Negative feedback regulation of MAPK pathway
R-RNO-201451: Signaling by BMP
R-RNO-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-RNO-4608870: Asymmetric localization of PCP proteins
R-RNO-8941858: Regulation of RUNX3 expression and activity
R-MMU-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-BTA-1660661: Sphingolipid de novo biosynthesis
R-HSA-1989781: PPARA activates gene expression
R-DRE-2453902: The canonical retinoid cycle in rods (twilight vision)
R-MMU-140834: Extrinsic Pathway of Fibrin Clot Formation
R-SSC-983231: Factors involved in megakaryocyte development and platelet production
R-RNO-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-177504: Retrograde neurotrophin signalling
R-HSA-190873: Gap junction degradation
R-HSA-196025: Formation of annular gap junctions
R-HSA-2132295: MHC class II antigen presentation
R-HSA-3928665: EPH-ephrin mediated repulsion of cells
R-HSA-437239: Recycling pathway of L1
R-BTA-5626978: TNFR1-mediated ceramide production
R-GGA-2173788: Downregulation of TGF-beta receptor signaling
R-GGA-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-GGA-4641257: Degradation of AXIN
R-GGA-5632684: Hedgehog 'on' state
R-GGA-5689880: Ub-specific processing proteases
R-GGA-8941858: Regulation of RUNX3 expression and activity
R-XTR-6811438: Intra-Golgi traffic
R-CFA-177504: Retrograde neurotrophin signalling
R-CFA-432720: Lysosome Vesicle Biogenesis
R-XTR-112412: SOS-mediated signalling
R-XTR-1250347: SHC1 events in ERBB4 signaling
R-XTR-167044: Signalling to RAS
R-XTR-179812: GRB2 events in EGFR signaling
R-XTR-180336: SHC1 events in EGFR signaling
R-XTR-1963640: GRB2 events in ERBB2 signaling
R-XTR-2179392: EGFR Transactivation by Gastrin
R-XTR-2428933: SHC-related events triggered by IGF1R
R-XTR-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-XTR-354194: GRB2:SOS provides linkage to MAPK signaling for Integrins
R-XTR-375165: NCAM signaling for neurite out-growth
R-XTR-5654688: SHC-mediated cascade:FGFR1
R-XTR-5654693: FRS-mediated FGFR1 signaling
R-XTR-5654699: SHC-mediated cascade:FGFR2
R-XTR-5654700: FRS-mediated FGFR2 signaling
R-XTR-5654704: SHC-mediated cascade:FGFR3
R-XTR-5654706: FRS-mediated FGFR3 signaling
R-XTR-5654712: FRS-mediated FGFR4 signaling
R-XTR-5654719: SHC-mediated cascade:FGFR4
R-XTR-74749: Signal attenuation
R-XTR-74751: Insulin receptor signalling cascade
R-XTR-8851805: MET activates RAS signaling
R-XTR-9028731: Activated NTRK2 signals through FRS2 and FRS3
R-DME-193634: Axonal growth inhibition (RHOA activation)
R-DME-193648: NRAGE signals death through JNK
R-DME-194840: Rho GTPase cycle
R-PFA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-BTA-3238698: WNT ligand biogenesis and trafficking
R-BTA-5689880: Ub-specific processing proteases
R-GGA-140834: Extrinsic Pathway of Fibrin Clot Formation
R-DME-8866427: VLDLR internalisation and degradation
R-DME-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-RNO-1257604: PIP3 activates AKT signaling
R-RNO-165158: Activation of AKT2
R-RNO-165181: Inhibition of TSC complex formation by PKB
R-RNO-198323: AKT phosphorylates targets in the cytosol
R-RNO-198693: AKT phosphorylates targets in the nucleus
R-RNO-199418: Negative regulation of the PI3K/AKT network
R-RNO-3769402: Deactivation of the beta-catenin transactivating complex
R-RNO-389357: CD28 dependent PI3K/Akt signaling
R-RNO-389513: CTLA4 inhibitory signaling
R-RNO-392451: G beta:gamma signalling through PI3Kgamma
R-RNO-5218920: VEGFR2 mediated vascular permeability
R-RNO-6804757: Regulation of TP53 Degradation
R-RNO-6804758: Regulation of TP53 Activity through Acetylation
R-MMU-432722: Golgi Associated Vesicle Biogenesis
R-GGA-8951664: Neddylation
R-RNO-181429: Serotonin Neurotransmitter Release Cycle
R-RNO-181430: Norepinephrine Neurotransmitter Release Cycle
R-RNO-210500: Glutamate Neurotransmitter Release Cycle
R-RNO-212676: Dopamine Neurotransmitter Release Cycle
R-RNO-264642: Acetylcholine Neurotransmitter Release Cycle
R-RNO-888590: GABA synthesis, release, reuptake and degradation
R-BTA-114604: GPVI-mediated activation cascade
R-BTA-202424: Downstream TCR signaling
R-BTA-5625740: RHO GTPases activate PKNs
R-BTA-5627123: RHO GTPases activate PAKs
R-DRE-203641: NOSTRIN mediated eNOS trafficking
R-DRE-432720: Lysosome Vesicle Biogenesis
R-DME-6798695: Neutrophil degranulation
R-MMU-1295596: Spry regulation of FGF signaling
R-MMU-5673000: RAF activation
R-MMU-5674135: MAP2K and MAPK activation
R-MMU-5674499: Negative feedback regulation of MAPK pathway
R-MMU-5675221: Negative regulation of MAPK pathway
R-DME-111465: Apoptotic cleavage of cellular proteins
R-DME-2424491: DAP12 signaling
R-DME-2871809: FCERI mediated Ca+2 mobilization
R-DME-416476: G alpha (q) signalling events
R-DME-416482: G alpha (12/13) signalling events
R-DME-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-3928664: Ephrin signaling
R-DRE-5687128: MAPK6/MAPK4 signaling
R-GGA-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-CFA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-CFA-204005: COPII-mediated vesicle transport
R-CFA-5694530: Cargo concentration in the ER
R-HSA-192105: Synthesis of bile acids and bile salts
R-XTR-5610787: Hedgehog 'off' state
R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-SSC-112412: SOS-mediated signalling
R-SSC-1250347: SHC1 events in ERBB4 signaling
R-SSC-1433559: Regulation of KIT signaling
R-SSC-167044: Signalling to RAS
R-SSC-179812: GRB2 events in EGFR signaling
R-SSC-180336: SHC1 events in EGFR signaling
R-SSC-186763: Downstream signal transduction
R-SSC-1963640: GRB2 events in ERBB2 signaling
R-SSC-210993: Tie2 Signaling
R-SSC-2179392: EGFR Transactivation by Gastrin
R-SSC-2428933: SHC-related events triggered by IGF1R
R-SSC-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-SSC-375165: NCAM signaling for neurite out-growth
R-SSC-5654688: SHC-mediated cascade:FGFR1
R-SSC-5654693: FRS-mediated FGFR1 signaling
R-SSC-5654699: SHC-mediated cascade:FGFR2
R-SSC-5654700: FRS-mediated FGFR2 signaling
R-SSC-5654704: SHC-mediated cascade:FGFR3
R-SSC-5654706: FRS-mediated FGFR3 signaling
R-SSC-5654712: FRS-mediated FGFR4 signaling
R-SSC-5654719: SHC-mediated cascade:FGFR4
R-SSC-74749: Signal attenuation
R-SSC-74751: Insulin receptor signalling cascade
R-SSC-8851805: MET activates RAS signaling
R-SSC-8983432: Interleukin-15 signaling
R-SSC-9028731: Activated NTRK2 signals through FRS2 and FRS3
R-SSC-912526: Interleukin receptor SHC signaling
R-GGA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-SSC-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-SSC-983189: Kinesins
R-DME-1483166: Synthesis of PA
R-XTR-1295596: Spry regulation of FGF signaling
R-XTR-5674499: Negative feedback regulation of MAPK pathway
R-SSC-3928664: Ephrin signaling
R-BTA-1170546: Prolactin receptor signaling
R-BTA-982772: Growth hormone receptor signaling
R-BTA-193634: Axonal growth inhibition (RHOA activation)
R-RNO-418885: DCC mediated attractive signaling
R-CEL-983189: Kinesins
R-HSA-1483206: Glycerophospholipid biosynthesis
R-GGA-180292: GAB1 signalosome
R-GGA-1963642: PI3K events in ERBB2 signaling
R-GGA-5654689: PI-3K cascade:FGFR1
R-GGA-5654695: PI-3K cascade:FGFR2
R-GGA-5654710: PI-3K cascade:FGFR3
R-GGA-5654720: PI-3K cascade:FGFR4
R-GGA-8851907: MET activates PI3K/AKT signaling
R-GGA-8865999: MET activates PTPN11
R-GGA-8875555: MET activates RAP1 and RAC1
R-GGA-8875656: MET receptor recycling
R-SSC-2173788: Downregulation of TGF-beta receptor signaling
R-SSC-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-SSC-4608870: Asymmetric localization of PCP proteins
R-SSC-4641257: Degradation of AXIN
R-SSC-8941858: Regulation of RUNX3 expression and activity
R-SSC-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-MMU-1912408: Pre-NOTCH Transcription and Translation
R-MMU-209543: p75NTR recruits signalling complexes
R-MMU-420029: Tight junction interactions
R-DRE-8875513: MET interacts with TNS proteins
R-RNO-5626978: TNFR1-mediated ceramide production
R-SSC-6811440: Retrograde transport at the Trans-Golgi-Network
R-DDI-6798695: Neutrophil degranulation
R-RNO-109704: PI3K Cascade
R-RNO-180292: GAB1 signalosome
R-RNO-1963642: PI3K events in ERBB2 signaling
R-RNO-5654689: PI-3K cascade:FGFR1
R-RNO-5654695: PI-3K cascade:FGFR2
R-RNO-5654710: PI-3K cascade:FGFR3
R-RNO-5654720: PI-3K cascade:FGFR4
R-RNO-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8851907: MET activates PI3K/AKT signaling
R-RNO-8853659: RET signaling
R-RNO-8865999: MET activates PTPN11
R-RNO-8875555: MET activates RAP1 and RAC1
R-RNO-8875656: MET receptor recycling
R-RNO-9027276: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-RNO-2173789: TGF-beta receptor signaling activates SMADs
R-GGA-1295596: Spry regulation of FGF signaling
R-BTA-2132295: MHC class II antigen presentation
R-BTA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-BTA-983189: Kinesins
R-DRE-6798695: Neutrophil degranulation
R-DRE-75205: Dissolution of Fibrin Clot
R-DRE-3928665: EPH-ephrin mediated repulsion of cells
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189: Kinesins
R-SPO-6804757: Regulation of TP53 Degradation
R-MMU-5673001: RAF/MAP kinase cascade
R-CFA-1660514: Synthesis of PIPs at the Golgi membrane
R-BTA-416482: G alpha (12/13) signalling events
R-GGA-190873: Gap junction degradation
R-GGA-196025: Formation of annular gap junctions
R-GGA-2132295: MHC class II antigen presentation
R-GGA-437239: Recycling pathway of L1
R-CFA-1660662: Glycosphingolipid metabolism
R-BTA-192105: Synthesis of bile acids and bile salts
R-RNO-114604: GPVI-mediated activation cascade
R-RNO-2871796: FCERI mediated MAPK activation
R-RNO-389359: CD28 dependent Vav1 pathway
R-RNO-9027284: Erythropoietin activates RAS
R-RNO-912631: Regulation of signaling by CBL
R-BTA-3928665: EPH-ephrin mediated repulsion of cells
R-XTR-418889: Caspase activation via Dependence Receptors in the absence of ligand
R-DME-354192: Integrin alphaIIb beta3 signaling
R-DME-5674135: MAP2K and MAPK activation
R-SPO-983231: Factors involved in megakaryocyte development and platelet production
R-DME-3928662: EPHB-mediated forward signaling
R-DME-3928665: EPH-ephrin mediated repulsion of cells
R-RNO-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-RNO-3928665: EPH-ephrin mediated repulsion of cells
R-CFA-1912408: Pre-NOTCH Transcription and Translation
R-CFA-209543: p75NTR recruits signalling complexes
R-CFA-420029: Tight junction interactions
R-CFA-418889: Caspase activation via Dependence Receptors in the absence of ligand
R-GGA-202433: Generation of second messenger molecules
R-GGA-5654219: Phospholipase C-mediated cascade: FGFR1
R-GGA-5654228: Phospholipase C-mediated cascade; FGFR4
R-GGA-9026527: Activated NTRK2 signals through PLCG1
R-BTA-5687128: MAPK6/MAPK4 signaling
R-CFA-199418: Negative regulation of the PI3K/AKT network
R-CFA-202424: Downstream TCR signaling
R-CFA-5689880: Ub-specific processing proteases
R-CFA-5689896: Ovarian tumor domain proteases
R-CFA-8948747: Regulation of PTEN localization
R-CFA-8948751: Regulation of PTEN stability and activity
R-DME-1483248: Synthesis of PIPs at the ER membrane
R-DME-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-5620916: VxPx cargo-targeting to cilium
R-DRE-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-DRE-1170546: Prolactin receptor signaling
R-DRE-982772: Growth hormone receptor signaling
R-MMU-140837: Intrinsic Pathway of Fibrin Clot Formation
R-GGA-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-GGA-3299685: Detoxification of Reactive Oxygen Species
R-RNO-5610787: Hedgehog 'off' state
R-CFA-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-DRE-140837: Intrinsic Pathway of Fibrin Clot Formation
R-DME-8856825: Cargo recognition for clathrin-mediated endocytosis
R-SSC-140834: Extrinsic Pathway of Fibrin Clot Formation
R-SSC-140837: Intrinsic Pathway of Fibrin Clot Formation
R-RNO-1295596: Spry regulation of FGF signaling
R-RNO-5674499: Negative feedback regulation of MAPK pathway
R-XTR-1482925: Acyl chain remodelling of PG
R-RNO-5607764: CLEC7A (Dectin-1) signaling
R-DRE-1482801: Acyl chain remodelling of PS
R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-SCE-192105: Synthesis of bile acids and bile salts
R-CEL-6794361: Neurexins and neuroligins
R-SSC-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-HSA-5083635: Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214: O-glycosylation of TSR domain-containing proteins
R-CFA-5687128: MAPK6/MAPK4 signaling
R-MMU-3238698: WNT ligand biogenesis and trafficking
R-DRE-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-DRE-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-GGA-9020558: Interleukin-2 signaling
R-XTR-375276: Peptide ligand-binding receptors
R-XTR-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-XTR-76009: Platelet Aggregation (Plug Formation)
R-XTR-977606: Regulation of Complement cascade
R-SSC-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-SSC-445355: Smooth Muscle Contraction
R-CEL-1660661: Sphingolipid de novo biosynthesis
R-XTR-182971: EGFR downregulation
R-XTR-5620912: Anchoring of the basal body to the plasma membrane
R-MMU-1170546: Prolactin receptor signaling
R-MMU-982772: Growth hormone receptor signaling
R-XTR-1660661: Sphingolipid de novo biosynthesis
R-CFA-1257604: PIP3 activates AKT signaling
R-CFA-1433557: Signaling by SCF-KIT
R-CFA-389359: CD28 dependent Vav1 pathway
R-CFA-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-CFA-5218920: VEGFR2 mediated vascular permeability
R-CFA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CFA-9027284: Erythropoietin activates RAS
R-CFA-912631: Regulation of signaling by CBL
R-SSC-8866427: VLDLR internalisation and degradation
R-MMU-112412: SOS-mediated signalling
R-MMU-1250347: SHC1 events in ERBB4 signaling
R-MMU-1433559: Regulation of KIT signaling
R-MMU-167044: Signalling to RAS
R-MMU-179812: GRB2 events in EGFR signaling
R-MMU-180336: SHC1 events in EGFR signaling
R-MMU-186763: Downstream signal transduction
R-MMU-1963640: GRB2 events in ERBB2 signaling
R-MMU-210993: Tie2 Signaling
R-MMU-2179392: EGFR Transactivation by Gastrin
R-MMU-2428933: SHC-related events triggered by IGF1R
R-MMU-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-354194: GRB2:SOS provides linkage to MAPK signaling for Integrins
R-MMU-375165: NCAM signaling for neurite out-growth
R-MMU-5654688: SHC-mediated cascade:FGFR1
R-MMU-5654693: FRS-mediated FGFR1 signaling
R-MMU-5654699: SHC-mediated cascade:FGFR2
R-MMU-5654700: FRS-mediated FGFR2 signaling
R-MMU-5654704: SHC-mediated cascade:FGFR3
R-MMU-5654706: FRS-mediated FGFR3 signaling
R-MMU-5654712: FRS-mediated FGFR4 signaling
R-MMU-5654719: SHC-mediated cascade:FGFR4
R-MMU-74749: Signal attenuation
R-MMU-74751: Insulin receptor signalling cascade
R-MMU-8851805: MET activates RAS signaling
R-MMU-8853659: RET signaling
R-MMU-8983432: Interleukin-15 signaling
R-MMU-9028731: Activated NTRK2 signals through FRS2 and FRS3
R-MMU-912526: Interleukin receptor SHC signaling
R-DME-112043: PLC beta mediated events
R-GGA-2028269: Signaling by Hippo
R-DRE-1660517: Synthesis of PIPs at the late endosome membrane
R-MMU-140875: Common Pathway of Fibrin Clot Formation
R-MMU-202733: Cell surface interactions at the vascular wall
R-XTR-373752: Netrin-1 signaling
R-XTR-8964026: Chylomicron clearance
R-XTR-8964038: LDL clearance
R-DRE-9020558: Interleukin-2 signaling
R-RNO-112399: IRS-mediated signalling
R-RNO-112412: SOS-mediated signalling
R-RNO-1266695: Interleukin-7 signaling
R-RNO-198203: PI3K/AKT activation
R-RNO-2428928: IRS-related events triggered by IGF1R
R-RNO-74713: IRS activation
R-RNO-74749: Signal attenuation
R-BTA-3928663: EPHA-mediated growth cone collapse
R-RNO-418555: G alpha (s) signalling events
R-HSA-416572: Sema4D induced cell migration and growth-cone collapse
R-BTA-445355: Smooth Muscle Contraction
R-CFA-210993: Tie2 Signaling
R-DRE-6807878: COPI-mediated anterograde transport
R-BTA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-XTR-9020558: Interleukin-2 signaling
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-8964026: Chylomicron clearance
R-HSA-8964038: LDL clearance
R-CFA-1295596: Spry regulation of FGF signaling
R-CEL-1855204: Synthesis of IP3 and IP4 in the cytosol
R-RNO-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275: Post-translational protein phosphorylation
R-SSC-5627123: RHO GTPases activate PAKs
R-XTR-109704: PI3K Cascade
R-XTR-1632852: Macroautophagy
R-RNO-202433: Generation of second messenger molecules
R-BTA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-XTR-1660517: Synthesis of PIPs at the late endosome membrane
R-HSA-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-DME-216083: Integrin cell surface interactions
R-DME-5173214: O-glycosylation of TSR domain-containing proteins
R-DME-913709: O-linked glycosylation of mucins
R-DME-977068: Termination of O-glycan biosynthesis
R-PFA-192105: Synthesis of bile acids and bile salts
R-GGA-432722: Golgi Associated Vesicle Biogenesis
R-GGA-8875513: MET interacts with TNS proteins
R-RNO-5625900: RHO GTPases activate CIT
R-RNO-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-GGA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-MMU-2028269: Signaling by Hippo
R-DRE-1482788: Acyl chain remodelling of PC
R-DRE-1482839: Acyl chain remodelling of PE
R-DRE-1482922: Acyl chain remodelling of PI
R-DRE-1482925: Acyl chain remodelling of PG
R-DRE-1483115: Hydrolysis of LPC
R-DRE-1483166: Synthesis of PA
R-MMU-193634: Axonal growth inhibition (RHOA activation)
R-RNO-74751: Insulin receptor signalling cascade
R-CFA-4608870: Asymmetric localization of PCP proteins
R-CFA-8941858: Regulation of RUNX3 expression and activity
R-SSC-6811438: Intra-Golgi traffic
R-BTA-1482788: Acyl chain remodelling of PC
R-BTA-1482801: Acyl chain remodelling of PS
R-BTA-1482839: Acyl chain remodelling of PE
R-BTA-1482922: Acyl chain remodelling of PI
R-BTA-1482925: Acyl chain remodelling of PG
R-BTA-1483115: Hydrolysis of LPC
R-BTA-1483166: Synthesis of PA
R-XTR-6807004: Negative regulation of MET activity
R-CFA-1169408: ISG15 antiviral mechanism
R-CFA-186763: Downstream signal transduction
R-CFA-210990: PECAM1 interactions
R-CFA-212718: EGFR interacts with phospholipase C-gamma
R-CFA-5654219: Phospholipase C-mediated cascade: FGFR1
R-CFA-5654221: Phospholipase C-mediated cascade; FGFR2
R-CFA-5654227: Phospholipase C-mediated cascade; FGFR3
R-CFA-5654228: Phospholipase C-mediated cascade; FGFR4
R-CFA-8853659: RET signaling
R-CFA-9026527: Activated NTRK2 signals through PLCG1
R-CFA-9034793: Activated NTRK3 signals through PLCG1
R-SSC-5620916: VxPx cargo-targeting to cilium
R-XTR-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-5626978: TNFR1-mediated ceramide production
R-CFA-181429: Serotonin Neurotransmitter Release Cycle
R-CFA-181430: Norepinephrine Neurotransmitter Release Cycle
R-CFA-210500: Glutamate Neurotransmitter Release Cycle
R-CFA-212676: Dopamine Neurotransmitter Release Cycle
R-CFA-264642: Acetylcholine Neurotransmitter Release Cycle
R-CFA-888590: GABA synthesis, release, reuptake and degradation
R-CFA-1483248: Synthesis of PIPs at the ER membrane
R-DDI-354192: Integrin alphaIIb beta3 signaling
R-DDI-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-DDI-392517: Rap1 signalling
R-DDI-5673001: RAF/MAP kinase cascade
R-CFA-2028269: Signaling by Hippo
R-BTA-5689896: Ovarian tumor domain proteases
R-BTA-8948747: Regulation of PTEN localization
R-BTA-8948751: Regulation of PTEN stability and activity
R-CEL-416482: G alpha (12/13) signalling events
R-RNO-1660514: Synthesis of PIPs at the Golgi membrane
R-SSC-9020702: Interleukin-1 signaling
R-GGA-165158: Activation of AKT2
R-GGA-202424: Downstream TCR signaling
R-GGA-389357: CD28 dependent PI3K/Akt signaling
R-GGA-5625740: RHO GTPases activate PKNs
R-XTR-5658442: Regulation of RAS by GAPs
R-SSC-109704: PI3K Cascade
R-SSC-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-SSC-5607764: CLEC7A (Dectin-1) signaling
R-SSC-877300: Interferon gamma signaling
R-MMU-1169092: Activation of RAS in B cells
R-DDI-2029482: Regulation of actin dynamics for phagocytic cup formation
R-DDI-389359: CD28 dependent Vav1 pathway
R-DDI-3928662: EPHB-mediated forward signaling
R-DDI-445144: Signal transduction by L1
R-DDI-5621575: CD209 (DC-SIGN) signaling
R-DDI-5627123: RHO GTPases activate PAKs
R-DDI-5687128: MAPK6/MAPK4 signaling
R-MMU-5620912: Anchoring of the basal body to the plasma membrane
R-DME-111933: Calmodulin induced events
R-DME-5635838: Activation of SMO
R-SSC-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-SSC-8964616: G beta:gamma signalling through CDC42
R-MMU-112043: PLC beta mediated events
R-MMU-399997: Acetylcholine regulates insulin secretion
R-MMU-4086398: Ca2+ pathway
R-MMU-418217: G beta:gamma signalling through PLC beta
R-MMU-434316: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-MMU-500657: Presynaptic function of Kainate receptors
R-BTA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-8957275: Post-translational protein phosphorylation
R-GGA-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-GGA-8964616: G beta:gamma signalling through CDC42
R-HSA-4641258: Degradation of DVL
R-XTR-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-XTR-8964616: G beta:gamma signalling through CDC42
R-CFA-1169092: Activation of RAS in B cells
R-CFA-4086398: Ca2+ pathway
R-CFA-418217: G beta:gamma signalling through PLC beta
R-CFA-500657: Presynaptic function of Kainate receptors
R-BTA-3000171: Non-integrin membrane-ECM interactions
R-SSC-193634: Axonal growth inhibition (RHOA activation)
R-XTR-2173788: Downregulation of TGF-beta receptor signaling
R-XTR-4641257: Degradation of AXIN
R-XTR-416482: G alpha (12/13) signalling events
R-CFA-373752: Netrin-1 signaling
R-BTA-9020702: Interleukin-1 signaling
R-MMU-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275: Post-translational protein phosphorylation
R-XTR-416572: Sema4D induced cell migration and growth-cone collapse
R-DRE-8951664: Neddylation
R-DRE-202733: Cell surface interactions at the vascular wall
R-RNO-1483206: Glycerophospholipid biosynthesis
R-RNO-166016: Toll Like Receptor 4 (TLR4) Cascade
R-DRE-5620924: Intraflagellar transport
R-CFA-5668599: RHO GTPases Activate NADPH Oxidases
R-BTA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-CFA-9020558: Interleukin-2 signaling
R-RNO-75205: Dissolution of Fibrin Clot
R-DRE-912526: Interleukin receptor SHC signaling
R-DRE-912631: Regulation of signaling by CBL
R-MMU-4641258: Degradation of DVL
R-DRE-5668599: RHO GTPases Activate NADPH Oxidases
R-CFA-6794361: Neurexins and neuroligins
R-XTR-389359: CD28 dependent Vav1 pathway
R-XTR-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-XTR-9027284: Erythropoietin activates RAS
R-XTR-912631: Regulation of signaling by CBL
R-RNO-1660661: Sphingolipid de novo biosynthesis
R-GGA-111465: Apoptotic cleavage of cellular proteins
R-GGA-1489509: DAG and IP3 signaling
R-GGA-877300: Interferon gamma signaling
R-CFA-399719: Trafficking of AMPA receptors
R-CEL-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-BTA-1169408: ISG15 antiviral mechanism
R-BTA-202433: Generation of second messenger molecules
R-BTA-210990: PECAM1 interactions
R-BTA-212718: EGFR interacts with phospholipase C-gamma
R-BTA-5654219: Phospholipase C-mediated cascade: FGFR1
R-BTA-5654221: Phospholipase C-mediated cascade; FGFR2
R-BTA-5654227: Phospholipase C-mediated cascade; FGFR3
R-BTA-5654228: Phospholipase C-mediated cascade; FGFR4
R-BTA-9026527: Activated NTRK2 signals through PLCG1
R-BTA-9034793: Activated NTRK3 signals through PLCG1
R-CFA-8951664: Neddylation
R-CFA-1482922: Acyl chain remodelling of PI
R-DRE-3000171: Non-integrin membrane-ECM interactions
R-BTA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-DRE-201451: Signaling by BMP
R-SCE-194840: Rho GTPase cycle
R-SCE-416482: G alpha (12/13) signalling events
R-BTA-112399: IRS-mediated signalling
R-BTA-1266695: Interleukin-7 signaling
R-BTA-198203: PI3K/AKT activation
R-BTA-2428928: IRS-related events triggered by IGF1R
R-BTA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-209190: Phosphorylation of CI
R-DME-209214: Phosphorylation of SMO
R-DME-432553: Phosphorylation of PER and TIM
R-SSC-194306: Neurophilin interactions with VEGF and VEGFR
R-SSC-399954: Sema3A PAK dependent Axon repulsion
R-SSC-399956: CRMPs in Sema3A signaling
R-SSC-445144: Signal transduction by L1
R-RNO-3928662: EPHB-mediated forward signaling
R-RNO-5687128: MAPK6/MAPK4 signaling
R-SCE-114604: GPVI-mediated activation cascade
R-SCE-4420097: VEGFA-VEGFR2 Pathway
R-SCE-5218920: VEGFR2 mediated vascular permeability
R-SSC-1169408: ISG15 antiviral mechanism
R-SSC-202433: Generation of second messenger molecules
R-SSC-210990: PECAM1 interactions
R-SSC-212718: EGFR interacts with phospholipase C-gamma
R-SSC-5654219: Phospholipase C-mediated cascade: FGFR1
R-SSC-5654228: Phospholipase C-mediated cascade; FGFR4
R-SSC-9026527: Activated NTRK2 signals through PLCG1
R-HSA-1855204: Synthesis of IP3 and IP4 in the cytosol
R-GGA-1483206: Glycerophospholipid biosynthesis
R-DME-432720: Lysosome Vesicle Biogenesis
R-DME-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-418555: G alpha (s) signalling events
R-RNO-392517: Rap1 signalling
R-RNO-430116: GP1b-IX-V activation signalling
R-RNO-5621575: CD209 (DC-SIGN) signaling
R-DME-201451: Signaling by BMP
R-DME-2173789: TGF-beta receptor signaling activates SMADs
R-MMU-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189: Kinesins
R-GGA-8866427: VLDLR internalisation and degradation
R-DDI-8856828: Clathrin-mediated endocytosis
R-BTA-8866427: VLDLR internalisation and degradation
R-XTR-5610780: Degradation of GLI1 by the proteasome
R-DRE-1632852: Macroautophagy
R-CFA-446353: Cell-extracellular matrix interactions
R-HSA-114604: GPVI-mediated activation cascade
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2871809: FCERI mediated Ca+2 mobilization
R-HSA-389359: CD28 dependent Vav1 pathway
R-HSA-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5218920: VEGFR2 mediated vascular permeability
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9027284: Erythropoietin activates RAS
R-HSA-912631: Regulation of signaling by CBL
R-HSA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-GGA-6811438: Intra-Golgi traffic
R-CEL-1433559: Regulation of KIT signaling
R-CEL-167044: Signalling to RAS
R-CEL-179812: GRB2 events in EGFR signaling
R-CEL-180336: SHC1 events in EGFR signaling
R-CEL-1963640: GRB2 events in ERBB2 signaling
R-CEL-2179392: EGFR Transactivation by Gastrin
R-CEL-375165: NCAM signaling for neurite out-growth
R-CEL-5654699: SHC-mediated cascade:FGFR2
R-CEL-5654700: FRS-mediated FGFR2 signaling
R-CEL-5654704: SHC-mediated cascade:FGFR3
R-CEL-5654706: FRS-mediated FGFR3 signaling
R-CEL-74751: Insulin receptor signalling cascade
R-CEL-8851805: MET activates RAS signaling
R-MMU-392517: Rap1 signalling
R-MMU-430116: GP1b-IX-V activation signalling
R-MMU-5621575: CD209 (DC-SIGN) signaling
R-BTA-5620912: Anchoring of the basal body to the plasma membrane
R-RNO-399997: Acetylcholine regulates insulin secretion
R-RNO-4086398: Ca2+ pathway
R-RNO-418217: G beta:gamma signalling through PLC beta
R-RNO-434316: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-RNO-500657: Presynaptic function of Kainate receptors
R-XTR-372708: p130Cas linkage to MAPK signaling for integrins
R-GGA-199418: Negative regulation of the PI3K/AKT network
R-GGA-5689896: Ovarian tumor domain proteases
R-RNO-111933: Calmodulin induced events
R-RNO-114516: Disinhibition of SNARE formation
R-RNO-1250196: SHC1 events in ERBB2 signaling
R-RNO-1433559: Regulation of KIT signaling
R-RNO-2179392: EGFR Transactivation by Gastrin
R-RNO-3000170: Syndecan interactions
R-RNO-4419969: Depolymerisation of the Nuclear Lamina
R-RNO-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-RNO-5099900: WNT5A-dependent internalization of FZD4
R-RNO-5218921: VEGFR2 mediated cell proliferation
R-RNO-76005: Response to elevated platelet cytosolic Ca2+
R-SSC-1253288: Downregulation of ERBB4 signaling
R-XTR-8854214: TBC/RABGAPs
R-BTA-201451: Signaling by BMP
R-XTR-5620924: Intraflagellar transport
R-XTR-5173214: O-glycosylation of TSR domain-containing proteins
R-SSC-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-SSC-3299685: Detoxification of Reactive Oxygen Species
R-SSC-5668599: RHO GTPases Activate NADPH Oxidases
R-CEL-418885: DCC mediated attractive signaling
R-CEL-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-CEL-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-3928662: EPHB-mediated forward signaling
R-DRE-1474228: Degradation of the extracellular matrix
R-DME-983189: Kinesins
R-GGA-112043: PLC beta mediated events
R-GGA-4086398: Ca2+ pathway
R-GGA-418217: G beta:gamma signalling through PLC beta
R-GGA-500657: Presynaptic function of Kainate receptors
R-CFA-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-GGA-1912408: Pre-NOTCH Transcription and Translation
R-RNO-168138: Toll Like Receptor 9 (TLR9) Cascade
R-DRE-418889: Caspase activation via Dependence Receptors in the absence of ligand
R-MMU-8941237: Invadopodia formation
R-CFA-418594: G alpha (i) signalling events
R-CFA-3928664: Ephrin signaling
R-HSA-1295596: Spry regulation of FGF signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-170984: ARMS-mediated activation
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-5673000: RAF activation
R-HSA-5674135: MAP2K and MAPK activation
R-HSA-5674499: Negative feedback regulation of MAPK pathway
R-HSA-5675221: Negative regulation of MAPK pathway
R-HSA-6802946: Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948: Signaling by high-kinase activity BRAF mutants
R-HSA-6802949: Signaling by RAS mutants
R-HSA-6802952: Signaling by BRAF and RAF fusions
R-HSA-6802955: Paradoxical activation of RAF signaling by kinase inactive BRAF
R-CFA-1250196: SHC1 events in ERBB2 signaling
R-CFA-1489509: DAG and IP3 signaling
R-HSA-111465: Apoptotic cleavage of cellular proteins
R-DRE-5627117: RHO GTPases Activate ROCKs
R-CFA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-109704: PI3K Cascade
R-HSA-1839117: Signaling by cytosolic FGFR1 fusion mutants
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-8853659: RET signaling
R-HSA-8983432: Interleukin-15 signaling
R-HSA-912526: Interleukin receptor SHC signaling
R-RNO-354192: Integrin alphaIIb beta3 signaling
R-RNO-354194: GRB2:SOS provides linkage to MAPK signaling for Integrins
R-RNO-372708: p130Cas linkage to MAPK signaling for integrins
R-RNO-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-RNO-445355: Smooth Muscle Contraction
R-RNO-190873: Gap junction degradation
R-RNO-196025: Formation of annular gap junctions
R-RNO-140837: Intrinsic Pathway of Fibrin Clot Formation
R-RNO-204005: COPII-mediated vesicle transport
R-RNO-5694530: Cargo concentration in the ER
R-XTR-74713: IRS activation
R-DRE-165181: Inhibition of TSC complex formation by PKB
R-DRE-3769402: Deactivation of the beta-catenin transactivating complex
R-MMU-109704: PI3K Cascade
R-MMU-112399: IRS-mediated signalling
R-MMU-1266695: Interleukin-7 signaling
R-MMU-198203: PI3K/AKT activation
R-MMU-2428928: IRS-related events triggered by IGF1R
R-MMU-74713: IRS activation
R-MMU-202424: Downstream TCR signaling
R-MMU-5689896: Ovarian tumor domain proteases
R-MMU-8948747: Regulation of PTEN localization
R-CFA-9020702: Interleukin-1 signaling
R-RNO-8951664: Neddylation
R-HSA-112043: PLC beta mediated events
R-HSA-399997: Acetylcholine regulates insulin secretion
R-HSA-4086398: Ca2+ pathway
R-HSA-416476: G alpha (q) signalling events
R-HSA-418217: G beta:gamma signalling through PLC beta
R-HSA-434316: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-500657: Presynaptic function of Kainate receptors
R-BTA-5625900: RHO GTPases activate CIT
R-MMU-2173789: TGF-beta receptor signaling activates SMADs
R-HSA-182971: EGFR downregulation
R-HSA-3928664: Ephrin signaling
R-HSA-9619229: Activation of RAC1 downstream of NMDARs
R-CFA-416572: Sema4D induced cell migration and growth-cone collapse
R-CFA-198323: AKT phosphorylates targets in the cytosol
R-CFA-198693: AKT phosphorylates targets in the nucleus
R-CFA-389357: CD28 dependent PI3K/Akt signaling
R-CFA-392451: G beta:gamma signalling through PI3Kgamma
R-CFA-6804757: Regulation of TP53 Degradation
R-CFA-6804758: Regulation of TP53 Activity through Acetylation
R-GGA-5626978: TNFR1-mediated ceramide production
R-GGA-3238698: WNT ligand biogenesis and trafficking
R-CFA-109704: PI3K Cascade
R-CFA-180292: GAB1 signalosome
R-CFA-1963642: PI3K events in ERBB2 signaling
R-CFA-5654689: PI-3K cascade:FGFR1
R-CFA-5654695: PI-3K cascade:FGFR2
R-CFA-5654710: PI-3K cascade:FGFR3
R-CFA-5654720: PI-3K cascade:FGFR4
R-CFA-8851907: MET activates PI3K/AKT signaling
R-CFA-8865999: MET activates PTPN11
R-CFA-8875555: MET activates RAP1 and RAC1
R-CFA-8875656: MET receptor recycling
R-CFA-9027276: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-BTA-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-BTA-8964616: G beta:gamma signalling through CDC42
R-CFA-2871837: FCERI mediated NF-kB activation
R-CFA-445355: Smooth Muscle Contraction
R-XTR-418594: G alpha (i) signalling events
R-XTR-444473: Formyl peptide receptors bind formyl peptides and many other ligands
R-GGA-5687128: MAPK6/MAPK4 signaling
R-CFA-1632852: Macroautophagy
R-HSA-428540: Activation of RAC1
R-BTA-430116: GP1b-IX-V activation signalling
R-BTA-5621575: CD209 (DC-SIGN) signaling
R-MMU-375276: Peptide ligand-binding receptors
R-MMU-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-76009: Platelet Aggregation (Plug Formation)
R-MMU-977606: Regulation of Complement cascade
R-HSA-2672351: Stimuli-sensing channels
R-DDI-1632852: Macroautophagy
R-DDI-1660516: Synthesis of PIPs at the early endosome membrane
R-DDI-5668599: RHO GTPases Activate NADPH Oxidases
R-MMU-168138: Toll Like Receptor 9 (TLR9) Cascade
R-DME-1433559: Regulation of KIT signaling
R-DME-983231: Factors involved in megakaryocyte development and platelet production
R-MMU-180292: GAB1 signalosome
R-MMU-1963642: PI3K events in ERBB2 signaling
R-MMU-5654689: PI-3K cascade:FGFR1
R-MMU-5654695: PI-3K cascade:FGFR2
R-MMU-5654710: PI-3K cascade:FGFR3
R-MMU-5654720: PI-3K cascade:FGFR4
R-MMU-8851907: MET activates PI3K/AKT signaling
R-MMU-8865999: MET activates PTPN11
R-MMU-8875656: MET receptor recycling
R-MMU-9027276: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-BTA-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-BTA-165159: mTOR signalling
R-BTA-203615: eNOS activation
R-BTA-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-193634: Axonal growth inhibition (RHOA activation)
R-GGA-5620924: Intraflagellar transport
R-BTA-418555: G alpha (s) signalling events
R-BTA-5635838: Activation of SMO
R-MMU-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-BTA-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-DRE-5627123: RHO GTPases activate PAKs
R-XTR-193634: Axonal growth inhibition (RHOA activation)
R-BTA-180292: GAB1 signalosome
R-BTA-1963642: PI3K events in ERBB2 signaling
R-BTA-5654689: PI-3K cascade:FGFR1
R-BTA-5654695: PI-3K cascade:FGFR2
R-BTA-5654710: PI-3K cascade:FGFR3
R-BTA-5654720: PI-3K cascade:FGFR4
R-BTA-9027276: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-DRE-8964026: Chylomicron clearance
R-DRE-8964038: LDL clearance
R-XTR-114516: Disinhibition of SNARE formation
R-XTR-399997: Acetylcholine regulates insulin secretion
R-XTR-4419969: Depolymerisation of the Nuclear Lamina
R-XTR-76005: Response to elevated platelet cytosolic Ca2+
R-CFA-5620916: VxPx cargo-targeting to cilium
R-HSA-140834: Extrinsic Pathway of Fibrin Clot Formation
R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation
R-XTR-199418: Negative regulation of the PI3K/AKT network
R-XTR-202424: Downstream TCR signaling
R-XTR-5689896: Ovarian tumor domain proteases
R-DME-1660661: Sphingolipid de novo biosynthesis
R-HSA-8948751: Regulation of PTEN stability and activity
R-BTA-1912408: Pre-NOTCH Transcription and Translation
R-BTA-209543: p75NTR recruits signalling complexes
R-BTA-420029: Tight junction interactions
R-XTR-432720: Lysosome Vesicle Biogenesis
R-RNO-140834: Extrinsic Pathway of Fibrin Clot Formation
R-SSC-168138: Toll Like Receptor 9 (TLR9) Cascade
R-RNO-5627123: RHO GTPases activate PAKs
R-GGA-2173789: TGF-beta receptor signaling activates SMADs
R-DRE-112399: IRS-mediated signalling
R-DRE-1266695: Interleukin-7 signaling
R-DRE-198203: PI3K/AKT activation
R-DRE-2428928: IRS-related events triggered by IGF1R
R-DRE-74713: IRS activation
R-CFA-1474228: Degradation of the extracellular matrix
R-DRE-5173214: O-glycosylation of TSR domain-containing proteins
R-DRE-5620916: VxPx cargo-targeting to cilium
R-CFA-165158: Activation of AKT2
R-CFA-165181: Inhibition of TSC complex formation by PKB
R-CFA-3769402: Deactivation of the beta-catenin transactivating complex
R-MMU-445095: Interaction between L1 and Ankyrins
R-MMU-6807878: COPI-mediated anterograde transport
R-BTA-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-BTA-3299685: Detoxification of Reactive Oxygen Species
R-BTA-5668599: RHO GTPases Activate NADPH Oxidases
R-SSC-418594: G alpha (i) signalling events
R-BTA-446353: Cell-extracellular matrix interactions
R-DRE-6804757: Regulation of TP53 Degradation
R-HSA-8940973: RUNX2 regulates osteoblast differentiation
R-XTR-165158: Activation of AKT2
R-XTR-165181: Inhibition of TSC complex formation by PKB
R-XTR-3769402: Deactivation of the beta-catenin transactivating complex
R-DME-1253288: Downregulation of ERBB4 signaling
R-DME-2122948: Activated NOTCH1 Transmits Signal to the Nucleus
R-DME-5610780: Degradation of GLI1 by the proteasome
R-DME-5632684: Hedgehog 'on' state
R-DME-1660516: Synthesis of PIPs at the early endosome membrane
R-XTR-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-XTR-4086398: Ca2+ pathway
R-XTR-418217: G beta:gamma signalling through PLC beta
R-XTR-500657: Presynaptic function of Kainate receptors
R-XTR-9020702: Interleukin-1 signaling
R-CEL-6811440: Retrograde transport at the Trans-Golgi-Network
R-XTR-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-XTR-445355: Smooth Muscle Contraction
R-DRE-8941237: Invadopodia formation
R-SSC-3928663: EPHA-mediated growth cone collapse
R-HSA-399719: Trafficking of AMPA receptors
R-XTR-430116: GP1b-IX-V activation signalling
R-XTR-5621575: CD209 (DC-SIGN) signaling
R-DRE-74749: Signal attenuation
R-DRE-74751: Insulin receptor signalling cascade
R-MMU-1483248: Synthesis of PIPs at the ER membrane
R-MMU-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-204005: COPII-mediated vesicle transport
R-HSA-5694530: Cargo concentration in the ER
R-RNO-111465: Apoptotic cleavage of cellular proteins
R-RNO-1489509: DAG and IP3 signaling
R-RNO-877300: Interferon gamma signaling
R-MMU-5620916: VxPx cargo-targeting to cilium
R-DRE-8866427: VLDLR internalisation and degradation
R-RNO-1169092: Activation of RAS in B cells
R-BTA-1632852: Macroautophagy
R-HSA-5625900: RHO GTPases activate CIT
R-RNO-8941237: Invadopodia formation
R-RNO-4641258: Degradation of DVL
R-SSC-375276: Peptide ligand-binding receptors
R-SSC-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-SSC-76009: Platelet Aggregation (Plug Formation)
R-DRE-1660662: Glycosphingolipid metabolism
R-GGA-9020702: Interleukin-1 signaling
R-DME-109704: PI3K Cascade
R-DME-112399: IRS-mediated signalling
R-DME-114604: GPVI-mediated activation cascade
R-DME-1257604: PIP3 activates AKT signaling
R-DME-198203: PI3K/AKT activation
R-DME-210993: Tie2 Signaling
R-DME-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-912631: Regulation of signaling by CBL
R-DME-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-DRE-210993: Tie2 Signaling
R-HSA-445355: Smooth Muscle Contraction
R-GGA-432720: Lysosome Vesicle Biogenesis
R-MMU-416572: Sema4D induced cell migration and growth-cone collapse
R-SSC-180292: GAB1 signalosome
R-SSC-1963642: PI3K events in ERBB2 signaling
R-SSC-5654689: PI-3K cascade:FGFR1
R-SSC-5654695: PI-3K cascade:FGFR2
R-SSC-5654710: PI-3K cascade:FGFR3
R-SSC-5654720: PI-3K cascade:FGFR4
R-SSC-8851907: MET activates PI3K/AKT signaling
R-SSC-8865999: MET activates PTPN11
R-SSC-8875555: MET activates RAP1 and RAC1
R-SSC-8875656: MET receptor recycling
R-SSC-9027276: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-BTA-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-8854214: TBC/RABGAPs
R-CFA-5173214: O-glycosylation of TSR domain-containing proteins
R-GGA-2871837: FCERI mediated NF-kB activation
R-GGA-373752: Netrin-1 signaling
R-CEL-1257604: PIP3 activates AKT signaling
R-CEL-165158: Activation of AKT2
R-CEL-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-CEL-389357: CD28 dependent PI3K/Akt signaling
R-CEL-392451: G beta:gamma signalling through PI3Kgamma
R-CEL-5625740: RHO GTPases activate PKNs
R-CEL-114608: Platelet degranulation
R-CEL-445355: Smooth Muscle Contraction
R-DRE-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-8951664: Neddylation
R-MMU-75205: Dissolution of Fibrin Clot
R-RNO-210993: Tie2 Signaling
R-DME-1660514: Synthesis of PIPs at the Golgi membrane
R-RNO-1912408: Pre-NOTCH Transcription and Translation
R-RNO-209543: p75NTR recruits signalling complexes
R-RNO-420029: Tight junction interactions
R-SPO-1660514: Synthesis of PIPs at the Golgi membrane
R-SPO-1660516: Synthesis of PIPs at the early endosome membrane
R-SPO-1660517: Synthesis of PIPs at the late endosome membrane
R-BTA-391160: Signal regulatory protein family interactions
R-XTR-2871837: FCERI mediated NF-kB activation
R-MMU-8964026: Chylomicron clearance
R-MMU-8964038: LDL clearance
R-CEL-8951664: Neddylation
R-SSC-112399: IRS-mediated signalling
R-SSC-1266695: Interleukin-7 signaling
R-SSC-198203: PI3K/AKT activation
R-SSC-2428928: IRS-related events triggered by IGF1R
R-CEL-198323: AKT phosphorylates targets in the cytosol
R-CEL-198693: AKT phosphorylates targets in the nucleus
R-CEL-199418: Negative regulation of the PI3K/AKT network
R-CEL-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-CEL-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-1632852: Macroautophagy
R-DME-2173788: Downregulation of TGF-beta receptor signaling
R-DME-2028269: Signaling by Hippo
R-BTA-5658442: Regulation of RAS by GAPs
R-RNO-8983432: Interleukin-15 signaling
R-HSA-1433559: Regulation of KIT signaling
R-BTA-8964038: LDL clearance
R-HSA-8951664: Neddylation
R-DRE-1433557: Signaling by SCF-KIT
R-RNO-1482788: Acyl chain remodelling of PC
R-RNO-1482801: Acyl chain remodelling of PS
R-RNO-1482839: Acyl chain remodelling of PE
R-RNO-1482922: Acyl chain remodelling of PI
R-RNO-1482925: Acyl chain remodelling of PG
R-RNO-1483115: Hydrolysis of LPC
R-GGA-3928664: Ephrin signaling
R-GGA-5620916: VxPx cargo-targeting to cilium
R-CFA-3238698: WNT ligand biogenesis and trafficking
R-XTR-203641: NOSTRIN mediated eNOS trafficking
R-DME-190873: Gap junction degradation
R-DME-196025: Formation of annular gap junctions
R-DME-203641: NOSTRIN mediated eNOS trafficking
R-DME-437239: Recycling pathway of L1
R-SPO-1483166: Synthesis of PA
R-SPO-2029485: Role of phospholipids in phagocytosis
R-SPO-6798695: Neutrophil degranulation
R-DRE-114516: Disinhibition of SNARE formation
R-DRE-1169091: Activation of NF-kappaB in B cells
R-DRE-4419969: Depolymerisation of the Nuclear Lamina
R-DRE-5099900: WNT5A-dependent internalization of FZD4
R-DRE-76005: Response to elevated platelet cytosolic Ca2+
R-CEL-1912408: Pre-NOTCH Transcription and Translation
R-GGA-6807004: Negative regulation of MET activity
R-GGA-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-CFA-3928663: EPHA-mediated growth cone collapse
R-DRE-1253288: Downregulation of ERBB4 signaling
R-HSA-5620924: Intraflagellar transport
R-SSC-177504: Retrograde neurotrophin signalling
R-HSA-1632852: Macroautophagy
R-HSA-5668599: RHO GTPases Activate NADPH Oxidases
R-BTA-2173789: TGF-beta receptor signaling activates SMADs
R-CFA-140834: Extrinsic Pathway of Fibrin Clot Formation
R-CFA-1170546: Prolactin receptor signaling
R-CFA-982772: Growth hormone receptor signaling
R-RNO-202424: Downstream TCR signaling
R-RNO-5689880: Ub-specific processing proteases
R-RNO-5689896: Ovarian tumor domain proteases
R-SPO-1632852: Macroautophagy
R-SPO-5668599: RHO GTPases Activate NADPH Oxidases
R-HSA-1250196: SHC1 events in ERBB2 signaling
R-HSA-1489509: DAG and IP3 signaling
R-HSA-2029485: Role of phospholipids in phagocytosis
R-HSA-418597: G alpha (z) signalling events
R-SSC-8951664: Neddylation
R-HSA-5610787: Hedgehog 'off' state
R-DRE-8876198: RAB GEFs exchange GTP for GDP on RABs
R-BTA-75205: Dissolution of Fibrin Clot
R-BTA-2173788: Downregulation of TGF-beta receptor signaling
R-BTA-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-BTA-4608870: Asymmetric localization of PCP proteins
R-BTA-4641257: Degradation of AXIN
R-BTA-5632684: Hedgehog 'on' state
R-BTA-8941858: Regulation of RUNX3 expression and activity
R-CFA-112399: IRS-mediated signalling
R-CFA-112412: SOS-mediated signalling
R-CFA-1266695: Interleukin-7 signaling
R-CFA-198203: PI3K/AKT activation
R-CFA-2428928: IRS-related events triggered by IGF1R
R-CFA-74749: Signal attenuation
R-CFA-1250347: SHC1 events in ERBB4 signaling
R-CFA-167044: Signalling to RAS
R-CFA-179812: GRB2 events in EGFR signaling
R-CFA-180336: SHC1 events in EGFR signaling
R-CFA-1963640: GRB2 events in ERBB2 signaling
R-CFA-2179392: EGFR Transactivation by Gastrin
R-CFA-2428933: SHC-related events triggered by IGF1R
R-CFA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-CFA-5654688: SHC-mediated cascade:FGFR1
R-CFA-5654693: FRS-mediated FGFR1 signaling
R-CFA-5654699: SHC-mediated cascade:FGFR2
R-CFA-5654700: FRS-mediated FGFR2 signaling
R-CFA-5654704: SHC-mediated cascade:FGFR3
R-CFA-5654706: FRS-mediated FGFR3 signaling
R-CFA-5654712: FRS-mediated FGFR4 signaling
R-CFA-5654719: SHC-mediated cascade:FGFR4
R-CFA-74751: Insulin receptor signalling cascade
R-CFA-8851805: MET activates RAS signaling
R-CFA-9028731: Activated NTRK2 signals through FRS2 and FRS3
R-CFA-912526: Interleukin receptor SHC signaling
R-XTR-5625900: RHO GTPases activate CIT
R-MMU-204005: COPII-mediated vesicle transport
R-MMU-5694530: Cargo concentration in the ER
R-RNO-375276: Peptide ligand-binding receptors
R-RNO-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-RNO-76009: Platelet Aggregation (Plug Formation)
R-RNO-977606: Regulation of Complement cascade
R-GGA-5610780: Degradation of GLI1 by the proteasome
R-XTR-112399: IRS-mediated signalling
R-XTR-1257604: PIP3 activates AKT signaling
R-XTR-198203: PI3K/AKT activation
R-XTR-2428928: IRS-related events triggered by IGF1R
R-XTR-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SSC-5620924: Intraflagellar transport
R-DRE-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-DRE-445355: Smooth Muscle Contraction
R-DRE-112043: PLC beta mediated events
R-DRE-399997: Acetylcholine regulates insulin secretion
R-DRE-4086398: Ca2+ pathway
R-DRE-418217: G beta:gamma signalling through PLC beta
R-DRE-434316: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-DRE-500657: Presynaptic function of Kainate receptors
R-CEL-1483248: Synthesis of PIPs at the ER membrane
R-CEL-8876198: RAB GEFs exchange GTP for GDP on RABs
R-DDI-114604: GPVI-mediated activation cascade
R-DDI-1257604: PIP3 activates AKT signaling
R-DDI-165158: Activation of AKT2
R-DDI-202424: Downstream TCR signaling
R-DDI-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-DDI-389357: CD28 dependent PI3K/Akt signaling
R-DDI-392451: G beta:gamma signalling through PI3Kgamma
R-DDI-5218920: VEGFR2 mediated vascular permeability
R-DDI-5218921: VEGFR2 mediated cell proliferation
R-DDI-5625740: RHO GTPases activate PKNs
R-DRE-5625900: RHO GTPases activate CIT
R-DME-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-DME-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-DME-4608870: Asymmetric localization of PCP proteins
R-DME-4641257: Degradation of AXIN
R-DME-8941858: Regulation of RUNX3 expression and activity
R-XTR-1474228: Degradation of the extracellular matrix
R-HSA-5655302: Signaling by FGFR1 in disease
R-MMU-8854214: TBC/RABGAPs
R-CFA-5625900: RHO GTPases activate CIT
R-HSA-2871837: FCERI mediated NF-kB activation
R-HSA-5673001: RAF/MAP kinase cascade
R-GGA-193634: Axonal growth inhibition (RHOA activation)
R-CFA-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-CFA-3299685: Detoxification of Reactive Oxygen Species
R-MMU-1483206: Glycerophospholipid biosynthesis
R-HSA-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-HSA-8964616: G beta:gamma signalling through CDC42
R-BTA-4641258: Degradation of DVL
R-XTR-204005: COPII-mediated vesicle transport
R-XTR-5694530: Cargo concentration in the ER
R-SSC-5625740: RHO GTPases activate PKNs
R-SSC-430116: GP1b-IX-V activation signalling
R-SSC-5621575: CD209 (DC-SIGN) signaling
R-GGA-111995: phospho-PLA2 pathway
R-GGA-1482798: Acyl chain remodeling of CL
R-GGA-2142753: Arachidonic acid metabolism
R-GGA-418592: ADP signalling through P2Y purinoceptor 1
R-GGA-432142: Platelet sensitization by LDL
R-GGA-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-HSA-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-MMU-418555: G alpha (s) signalling events
R-DRE-194306: Neurophilin interactions with VEGF and VEGFR
R-DRE-399954: Sema3A PAK dependent Axon repulsion
R-DRE-399956: CRMPs in Sema3A signaling
R-DRE-445144: Signal transduction by L1
R-BTA-5620916: VxPx cargo-targeting to cilium
R-DRE-1483206: Glycerophospholipid biosynthesis
R-GGA-181430: Norepinephrine Neurotransmitter Release Cycle
R-GGA-264642: Acetylcholine Neurotransmitter Release Cycle
R-GGA-888590: GABA synthesis, release, reuptake and degradation
R-DRE-193634: Axonal growth inhibition (RHOA activation)
R-DRE-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-MMU-166016: Toll Like Receptor 4 (TLR4) Cascade
R-MMU-190873: Gap junction degradation
R-MMU-196025: Formation of annular gap junctions
R-MMU-2132295: MHC class II antigen presentation
R-MMU-437239: Recycling pathway of L1
R-HSA-5658442: Regulation of RAS by GAPs
R-CFA-444473: Formyl peptide receptors bind formyl peptides and many other ligands
R-DME-1855183: Synthesis of IP2, IP, and Ins in the cytosol
R-BTA-203641: NOSTRIN mediated eNOS trafficking
R-BTA-432720: Lysosome Vesicle Biogenesis
R-CEL-1169408: ISG15 antiviral mechanism
R-DRE-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-DRE-3299685: Detoxification of Reactive Oxygen Species
R-SSC-6807878: COPI-mediated anterograde transport
R-CEL-1483166: Synthesis of PA
R-BTA-418594: G alpha (i) signalling events
R-DRE-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-HSA-418885: DCC mediated attractive signaling
R-DME-1433557: Signaling by SCF-KIT
R-DME-2871796: FCERI mediated MAPK activation
R-DME-5218920: VEGFR2 mediated vascular permeability
R-SSC-1306955: GRB7 events in ERBB2 signaling
R-GGA-75205: Dissolution of Fibrin Clot
R-HSA-201451: Signaling by BMP
R-HSA-2173788: Downregulation of TGF-beta receptor signaling
R-HSA-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-4608870: Asymmetric localization of PCP proteins
R-HSA-4641257: Degradation of AXIN
R-HSA-5632684: Hedgehog 'on' state
R-HSA-5689880: Ub-specific processing proteases
R-HSA-8941858: Regulation of RUNX3 expression and activity
R-BTA-6811438: Intra-Golgi traffic
R-HSA-5687128: MAPK6/MAPK4 signaling
R-XTR-1483206: Glycerophospholipid biosynthesis
R-CFA-8941237: Invadopodia formation
R-SPO-192105: Synthesis of bile acids and bile salts
R-RNO-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-DRE-418555: G alpha (s) signalling events
R-XTR-8849474: PTK6 Activates STAT3
R-DME-202433: Generation of second messenger molecules
R-DME-5654219: Phospholipase C-mediated cascade: FGFR1
R-DME-5654221: Phospholipase C-mediated cascade; FGFR2
R-DME-5654227: Phospholipase C-mediated cascade; FGFR3
R-DME-5654228: Phospholipase C-mediated cascade; FGFR4
R-DDI-114608: Platelet degranulation
R-XTR-210990: PECAM1 interactions
R-XTR-212718: EGFR interacts with phospholipase C-gamma
R-XTR-5654219: Phospholipase C-mediated cascade: FGFR1
R-XTR-5654221: Phospholipase C-mediated cascade; FGFR2
R-XTR-5654227: Phospholipase C-mediated cascade; FGFR3
R-XTR-5654228: Phospholipase C-mediated cascade; FGFR4
R-XTR-9026527: Activated NTRK2 signals through PLCG1
R-XTR-9034793: Activated NTRK3 signals through PLCG1
R-SSC-3238698: WNT ligand biogenesis and trafficking
R-RNO-1250347: SHC1 events in ERBB4 signaling
R-RNO-167044: Signalling to RAS
R-RNO-179812: GRB2 events in EGFR signaling
R-RNO-180336: SHC1 events in EGFR signaling
R-RNO-186763: Downstream signal transduction
R-RNO-1963640: GRB2 events in ERBB2 signaling
R-RNO-2428933: SHC-related events triggered by IGF1R
R-RNO-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-RNO-375165: NCAM signaling for neurite out-growth
R-RNO-5654688: SHC-mediated cascade:FGFR1
R-RNO-5654693: FRS-mediated FGFR1 signaling
R-RNO-5654699: SHC-mediated cascade:FGFR2
R-RNO-5654700: FRS-mediated FGFR2 signaling
R-RNO-5654704: SHC-mediated cascade:FGFR3
R-RNO-5654706: FRS-mediated FGFR3 signaling
R-RNO-5654712: FRS-mediated FGFR4 signaling
R-RNO-5654719: SHC-mediated cascade:FGFR4
R-RNO-8851805: MET activates RAS signaling
R-RNO-9028731: Activated NTRK2 signals through FRS2 and FRS3
R-RNO-912526: Interleukin receptor SHC signaling
R-MMU-111465: Apoptotic cleavage of cellular proteins
R-XTR-8941237: Invadopodia formation
R-CFA-203641: NOSTRIN mediated eNOS trafficking
R-BTA-1483206: Glycerophospholipid biosynthesis
R-RNO-212718: EGFR interacts with phospholipase C-gamma
R-RNO-5654219: Phospholipase C-mediated cascade: FGFR1
R-RNO-5654221: Phospholipase C-mediated cascade; FGFR2
R-RNO-5654227: Phospholipase C-mediated cascade; FGFR3
R-RNO-5654228: Phospholipase C-mediated cascade; FGFR4
R-RNO-9026527: Activated NTRK2 signals through PLCG1
R-RNO-9034793: Activated NTRK3 signals through PLCG1
R-DRE-1169092: Activation of RAS in B cells
R-HSA-977443: GABA receptor activation
R-DME-168138: Toll Like Receptor 9 (TLR9) Cascade
R-DME-5668599: RHO GTPases Activate NADPH Oxidases
R-DRE-380270: Recruitment of mitotic centrosome proteins and complexes
R-DRE-380320: Recruitment of NuMA to mitotic centrosomes
R-XTR-8866427: VLDLR internalisation and degradation
R-HSA-8875513: MET interacts with TNS proteins
R-XTR-3928663: EPHA-mediated growth cone collapse
R-SSC-204005: COPII-mediated vesicle transport
R-SSC-5694530: Cargo concentration in the ER
R-DRE-1855183: Synthesis of IP2, IP, and Ins in the cytosol
R-XTR-1483248: Synthesis of PIPs at the ER membrane
R-MMU-111933: Calmodulin induced events
R-MMU-5635838: Activation of SMO
R-DRE-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-DRE-8964616: G beta:gamma signalling through CDC42
R-GGA-1306955: GRB7 events in ERBB2 signaling
R-HSA-1483148: Synthesis of PG
R-HSA-1483166: Synthesis of PA
R-CFA-8964038: LDL clearance
R-HSA-1660661: Sphingolipid de novo biosynthesis
R-XTR-389357: CD28 dependent PI3K/Akt signaling
R-XTR-5625740: RHO GTPases activate PKNs
R-XTR-180292: GAB1 signalosome
R-XTR-1963642: PI3K events in ERBB2 signaling
R-XTR-5654689: PI-3K cascade:FGFR1
R-XTR-5654695: PI-3K cascade:FGFR2
R-XTR-5654710: PI-3K cascade:FGFR3
R-XTR-5654720: PI-3K cascade:FGFR4
R-XTR-8851907: MET activates PI3K/AKT signaling
R-XTR-8865999: MET activates PTPN11
R-XTR-8875555: MET activates RAP1 and RAC1
R-XTR-8875656: MET receptor recycling
R-XTR-9027276: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-RNO-2028269: Signaling by Hippo
R-XTR-264642: Acetylcholine Neurotransmitter Release Cycle
R-MMU-418885: DCC mediated attractive signaling
R-DME-3238698: WNT ligand biogenesis and trafficking
R-DRE-4608870: Asymmetric localization of PCP proteins
R-DRE-8941858: Regulation of RUNX3 expression and activity
R-GGA-6807878: COPI-mediated anterograde transport
R-HSA-391160: Signal regulatory protein family interactions
R-DRE-1433559: Regulation of KIT signaling
R-DRE-5626978: TNFR1-mediated ceramide production
R-BTA-8964315: G beta:gamma signalling through BTK
R-DRE-2173788: Downregulation of TGF-beta receptor signaling
R-DRE-4641257: Degradation of AXIN
R-CFA-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-CFA-877300: Interferon gamma signaling
R-HSA-1169092: Activation of RAS in B cells
R-CEL-430116: GP1b-IX-V activation signalling
R-CEL-5621575: CD209 (DC-SIGN) signaling
R-CEL-5673000: RAF activation
R-CEL-5674135: MAP2K and MAPK activation
R-CEL-5674499: Negative feedback regulation of MAPK pathway
R-CEL-5675221: Negative regulation of MAPK pathway
R-RNO-3928663: EPHA-mediated growth cone collapse
R-RNO-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-RNO-165159: mTOR signalling
R-RNO-203615: eNOS activation
R-RNO-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-211728: Regulation of PAK-2p34 activity by PS-GAP/RHG10
R-GGA-512988: Interleukin-3, Interleukin-5 and GM-CSF signaling
R-GGA-912631: Regulation of signaling by CBL
R-MMU-5173214: O-glycosylation of TSR domain-containing proteins
R-GGA-1474228: Degradation of the extracellular matrix
R-CFA-5625740: RHO GTPases activate PKNs
R-DME-112412: SOS-mediated signalling
R-DME-1250347: SHC1 events in ERBB4 signaling
R-DME-167044: Signalling to RAS
R-DME-179812: GRB2 events in EGFR signaling
R-DME-180336: SHC1 events in EGFR signaling
R-DME-1963640: GRB2 events in ERBB2 signaling
R-DME-2179392: EGFR Transactivation by Gastrin
R-DME-2428933: SHC-related events triggered by IGF1R
R-DME-375165: NCAM signaling for neurite out-growth
R-DME-5654688: SHC-mediated cascade:FGFR1
R-DME-5654693: FRS-mediated FGFR1 signaling
R-DME-5654699: SHC-mediated cascade:FGFR2
R-DME-5654700: FRS-mediated FGFR2 signaling
R-DME-5654704: SHC-mediated cascade:FGFR3
R-DME-5654706: FRS-mediated FGFR3 signaling
R-DME-5654712: FRS-mediated FGFR4 signaling
R-DME-5654719: SHC-mediated cascade:FGFR4
R-DME-5673001: RAF/MAP kinase cascade
R-DME-74749: Signal attenuation
R-DME-74751: Insulin receptor signalling cascade
R-DRE-2179392: EGFR Transactivation by Gastrin
R-DRE-3000170: Syndecan interactions
R-HSA-112412: SOS-mediated signalling
R-HSA-1236382: Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250347: SHC1 events in ERBB4 signaling
R-HSA-167044: Signalling to RAS
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-186763: Downstream signal transduction
R-HSA-1963640: GRB2 events in ERBB2 signaling
R-HSA-210993: Tie2 Signaling
R-HSA-2179392: EGFR Transactivation by Gastrin
R-HSA-2424491: DAP12 signaling
R-HSA-2428933: SHC-related events triggered by IGF1R
R-HSA-354194: GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-5637810: Constitutive Signaling by EGFRvIII
R-HSA-5654688: SHC-mediated cascade:FGFR1
R-HSA-5654693: FRS-mediated FGFR1 signaling
R-HSA-5654699: SHC-mediated cascade:FGFR2
R-HSA-5654700: FRS-mediated FGFR2 signaling
R-HSA-5654704: SHC-mediated cascade:FGFR3
R-HSA-5654706: FRS-mediated FGFR3 signaling
R-HSA-5654712: FRS-mediated FGFR4 signaling
R-HSA-5654719: SHC-mediated cascade:FGFR4
R-HSA-5655253: Signaling by FGFR2 in disease
R-HSA-5655291: Signaling by FGFR4 in disease
R-HSA-74749: Signal attenuation
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-8851805: MET activates RAS signaling
R-HSA-8853334: Signaling by FGFR3 fusions in cancer
R-HSA-8853338: Signaling by FGFR3 point mutants in cancer
R-HSA-9026519: Activated NTRK2 signals through RAS
R-HSA-9028731: Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9034864: Activated NTRK3 signals through RAS
R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275: Post-translational protein phosphorylation
R-BTA-9020558: Interleukin-2 signaling
R-HSA-442982: Ras activation upon Ca2+ influx through NMDA receptor
R-MMU-202433: Generation of second messenger molecules
R-BTA-177504: Retrograde neurotrophin signalling
R-XTR-177504: Retrograde neurotrophin signalling
R-MMU-1660514: Synthesis of PIPs at the Golgi membrane
R-MMU-1660516: Synthesis of PIPs at the early endosome membrane
R-RNO-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-SSC-1660662: Glycosphingolipid metabolism
R-XTR-888590: GABA synthesis, release, reuptake and degradation
R-RNO-391160: Signal regulatory protein family interactions
R-BTA-8854214: TBC/RABGAPs
R-BTA-5610787: Hedgehog 'off' state
R-DME-1295596: Spry regulation of FGF signaling
R-DME-392517: Rap1 signalling
R-DME-430116: GP1b-IX-V activation signalling
R-DME-5621575: CD209 (DC-SIGN) signaling
R-DME-5673000: RAF activation
R-DME-5674499: Negative feedback regulation of MAPK pathway
R-DME-5675221: Negative regulation of MAPK pathway
R-CFA-193634: Axonal growth inhibition (RHOA activation)
R-HSA-264876: Insulin processing
R-DME-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-165158: Activation of AKT2
R-DME-165159: mTOR signalling
R-DME-165181: Inhibition of TSC complex formation by PKB
R-DME-198323: AKT phosphorylates targets in the cytosol
R-DME-198693: AKT phosphorylates targets in the nucleus
R-DME-203615: eNOS activation
R-DME-389357: CD28 dependent PI3K/Akt signaling
R-DME-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-DME-5628897: TP53 Regulates Metabolic Genes
R-RNO-1632852: Macroautophagy
R-DRE-9020702: Interleukin-1 signaling
R-BTA-2871837: FCERI mediated NF-kB activation
R-BTA-373752: Netrin-1 signaling
R-BTA-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-RNO-418889: Caspase activation via Dependence Receptors in the absence of ligand
R-SSC-8964038: LDL clearance
R-GGA-8941237: Invadopodia formation
R-DRE-1306955: GRB7 events in ERBB2 signaling
R-CFA-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-CFA-165159: mTOR signalling
R-CFA-203615: eNOS activation
R-CFA-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-MMU-8951664: Neddylation
R-DRE-8964315: G beta:gamma signalling through BTK
R-CFA-2173795: Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-RNO-5635838: Activation of SMO
R-MMU-5626978: TNFR1-mediated ceramide production
R-MMU-5668599: RHO GTPases Activate NADPH Oxidases
R-MMU-1169408: ISG15 antiviral mechanism
R-MMU-210990: PECAM1 interactions
R-MMU-212718: EGFR interacts with phospholipase C-gamma
R-MMU-5218921: VEGFR2 mediated cell proliferation
R-MMU-5654219: Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221: Phospholipase C-mediated cascade; FGFR2
R-MMU-5654227: Phospholipase C-mediated cascade; FGFR3
R-MMU-5654228: Phospholipase C-mediated cascade; FGFR4
R-MMU-9026527: Activated NTRK2 signals through PLCG1
R-MMU-9034793: Activated NTRK3 signals through PLCG1
R-MMU-9020702: Interleukin-1 signaling
R-MMU-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-1250196: SHC1 events in ERBB2 signaling
R-MMU-1489509: DAG and IP3 signaling
R-MMU-5607764: CLEC7A (Dectin-1) signaling
R-RNO-8964026: Chylomicron clearance
R-RNO-8964038: LDL clearance
R-RNO-1170546: Prolactin receptor signaling
R-RNO-982772: Growth hormone receptor signaling
R-SCE-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-DME-451806: Phosphorylation-independent inhibition of YKI
R-DME-1169408: ISG15 antiviral mechanism
R-HSA-1169408: ISG15 antiviral mechanism
R-HSA-1251932: PLCG1 events in ERBB2 signaling
R-HSA-167021: PLC-gamma1 signalling
R-HSA-202433: Generation of second messenger molecules
R-HSA-210990: PECAM1 interactions
R-HSA-212718: EGFR interacts with phospholipase C-gamma
R-HSA-418890: Role of second messengers in netrin-1 signaling
R-HSA-5218921: VEGFR2 mediated cell proliferation
R-HSA-5654219: Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221: Phospholipase C-mediated cascade; FGFR2
R-HSA-5654227: Phospholipase C-mediated cascade; FGFR3
R-HSA-5654228: Phospholipase C-mediated cascade; FGFR4
R-HSA-9026527: Activated NTRK2 signals through PLCG1
R-HSA-9027277: Erythropoietin activates Phospholipase C gamma (PLCG)
R-HSA-9034793: Activated NTRK3 signals through PLCG1
R-HSA-392517: Rap1 signalling
R-HSA-430116: GP1b-IX-V activation signalling
R-HSA-5621575: CD209 (DC-SIGN) signaling
R-HSA-5607764: CLEC7A (Dectin-1) signaling
R-HSA-5621480: Dectin-2 family
R-HSA-445144: Signal transduction by L1
R-HSA-3238698: WNT ligand biogenesis and trafficking
R-HSA-2173789: TGF-beta receptor signaling activates SMADs
R-HSA-3304356: SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-3315487: SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-3656532: TGFBR1 KD Mutants in Cancer
R-HSA-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-HSA-180292: GAB1 signalosome
R-HSA-1963642: PI3K events in ERBB2 signaling
R-HSA-5654689: PI-3K cascade:FGFR1
R-HSA-5654695: PI-3K cascade:FGFR2
R-HSA-5654710: PI-3K cascade:FGFR3
R-HSA-5654720: PI-3K cascade:FGFR4
R-HSA-8851907: MET activates PI3K/AKT signaling
R-HSA-8865999: MET activates PTPN11
R-HSA-8875555: MET activates RAP1 and RAC1
R-HSA-8875656: MET receptor recycling
R-HSA-9027276: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-HSA-9028335: Activated NTRK2 signals through PI3K
R-HSA-112399: IRS-mediated signalling
R-HSA-1266695: Interleukin-7 signaling
R-HSA-198203: PI3K/AKT activation
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-2586552: Signaling by Leptin
R-HSA-74713: IRS activation
R-HSA-9603381: Activated NTRK3 signals through PI3K
R-HSA-982772: Growth hormone receptor signaling
R-HSA-8941237: Invadopodia formation
R-HSA-1170546: Prolactin receptor signaling
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-76009: Platelet Aggregation (Plug Formation)
R-HSA-111447: Activation of BAD and translocation to mitochondria
R-HSA-1358803: Downregulation of ERBB2:ERBB3 signaling
R-HSA-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-165159: mTOR signalling
R-HSA-198323: AKT phosphorylates targets in the cytosol
R-HSA-198693: AKT phosphorylates targets in the nucleus
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-203615: eNOS activation
R-HSA-211163: AKT-mediated inactivation of FOXO1A
R-HSA-354192: Integrin alphaIIb beta3 signaling
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-389357: CD28 dependent PI3K/Akt signaling
R-HSA-389513: CTLA4 inhibitory signaling
R-HSA-392451: G beta:gamma signalling through PI3Kgamma
R-HSA-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450604: KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-5628897: TP53 Regulates Metabolic Genes
R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6785807: Interleukin-4 and Interleukin-13 signaling
R-HSA-6804757: Regulation of TP53 Degradation
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-6804759: Regulation of TP53 Activity through Association with Co-factors
R-HSA-69202: Cyclin E associated events during G1/S transition
R-HSA-69656: Cyclin A:Cdk2-associated events at S phase entry
R-HSA-8941332: RUNX2 regulates genes involved in cell migration
R-HSA-9604323: Negative regulation of NOTCH4 signaling
R-HSA-9614399: Regulation of localization of FOXO transcription factors
R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-75205: Dissolution of Fibrin Clot
R-HSA-8950505: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-111933: Calmodulin induced events
R-HSA-5635838: Activation of SMO
R-HSA-164944: Nef and signal transduction
R-HSA-1368108: BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-162588: Budding and maturation of HIV virion
R-HSA-9008059: Interleukin-37 signaling
R-HSA-202424: Downstream TCR signaling
R-HSA-5674404: PTEN Loss of Function in Cancer
R-HSA-5689896: Ovarian tumor domain proteases
R-HSA-8943723: Regulation of PTEN mRNA translation
R-HSA-8948747: Regulation of PTEN localization
R-HSA-8986944: Transcriptional Regulation by MECP2
R-HSA-6781823: Formation of TC-NER Pre-Incision Complex
R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135: Dual incision in TC-NER
R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-8866652: Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-1268020: Mitochondrial protein import
R-HSA-5205685: Pink/Parkin Mediated Mitophagy
R-HSA-4551638: SUMOylation of chromatin organization proteins
R-HSA-8953750: Transcriptional Regulation by E2F6
R-HSA-389957: Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960: Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450: Folding of actin by CCT/TriC
R-HSA-390471: Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922: BBSome-mediated cargo-targeting to cilium
R-HSA-6814122: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-163125: Post-translational modification: synthesis of GPI-anchored proteins
R-GGA-449836: Other interleukin signaling
R-MMU-140534: Caspase activation via Death Receptors in the presence of ligand
R-MMU-2562578: TRIF-mediated programmed cell death
R-MMU-3295583: TRP channels
R-MMU-3371378: Regulation by c-FLIP
R-MMU-5213460: RIPK1-mediated regulated necrosis
R-MMU-5218900: CASP8 activity is inhibited
R-MMU-5357786: TNFR1-induced proapoptotic signaling
R-MMU-5357905: Regulation of TNFR1 signaling
R-MMU-5357956: TNFR1-induced NFkappaB signaling pathway
R-MMU-69416: Dimerization of procaspase-8
R-MMU-75893: TNF signaling
R-MMU-937041: IKK complex recruitment mediated by RIP1
R-MMU-5358346: Hedgehog ligand biogenesis
R-MMU-5362798: Release of Hh-Np from the secreting cell
R-MMU-5632681: Ligand-receptor interactions
R-HSA-8877627: Vitamin E
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-9022702: MECP2 regulates transcription of neuronal ligands
R-HSA-168928: DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-8983711: OAS antiviral response
R-HSA-918233: TRAF3-dependent IRF activation pathway
R-HSA-933541: TRAF6 mediated IRF7 activation
R-HSA-933542: TRAF6 mediated NF-kB activation
R-HSA-933543: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-936440: Negative regulators of DDX58/IFIH1 signaling
R-MMU-5689603: UCH proteinases
R-HSA-2028269: Signaling by Hippo
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-3214842: HDMs demethylate histones
R-HSA-156827: L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-72649: Translation initiation complex formation
R-HSA-72689: Formation of a pool of free 40S subunits
R-HSA-72695: Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702: Ribosomal scanning and start codon recognition
R-HSA-72706: GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-198203: PI3K/AKT activation
R-SCE-392451: G beta:gamma signalling through PI3Kgamma
R-SCE-5625740: RHO GTPases activate PKNs
R-SCE-6798695: Neutrophil degranulation
R-RNO-3371453: Regulation of HSF1-mediated heat shock response
R-RNO-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-HSA-9033241: Peroxisomal protein import
R-HSA-196807: Nicotinate metabolism
R-HSA-176187: Activation of ATR in response to replication stress
R-HSA-5685938: HDR through Single Strand Annealing (SSA)
R-HSA-5693607: Processing of DNA double-strand break ends
R-HSA-5693616: Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6783310: Fanconi Anemia Pathway
R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-69473: G2/M DNA damage checkpoint
R-HSA-379726: Mitochondrial tRNA aminoacylation
R-HSA-8863795: Downregulation of ERBB2 signaling
R-HSA-611105: Respiratory electron transport
R-HSA-196780: Biotin transport and metabolism
R-HSA-199220: Vitamin B5 (pantothenate) metabolism
R-HSA-425397: Transport of vitamins, nucleosides, and related molecules
R-HSA-6803544: Ion influx/efflux at host-pathogen interface
R-HSA-936837: Ion transport by P-type ATPases
R-HSA-112382: Formation of RNA Pol II elongation complex
R-HSA-113418: Formation of the Early Elongation Complex
R-HSA-167152: Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158: Formation of the HIV-1 Early Elongation Complex
R-HSA-167200: Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238: Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242: Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243: Tat-mediated HIV elongation arrest and recovery
R-HSA-167246: Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287: HIV elongation arrest and recovery
R-HSA-167290: Pausing and recovery of HIV elongation
R-HSA-674695: RNA Polymerase II Pre-transcription Events
R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955: RNA Polymerase II Transcription Elongation
R-HSA-9603505: NTRK3 as a dependence receptor
R-MMU-416993: Trafficking of GluR2-containing AMPA receptors
R-MMU-6811438: Intra-Golgi traffic
R-MMU-6811440: Retrograde transport at the Trans-Golgi-Network
R-HSA-977225: Amyloid fiber formation
R-HSA-5389840: Mitochondrial translation elongation
R-MMU-6785807: Interleukin-4 and Interleukin-13 signaling
R-HSA-1169091: Activation of NF-kappaB in B cells
R-HSA-1810476: RIP-mediated NFkB activation via ZBP1
R-HSA-193692: Regulated proteolysis of p75NTR
R-HSA-209560: NF-kB is activated and signals survival
R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP)
R-HSA-3134963: DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-3214841: PKMTs methylate histone lysines
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
R-HSA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-448706: Interleukin-1 processing
R-HSA-4755510: SUMOylation of immune response proteins
R-HSA-5603029: IkBA variant leads to EDA-ID
R-HSA-5607761: Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5660668: CLEC7A/inflammasome pathway
R-HSA-844456: The NLRP3 inflammasome
R-HSA-210745: Regulation of gene expression in beta cells
R-HSA-383280: Nuclear Receptor transcription pathway
R-HSA-4090294: SUMOylation of intracellular receptors
R-HSA-8866427: VLDLR internalisation and degradation
R-MMU-4086400: PCP/CE pathway
R-HSA-70921: Histidine catabolism
R-HSA-390522: Striated Muscle Contraction
R-HSA-416700: Other semaphorin interactions
R-HSA-6783783: Interleukin-10 signaling
R-HSA-8939246: RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-SCE-2559580: Oxidative Stress Induced Senescence
R-SCE-389357: CD28 dependent PI3K/Akt signaling
R-SCE-5607761: Dectin-1 mediated noncanonical NF-kB signaling
R-SCE-5668541: TNFR2 non-canonical NF-kB pathway
R-SCE-5676590: NIK-->noncanonical NF-kB signaling
R-HSA-6809371: Formation of the cornified envelope
R-HSA-173623: Classical antibody-mediated complement activation
R-HSA-8854691: Interleukin-20 family signaling
R-HSA-1296041: Activation of G protein gated Potassium channels
R-HSA-163359: Glucagon signaling in metabolic regulation
R-HSA-202040: G-protein activation
R-HSA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-381771: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-392170: ADP signalling through P2Y purinoceptor 12
R-HSA-392851: Prostacyclin signalling through prostacyclin receptor
R-HSA-400042: Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-418592: ADP signalling through P2Y purinoceptor 1
R-HSA-418594: G alpha (i) signalling events
R-HSA-420092: Glucagon-type ligand receptors
R-HSA-428930: Thromboxane signalling through TP receptor
R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-8964315: G beta:gamma signalling through BTK
R-HSA-997272: Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
R-HSA-449836: Other interleukin signaling
R-HSA-181429: Serotonin Neurotransmitter Release Cycle
R-HSA-181430: Norepinephrine Neurotransmitter Release Cycle
R-HSA-196108: Pregnenolone biosynthesis
R-HSA-210500: Glutamate Neurotransmitter Release Cycle
R-HSA-212676: Dopamine Neurotransmitter Release Cycle
R-HSA-264642: Acetylcholine Neurotransmitter Release Cycle
R-HSA-196757: Metabolism of folate and pterines
R-HSA-8939211: ESR-mediated signaling
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-201688: WNT mediated activation of DVL
R-HSA-4086400: PCP/CE pathway
R-HSA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5368598: Negative regulation of TCF-dependent signaling by DVL-interacting proteins
R-HSA-5663220: RHO GTPases Activate Formins
R-HSA-112308: Presynaptic depolarization and calcium channel opening
R-HSA-419037: NCAM1 interactions
R-HSA-422356: Regulation of insulin secretion
R-HSA-5576892: Phase 0 - rapid depolarisation
R-HSA-5576893: Phase 2 - plateau phase
R-HSA-5689877: Josephin domain DUBs
R-HSA-381042: PERK regulates gene expression
R-HSA-382556: ABC-family proteins mediated transport
R-HSA-72731: Recycling of eIF2:GDP
R-HSA-1059683: Interleukin-6 signaling
R-HSA-110056: MAPK3 (ERK1) activation
R-HSA-112411: MAPK1 (ERK2) activation
R-HSA-450408: AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-MMU-350054: Notch-HLH transcription pathway
R-MMU-8941856: RUNX3 regulates NOTCH signaling
R-HSA-418457: cGMP effects
R-MMU-194313: VEGF ligand-receptor interactions
R-MMU-195399: VEGF binds to VEGFR leading to receptor dimerization
R-HSA-1234158: Regulation of gene expression by Hypoxia-inducible Factor
R-HSA-1368082: RORA activates gene expression
R-HSA-201722: Formation of the beta-catenin:TCF transactivating complex
R-HSA-210744: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168: Activation of gene expression by SREBF (SREBP)
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3134973: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
R-HSA-3214847: HATs acetylate histones
R-HSA-3371568: Attenuation phase
R-HSA-350054: Notch-HLH transcription pathway
R-HSA-3899300: SUMOylation of transcription cofactors
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253: Circadian Clock
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-6803204: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-8866907: Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-8941856: RUNX3 regulates NOTCH signaling
R-HSA-9013508: NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695: NOTCH4 Intracellular Domain Regulates Transcription
R-HSA-9018519: Estrogen-dependent gene expression
R-HSA-9614657: FOXO-mediated transcription of cell death genes
R-HSA-9617629: Regulation of FOXO transcriptional activity by acetylation
R-SPO-113501: Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-SPO-174411: Polymerase switching on the C-strand of the telomere
R-SPO-174430: Telomere C-strand synthesis initiation
R-SPO-68952: DNA replication initiation
R-SPO-68962: Activation of the pre-replicative complex
R-SPO-69091: Polymerase switching
R-SPO-69166: Removal of the Flap Intermediate
R-SPO-69183: Processive synthesis on the lagging strand
R-SCE-110320: Translesion Synthesis by POLH
R-SCE-3371511: HSF1 activation
R-SCE-5689896: Ovarian tumor domain proteases
R-SCE-8876725: Protein methylation
R-MMU-9020558: Interleukin-2 signaling
R-HSA-912694: Regulation of IFNA signaling
R-MMU-5668541: TNFR2 non-canonical NF-kB pathway
R-MMU-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-MMU-936964: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-MMU-2022090: Assembly of collagen fibrils and other multimeric structures
R-MMU-264870: Caspase-mediated cleavage of cytoskeletal proteins
R-MMU-446107: Type I hemidesmosome assembly
R-SCE-171007: p38MAPK events
R-SCE-5218921: VEGFR2 mediated cell proliferation
R-SCE-5673001: RAF/MAP kinase cascade
R-SCE-5675221: Negative regulation of MAPK pathway
R-HSA-380994: ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381183: ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-168277: Influenza Virus Induced Apoptosis
R-HSA-2129379: Molecules associated with elastic fibres
R-HSA-3000170: Syndecan interactions
R-HSA-3000178: ECM proteoglycans
R-HSA-3642279: TGFBR2 MSI Frameshift Mutants in Cancer
R-HSA-3645790: TGFBR2 Kinase Domain Mutants in Cancer
R-HSA-3656535: TGFBR1 LBD Mutants in Cancer
R-HSA-5689603: UCH proteinases
R-HSA-8941855: RUNX3 regulates CDKN1A transcription
R-HSA-8951936: RUNX3 regulates p14-ARF
R-RNO-6805567: Keratinization
R-RNO-6809371: Formation of the cornified envelope
R-MMU-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-1236974: ER-Phagosome pathway
R-MMU-3000480: Scavenging by Class A Receptors
R-MMU-901042: Calnexin/calreticulin cycle
R-MMU-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-HSA-6805567: Keratinization
R-HSA-8939236: RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-111448: Activation of NOXA and translocation to mitochondria
R-MMU-111453: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-162699: Synthesis of dolichyl-phosphate mannose
R-HSA-4717374: Defective DPM1 causes DPM1-CDG (CDG-1e)
R-HSA-5696395: Formation of Incision Complex in GG-NER
R-HSA-5696400: Dual Incision in GG-NER
R-HSA-1251985: Nuclear signaling by ERBB4
R-HSA-879415: Advanced glycosylation endproduct receptor signaling
R-HSA-1483191: Synthesis of PC
R-HSA-2514853: Condensation of Prometaphase Chromosomes
R-HSA-8934903: Receptor Mediated Mitophagy
R-HSA-8939243: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-MMU-3299685: Detoxification of Reactive Oxygen Species
R-HSA-888590: GABA synthesis, release, reuptake and degradation
R-HSA-3371453: Regulation of HSF1-mediated heat shock response
R-MMU-201681: TCF dependent signaling in response to WNT
R-MMU-5099900: WNT5A-dependent internalization of FZD4
R-MMU-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-429958: mRNA decay by 3' to 5' exoribonuclease
R-HSA-450513: Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-6791226: Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-166208: mTORC1-mediated signalling
R-HSA-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-8943724: Regulation of PTEN gene transcription
R-HSA-8866904: Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259: Loss of Nlp from mitotic centrosomes
R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284: Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320: Recruitment of NuMA to mitotic centrosomes
R-HSA-8854518: AURKA Activation by TPX2
R-HSA-202427: Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430: Translocation of ZAP-70 to Immunological synapse
R-HSA-3214858: RMTs methylate histone arginines
R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-8936459: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-909733: Interferon alpha/beta signaling
R-MMU-1059683: Interleukin-6 signaling
R-MMU-877300: Interferon gamma signaling
R-MMU-877312: Regulation of IFNG signaling
R-MMU-8849474: PTK6 Activates STAT3
R-MMU-909733: Interferon alpha/beta signaling
R-HSA-5357905: Regulation of TNFR1 signaling
R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway
R-HSA-8939902: Regulation of RUNX2 expression and activity
R-GGA-204174: Regulation of pyruvate dehydrogenase (PDH) complex
R-GGA-5362517: Signaling by Retinoic Acid
R-HSA-168638: NOD1/2 Signaling Pathway
R-MMU-1251985: Nuclear signaling by ERBB4
R-MMU-2586552: Signaling by Leptin
R-MMU-8854691: Interleukin-20 family signaling
R-MMU-8985947: Interleukin-9 signaling
R-MMU-9020958: Interleukin-21 signaling
R-HSA-380108: Chemokine receptors bind chemokines
R-HSA-141444: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-165054: Rev-mediated nuclear export of HIV RNA
R-HSA-168333: NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-2467813: Separation of Sister Chromatids
R-HSA-2500257: Resolution of Sister Chromatid Cohesion
R-HSA-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-68877: Mitotic Prometaphase
R-HSA-69273: Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-140534: Caspase activation via Death Receptors in the presence of ligand
R-HSA-166166: MyD88-independent TLR4 cascade
R-HSA-2562578: TRIF-mediated programmed cell death
R-HSA-936964: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-937041: IKK complex recruitment mediated by RIP1
R-HSA-937072: TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-MMU-5625970: RHO GTPases activate KTN1
R-HSA-159418: Recycling of bile acids and salts
R-HSA-2168880: Scavenging of heme from plasma
R-HSA-5619058: Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5619110: Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518: Transport of organic anions
R-HSA-8964058: HDL remodeling
R-HSA-8877330: RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558: Interleukin-2 signaling
R-CEL-5620924: Intraflagellar transport
R-CEL-6807878: COPI-mediated anterograde transport
R-CEL-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-HSA-1236974: ER-Phagosome pathway
R-HSA-901042: Calnexin/calreticulin cycle
R-HSA-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-MMU-3214858: RMTs methylate histone arginines
R-MMU-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-8939243: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-1442490: Collagen degradation
R-HSA-2022377: Metabolism of Angiotensinogen to Angiotensins
R-HSA-110320: Translesion Synthesis by POLH
R-DRE-190375: FGFR2c ligand binding and activation
R-DRE-190377: FGFR2b ligand binding and activation
R-DRE-5654699: SHC-mediated cascade:FGFR2
R-DRE-5654700: FRS-mediated FGFR2 signaling
R-DRE-5654727: Negative regulation of FGFR2 signaling
R-MMU-174084: Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-68827: CDT1 association with the CDC6:ORC:origin complex
R-HSA-389948: PD-1 signaling
R-MMU-449836: Other interleukin signaling
R-HSA-186797: Signaling by PDGF
R-HSA-8854214: TBC/RABGAPs
R-HSA-8873719: RAB geranylgeranylation
R-HSA-264870: Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-170670: Adenylate cyclase inhibitory pathway
R-HSA-166058: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-450302: activated TAK1 mediates p38 MAPK activation
R-HSA-450321: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-937042: IRAK2 mediated activation of TAK1 complex
R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155: MyD88 dependent cascade initiated on endosome
R-HSA-975871: MyD88 cascade initiated on plasma membrane
R-HSA-5250968: Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250971: Toxicity of botulinum toxin type C (BoNT/C)
R-HSA-5250992: Toxicity of botulinum toxin type E (BoNT/E)
R-MMU-166058: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-MMU-168638: NOD1/2 Signaling Pathway
R-MMU-193692: Regulated proteolysis of p75NTR
R-MMU-205043: NRIF signals cell death from the nucleus
R-MMU-209560: NF-kB is activated and signals survival
R-MMU-2871837: FCERI mediated NF-kB activation
R-MMU-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-937039: IRAK1 recruits IKK complex
R-MMU-937042: IRAK2 mediated activation of TAK1 complex
R-MMU-937072: TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-975110: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-MMU-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-MMU-975144: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-MMU-975155: MyD88 dependent cascade initiated on endosome
R-MMU-975163: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-MMU-975871: MyD88 cascade initiated on plasma membrane
R-MMU-203641: NOSTRIN mediated eNOS trafficking
R-MMU-373753: Nephrin family interactions
R-MMU-5663213: RHO GTPases Activate WASPs and WAVEs
R-HSA-445095: Interaction between L1 and Ankyrins
R-HSA-6807878: COPI-mediated anterograde transport
R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6811440: Retrograde transport at the Trans-Golgi-Network
R-MMU-3371571: HSF1-dependent transactivation
R-MMU-438066: Unblocking of NMDA receptors, glutamate binding and activation
R-MMU-5576892: Phase 0 - rapid depolarisation
R-MMU-5578775: Ion homeostasis
R-MMU-936837: Ion transport by P-type ATPases
R-BTA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-BTA-879415: Advanced glycosylation endproduct receptor signaling
R-BTA-933542: TRAF6 mediated NF-kB activation
R-MMU-170984: ARMS-mediated activation
R-MMU-372708: p130Cas linkage to MAPK signaling for integrins
R-HSA-72163: mRNA Splicing - Major Pathway
R-MMU-426486: Small interfering RNA (siRNA) biogenesis
R-SCE-2029482: Regulation of actin dynamics for phagocytic cup formation
R-SCE-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-SCE-389359: CD28 dependent Vav1 pathway
R-SCE-445144: Signal transduction by L1
R-SCE-5627123: RHO GTPases activate PAKs
R-SCE-5687128: MAPK6/MAPK4 signaling
R-HSA-164940: Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-216083: Integrin cell surface interactions
R-HSA-8949275: RUNX3 Regulates Immune Response and Cell Migration
R-SCE-8854214: TBC/RABGAPs
R-SCE-8873719: RAB geranylgeranylation
R-HSA-432720: Lysosome Vesicle Biogenesis
R-HSA-162592: Integration of provirus
R-HSA-168271: Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276: NS1 Mediated Effects on Host Pathways
R-HSA-180910: Vpr-mediated nuclear import of PICs
R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs
R-SCE-204005: COPII-mediated vesicle transport
R-SCE-6807878: COPI-mediated anterograde transport
R-SCE-6811438: Intra-Golgi traffic
R-BTA-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2559585: Oncogene Induced Senescence
R-HSA-6804760: Regulation of TP53 Activity through Methylation
R-HSA-69541: Stabilization of p53
R-HSA-212436: Generic Transcription Pathway
R-SCE-3371453: Regulation of HSF1-mediated heat shock response
R-HSA-9006335: Signaling by Erythropoietin
R-HSA-9027283: Erythropoietin activates STAT5
R-HSA-1234176: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236978: Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084: Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113: SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154: APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534: Vpu mediated degradation of CD4
R-HSA-180585: Vif-mediated degradation of APOBEC3G
R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253: Degradation of beta-catenin by the destruction complex
R-HSA-211733: Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-349425: Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562: Regulation of ornithine decarboxylase (ODC)
R-HSA-5358346: Hedgehog ligand biogenesis
R-HSA-5362768: Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5610780: Degradation of GLI1 by the proteasome
R-HSA-5610783: Degradation of GLI2 by the proteasome
R-HSA-5610785: GLI3 is processed to GLI3R by the proteasome
R-HSA-5668541: TNFR2 non-canonical NF-kB pathway
R-HSA-5676590: NIK-->noncanonical NF-kB signaling
R-HSA-5678895: Defective CFTR causes cystic fibrosis
R-HSA-68827: CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949: Orc1 removal from chromatin
R-HSA-69017: CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69481: G2/M Checkpoints
R-HSA-69601: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276: The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-9010553: Regulation of expression of SLITs and ROBOs
R-HSA-373753: Nephrin family interactions
R-HSA-438066: Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-9617324: Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9620244: Long-term potentiation
R-HSA-419812: Calcitonin-like ligand receptors
R-SCE-1632852: Macroautophagy
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures
R-HSA-446107: Type I hemidesmosome assembly
R-MMU-75157: FasL/ CD95L signaling
R-MMU-75158: TRAIL signaling
R-HSA-205043: NRIF signals cell death from the nucleus
R-RNO-432720: Lysosome Vesicle Biogenesis
R-MMU-166166: MyD88-independent TLR4 cascade
R-MMU-5686938: Regulation of TLR by endogenous ligand
R-HSA-3371497: HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-MMU-202427: Phosphorylation of CD3 and TCR zeta chains
R-MMU-389948: PD-1 signaling
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-5627117: RHO GTPases Activate ROCKs
R-HSA-5627123: RHO GTPases activate PAKs
R-HSA-1362277: Transcription of E2F targets under negative control by DREAM complex
R-DME-209159: Assembly of the CI containing complexes
R-DME-209338: Assembly of the 'signalling complexes'
R-DME-209360: Ubiquitination and proteolysis of phosphorylated CI
R-DME-216119: Activation of CI
R-DME-216217: Activation of SMO
R-MMU-451308: Activation of Ca-permeable Kainate Receptor
R-MMU-5682910: LGI-ADAM interactions
R-MMU-8849932: Synaptic adhesion-like molecules
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671: RUNX3 regulates YAP1-mediated transcription
R-MMU-936440: Negative regulators of DDX58/IFIH1 signaling
R-HSA-8949613: Cristae formation
R-HSA-373752: Netrin-1 signaling
R-HSA-164843: 2-LTR circle formation
R-HSA-175567: Integration of viral DNA into host genomic DNA
R-HSA-177539: Autointegration results in viral DNA circles
R-HSA-180689: APOBEC3G mediated resistance to HIV-1 infection
R-HSA-2995383: Initiation of Nuclear Envelope Reformation
R-HSA-75153: Apoptotic execution phase
R-HSA-5368286: Mitochondrial translation initiation
R-HSA-5419276: Mitochondrial translation termination
R-HSA-8874211: CREB3 factors activate genes
R-HSA-5684264: MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-190377: FGFR2b ligand binding and activation
R-HSA-2033519: Activated point mutants of FGFR2
R-HSA-5654727: Negative regulation of FGFR2 signaling
R-HSA-427359: SIRT1 negatively regulates rRNA expression
R-HSA-73614: Pyrimidine salvage
R-HSA-159227: Transport of the SLBP independent Mature mRNA
R-HSA-159230: Transport of the SLBP Dependant Mature mRNA
R-HSA-159231: Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-168325: Viral Messenger RNA Synthesis
R-HSA-170822: Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746: Nuclear import of Rev protein
R-HSA-191859: snRNP Assembly
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-3232142: SUMOylation of ubiquitinylation proteins
R-HSA-3301854: Nuclear Pore Complex (NPC) Disassembly
R-HSA-4085377: SUMOylation of SUMOylation proteins
R-HSA-4570464: SUMOylation of RNA binding proteins
R-HSA-4615885: SUMOylation of DNA replication proteins
R-HSA-5578749: Transcriptional regulation by small RNAs
R-HSA-6784531: tRNA processing in the nucleus
R-HSA-2453864: Retinoid cycle disease events
R-HSA-2453902: The canonical retinoid cycle in rods (twilight vision)
R-HSA-3000171: Non-integrin membrane-ECM interactions
R-HSA-975634: Retinoid metabolism and transport
R-RNO-1236974: ER-Phagosome pathway
R-HSA-888568: GABA synthesis
R-HSA-9022927: MECP2 regulates transcription of genes involved in GABA signaling
R-HSA-1566977: Fibronectin matrix formation
R-HSA-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-211976: Endogenous sterols
R-HSA-3214815: HDACs deacetylate histones
R-MMU-114516: Disinhibition of SNARE formation
R-HSA-8985947: Interleukin-9 signaling
R-HSA-9020958: Interleukin-21 signaling
R-HSA-400511: Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
R-MMU-141444: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813: Separation of Sister Chromatids
R-MMU-2500257: Resolution of Sister Chromatid Cohesion
R-MMU-2565942: Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259: Loss of Nlp from mitotic centrosomes
R-MMU-380270: Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284: Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320: Recruitment of NuMA to mitotic centrosomes
R-MMU-5663220: RHO GTPases Activate Formins
R-MMU-68877: Mitotic Prometaphase
R-MMU-8852276: The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854518: AURKA Activation by TPX2
R-DME-212676: Dopamine Neurotransmitter Release Cycle
R-MMU-1369062: ABC transporters in lipid homeostasis
R-MMU-2168880: Scavenging of heme from plasma
R-MMU-3000471: Scavenging by Class B Receptors
R-MMU-8963888: Chylomicron assembly
R-MMU-8963896: HDL assembly
R-MMU-8963901: Chylomicron remodeling
R-MMU-8964011: HDL clearance
R-MMU-8964058: HDL remodeling
R-MMU-975634: Retinoid metabolism and transport
R-MMU-3371453: Regulation of HSF1-mediated heat shock response
R-HSA-162585: Uncoating of the HIV Virion
R-HSA-162594: Early Phase of HIV Life Cycle
R-HSA-164516: Minus-strand DNA synthesis
R-HSA-164525: Plus-strand DNA synthesis
R-HSA-173107: Binding and entry of HIV virion
R-HSA-175474: Assembly Of The HIV Virion
R-HSA-2025928: Calcineurin activates NFAT
R-HSA-210991: Basigin interactions
R-RNO-73817: Purine ribonucleoside monophosphate biosynthesis
R-HSA-5625970: RHO GTPases activate KTN1
R-MMU-418457: cGMP effects
R-HSA-1839122: Signaling by activated point mutants of FGFR1
R-HSA-1839130: Signaling by activated point mutants of FGFR3
R-HSA-190322: FGFR4 ligand binding and activation
R-HSA-190372: FGFR3c ligand binding and activation
R-HSA-190373: FGFR1c ligand binding and activation
R-HSA-190374: FGFR1c and Klotho ligand binding and activation
R-HSA-190375: FGFR2c ligand binding and activation
R-HSA-2033514: FGFR3 mutant receptor activation
R-HSA-5654687: Downstream signaling of activated FGFR1
R-HSA-5654726: Negative regulation of FGFR1 signaling
R-HSA-5654732: Negative regulation of FGFR3 signaling
R-HSA-5654733: Negative regulation of FGFR4 signaling
R-HSA-5658623: FGFRL1 modulation of FGFR1 signaling
R-MMU-3000157: Laminin interactions
R-MMU-8874081: MET activates PTK2 signaling
R-HSA-2029481: FCGR activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-389356: CD28 co-stimulation
R-HSA-5690714: CD22 mediated BCR regulation
R-HSA-69231: Cyclin D associated events in G1
R-HSA-75892: Platelet Adhesion to exposed collagen
R-HSA-447038: NrCAM interactions
R-HSA-451308: Activation of Ca-permeable Kainate Receptor
R-HSA-5682910: LGI-ADAM interactions
R-HSA-8849932: Synaptic adhesion-like molecules
R-HSA-1679131: Trafficking and processing of endosomal TLR
R-HSA-3000480: Scavenging by Class A Receptors
R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-111448: Activation of NOXA and translocation to mitochondria
R-HSA-139915: Activation of PUMA and translocation to mitochondria
R-HSA-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence
R-HSA-3232118: SUMOylation of transcription factors
R-HSA-6803205: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803207: TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-6803211: TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804115: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-6804116: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804754: Regulation of TP53 Expression
R-HSA-6811555: PI5P Regulates TP53 Acetylation
R-HSA-69895: Transcriptional activation of cell cycle inhibitor p21
R-HSA-2644607: Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
R-HSA-2173796: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-6807505: RNA polymerase II transcribes snRNA genes
R-HSA-190840: Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190861: Gap junction assembly
R-HSA-389977: Post-chaperonin tubulin folding pathway
R-HSA-5617833: Cilium Assembly
R-HSA-5626467: RHO GTPases activate IQGAPs
R-HSA-8955332: Carboxyterminal post-translational modifications of tubulin
R-HSA-9619483: Activation of AMPK downstream of NMDARs
R-HSA-5689901: Metalloprotease DUBs
R-HSA-5362517: Signaling by Retinoic Acid
R-HSA-8949215: Mitochondrial calcium ion transport
R-HSA-1236977: Endosomal/Vacuolar pathway
R-HSA-2172127: DAP12 interactions
R-HSA-877300: Interferon gamma signaling
R-HSA-110330: Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331: Cleavage of the damaged purine
R-HSA-110357: Displacement of DNA glycosylase by APEX1
R-HSA-9608287: Defective MUTYH substrate binding
R-HSA-9608290: Defective MUTYH substrate processing
R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA
R-HSA-3270619: IRF3-mediated induction of type I IFN
R-HSA-5693571: Nonhomologous End-Joining (NHEJ)
R-HSA-196299: Beta-catenin phosphorylation cascade
R-HSA-432142: Platelet sensitization by LDL
R-HSA-5339716: Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747: S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749: S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751: S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752: T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337: APC truncation mutants have impaired AXIN binding
R-HSA-5467340: AXIN missense mutants destabilize the destruction complex
R-HSA-5467348: Truncations of AMER1 destabilize the destruction complex
R-HSA-6803157: Antimicrobial peptides
R-HSA-156902: Peptide chain elongation
R-HSA-1799339: SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823: Viral mRNA Translation
R-HSA-2408557: Selenocysteine synthesis
R-HSA-72764: Eukaryotic Translation Termination
R-HSA-975956: Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-5576894: Phase 1 - inactivation of fast Na+ channels
R-HSA-1221632: Meiotic synapsis
R-HSA-171306: Packaging Of Telomere Ends
R-HSA-376176: Signaling by ROBO receptors
R-HSA-428542: Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-428543: Inactivation of CDC42 and RAC1
R-HSA-428890: Role of ABL in ROBO-SLIT signaling
R-HSA-8985586: SLIT2:ROBO1 increases RHOA activity
R-HSA-166663: Initial triggering of complement
R-HSA-156842: Eukaryotic Translation Elongation
R-HSA-3371511: HSF1 activation
R-HSA-8876725: Protein methylation
R-RNO-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-RNO-879415: Advanced glycosylation endproduct receptor signaling
R-RNO-933542: TRAF6 mediated NF-kB activation
R-HSA-749476: RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061: RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066: RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-SCE-3299685: Detoxification of Reactive Oxygen Species
R-SCE-5628897: TP53 Regulates Metabolic Genes
R-MMU-201688: WNT mediated activation of DVL
R-MMU-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-1971475: A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928: HS-GAG biosynthesis
R-HSA-2024096: HS-GAG degradation
R-HSA-3000157: Laminin interactions
R-HSA-3560783: Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801: Defective B3GAT3 causes JDSSDHD
R-HSA-3656237: Defective EXT2 causes exostoses 2
R-HSA-3656253: Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332: Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-450341: Activation of the AP-1 family of transcription factors
R-HSA-8862803: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-3371571: HSF1-dependent transactivation
R-HSA-447041: CHL1 interactions
R-HSA-3299685: Detoxification of Reactive Oxygen Species
R-HSA-72187: mRNA 3'-end processing
R-MMU-376176: Signaling by ROBO receptors
R-HSA-77289: Mitochondrial Fatty Acid Beta-Oxidation
R-MMU-1227986: Signaling by ERBB2
R-MMU-177929: Signaling by EGFR
R-MMU-2029481: FCGR activation
R-MMU-418592: ADP signalling through P2Y purinoceptor 1
R-MMU-418594: G alpha (i) signalling events
R-MMU-69231: Cyclin D associated events in G1
R-MMU-8934903: Receptor Mediated Mitophagy
R-MMU-9603381: Activated NTRK3 signals through PI3K
R-HSA-8878166: Transcriptional regulation by RUNX2
R-HSA-4411364: Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-4641265: Repression of WNT target genes
R-HSA-8951430: RUNX3 regulates WNT signaling
R-DME-1251985: Nuclear signaling by ERBB4
R-DME-180292: GAB1 signalosome
R-DME-2454202: Fc epsilon receptor (FCERI) signaling
R-DME-373753: Nephrin family interactions
R-DME-3928663: EPHA-mediated growth cone collapse
R-DME-3928664: Ephrin signaling
R-DME-418555: G alpha (s) signalling events
R-DME-418592: ADP signalling through P2Y purinoceptor 1
R-DME-418594: G alpha (i) signalling events
R-DME-418885: DCC mediated attractive signaling
R-DME-8934903: Receptor Mediated Mitophagy
R-HSA-5601884: PIWI-interacting RNA (piRNA) biogenesis
R-SCE-165159: mTOR signalling
R-MMU-111932: CaMK IV-mediated phosphorylation of CREB
R-MMU-111957: Cam-PDE 1 activation
R-MMU-163615: PKA activation
R-MMU-2025928: Calcineurin activates NFAT
R-MMU-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-418359: Reduction of cytosolic Ca++ levels
R-MMU-425561: Sodium/Calcium exchangers
R-MMU-442729: CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-MMU-445355: Smooth Muscle Contraction
R-MMU-5607763: CLEC7A (Dectin-1) induces NFAT activation
R-MMU-5626467: RHO GTPases activate IQGAPs
R-MMU-5627123: RHO GTPases activate PAKs
R-MMU-70221: Glycogen breakdown (glycogenolysis)
R-MMU-8876725: Protein methylation
R-MMU-9619229: Activation of RAC1 downstream of NMDARs
R-MMU-9620244: Long-term potentiation
R-HSA-8866654: E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-399954: Sema3A PAK dependent Axon repulsion
R-MMU-4641263: Regulation of FZD by ubiquitination
R-SCE-2299718: Condensation of Prophase Chromosomes
R-SCE-2559582: Senescence-Associated Secretory Phenotype (SASP)
R-SCE-9018519: Estrogen-dependent gene expression
R-HSA-110312: Translesion synthesis by REV1
R-HSA-110314: Recognition of DNA damage by PCNA-containing replication complex
R-HSA-1253288: Downregulation of ERBB4 signaling
R-HSA-168927: TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-174048: APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174490: Membrane binding and targetting of GAG proteins
R-HSA-179409: APC-Cdc20 mediated degradation of Nek2A
R-HSA-2691232: Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2979096: NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-3134975: Regulation of innate immune responses to cytosolic DNA
R-HSA-3322077: Glycogen synthesis
R-HSA-3785653: Myoclonic epilepsy of Lafora
R-HSA-4641263: Regulation of FZD by ubiquitination
R-HSA-532668: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-HSA-5655862: Translesion synthesis by POLK
R-HSA-5656121: Translesion synthesis by POLI
R-HSA-5656169: Termination of translesion DNA synthesis
R-HSA-5675482: Regulation of necroptotic cell death
R-HSA-5685942: HDR through Homologous Recombination (HRR)
R-HSA-5696394: DNA Damage Recognition in GG-NER
R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6807004: Negative regulation of MET activity
R-HSA-8875360: InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8876493: InlA-mediated entry of Listeria monocytogenes into host cells
R-HSA-901032: ER Quality Control Compartment (ERQC)
R-HSA-9013507: NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9013973: TICAM1-dependent activation of IRF3/IRF7
R-HSA-9014325: TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-917937: Iron uptake and transport
R-HSA-937039: IRAK1 recruits IKK complex
R-HSA-975110: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975144: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-MMU-5693571: Nonhomologous End-Joining (NHEJ)
R-HSA-2197563: NOTCH2 intracellular domain regulates transcription
R-HSA-75108: Activation, myristolyation of BID and translocation to mitochondria
R-HSA-194313: VEGF ligand-receptor interactions
R-HSA-195399: VEGF binds to VEGFR leading to receptor dimerization
R-HSA-2022854: Keratan sulfate biosynthesis
R-HSA-2022857: Keratan sulfate degradation
R-HSA-3656225: Defective CHST6 causes MCDC1
R-HSA-3656243: Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244: Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
R-HSA-399956: CRMPs in Sema3A signaling
R-HSA-5250924: B-WICH complex positively regulates rRNA expression
R-MMU-2454202: Fc epsilon receptor (FCERI) signaling
R-MMU-5690714: CD22 mediated BCR regulation
R-MMU-75892: Platelet Adhesion to exposed collagen
R-HSA-5602498: MyD88 deficiency (TLR2/4)
R-HSA-5602680: MyD88 deficiency (TLR5)
R-HSA-5603037: IRAK4 deficiency (TLR5)
R-HSA-5603041: IRAK4 deficiency (TLR2/4)
R-CEL-201688: WNT mediated activation of DVL
R-CEL-445144: Signal transduction by L1
R-CEL-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-9025046: NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9034013: NTF3 activates NTRK3 signaling
R-HSA-9034015: Signaling by NTRK3 (TRKC)
R-HSA-8847993: ERBB2 Activates PTK6 Signaling
R-HSA-8849468: PTK6 Regulates Proteins Involved in RNA Processing
R-HSA-8849470: PTK6 Regulates Cell Cycle
R-HSA-8849472: PTK6 Down-Regulation
R-HSA-8849473: PTK6 Expression
R-HSA-8849474: PTK6 Activates STAT3
R-HSA-8857538: PTK6 promotes HIF1A stabilization
R-HSA-1592389: Activation of Matrix Metalloproteinases
R-HSA-444821: Relaxin receptors
R-HSA-5669034: TNFs bind their physiological receptors
R-HSA-964975: Vitamins B6 activation to pyridoxal phosphate
R-MMU-428890: Role of ABL in ROBO-SLIT signaling
R-MMU-5685938: HDR through Single Strand Annealing (SSA)
R-MMU-8939236: RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-1362409: Mitochondrial iron-sulfur cluster biogenesis
R-MMU-373752: Netrin-1 signaling
R-HSA-8939245: RUNX1 regulates transcription of genes involved in BCR signaling
R-MMU-388841: Costimulation by the CD28 family
R-MMU-5654726: Negative regulation of FGFR1 signaling
R-MMU-5654727: Negative regulation of FGFR2 signaling
R-MMU-5654732: Negative regulation of FGFR3 signaling
R-MMU-5654733: Negative regulation of FGFR4 signaling
R-HSA-5693548: Sensing of DNA Double Strand Breaks
R-HSA-5693554: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568: Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579: Homologous DNA Pairing and Strand Exchange
R-HSA-912446: Meiotic recombination
R-HSA-8963888: Chylomicron assembly
R-HSA-8963901: Chylomicron remodeling
R-DME-428890: Role of ABL in ROBO-SLIT signaling
R-DME-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-8939236: RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-204626: Hypusine synthesis from eIF5A-lysine
R-HSA-4655427: SUMOylation of DNA methylation proteins
R-HSA-174577: Activation of C3 and C5
R-BTA-5578775: Ion homeostasis
R-HSA-8956319: Nucleobase catabolism
R-MMU-1810476: RIP-mediated NFkB activation via ZBP1
R-MMU-3134963: DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-113501: Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-HSA-163685: Integration of energy metabolism
R-HSA-163767: PP2A-mediated dephosphorylation of key metabolic factors
R-HSA-180024: DARPP-32 events
R-HSA-198753: ERK/MAPK targets
R-HSA-202670: ERKs are inactivated
R-HSA-2465910: MASTL Facilitates Mitotic Progression
R-HSA-70171: Glycolysis
R-HSA-9615017: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-171007: p38MAPK events
R-HSA-376172: DSCAM interactions
R-HSA-168330: Viral RNP Complexes in the Host Cell Nucleus
R-BTA-111932: CaMK IV-mediated phosphorylation of CREB
R-BTA-111957: Cam-PDE 1 activation
R-BTA-163615: PKA activation
R-BTA-418359: Reduction of cytosolic Ca++ levels
R-BTA-425561: Sodium/Calcium exchangers
R-BTA-438066: Unblocking of NMDA receptors, glutamate binding and activation
R-BTA-442729: CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-BTA-451308: Activation of Ca-permeable Kainate Receptor
R-BTA-5576892: Phase 0 - rapid depolarisation
R-BTA-5607763: CLEC7A (Dectin-1) induces NFAT activation
R-BTA-5626467: RHO GTPases activate IQGAPs
R-BTA-70221: Glycogen breakdown (glycogenolysis)
R-BTA-8876725: Protein methylation
R-BTA-936837: Ion transport by P-type ATPases
R-BTA-9619229: Activation of RAC1 downstream of NMDARs
R-BTA-9620244: Long-term potentiation
R-MMU-111447: Activation of BAD and translocation to mitochondria
R-MMU-5625740: RHO GTPases activate PKNs
R-MMU-5628897: TP53 Regulates Metabolic Genes
R-MMU-75035: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-MMU-9614399: Regulation of localization of FOXO transcription factors
R-RNO-1442490: Collagen degradation
R-RNO-1474244: Extracellular matrix organization
R-RNO-1650814: Collagen biosynthesis and modifying enzymes
R-RNO-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-2022090: Assembly of collagen fibrils and other multimeric structures
R-RNO-216083: Integrin cell surface interactions
R-RNO-2214320: Anchoring fibril formation
R-RNO-2243919: Crosslinking of collagen fibrils
R-RNO-3000178: ECM proteoglycans
R-RNO-75892: Platelet Adhesion to exposed collagen
R-RNO-8874081: MET activates PTK2 signaling
R-RNO-8948216: Collagen chain trimerization
R-MMU-163125: Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-381771: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-MMU-422085: Synthesis, secretion, and deacylation of Ghrelin
R-HSA-3065676: SUMO is conjugated to E1 (UBA2:SAE1)
R-HSA-3065678: SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-HSA-3065679: SUMO is proteolytically processed
R-HSA-877312: Regulation of IFNG signaling
R-MMU-383280: Nuclear Receptor transcription pathway
R-BTA-5686938: Regulation of TLR by endogenous ligand
R-RNO-388841: Costimulation by the CD28 family
R-RNO-5654726: Negative regulation of FGFR1 signaling
R-RNO-5654727: Negative regulation of FGFR2 signaling
R-RNO-5654732: Negative regulation of FGFR3 signaling
R-RNO-5654733: Negative regulation of FGFR4 signaling
R-RNO-6807004: Negative regulation of MET activity
R-HSA-187024: NGF-independant TRKA activation
R-HSA-418990: Adherens junctions interactions
R-MMU-6806942: MET Receptor Activation
R-MMU-8875791: MET activates STAT3
R-HSA-1538133: G0 and Early G1
R-HSA-176408: Regulation of APC/C activators between G1/S and early anaphase
R-HSA-68911: G2 Phase
R-HSA-68962: Activation of the pre-replicative complex
R-HSA-69200: Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69563: p53-Dependent G1 DNA Damage Response
R-MMU-5660668: CLEC7A/inflammasome pathway
R-MMU-75108: Activation, myristolyation of BID and translocation to mitochondria
R-MMU-75153: Apoptotic execution phase
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-1227986: Signaling by ERBB2
R-MMU-198753: ERK/MAPK targets
R-MMU-199920: CREB phosphorylation
R-MMU-2559582: Senescence-Associated Secretory Phenotype (SASP)
R-MMU-442742: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
R-MMU-444257: RSK activation
R-MMU-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-MMU-5205685: Pink/Parkin Mediated Mitophagy
R-MMU-5689877: Josephin domain DUBs
R-HSA-8963889: Assembly of active LPL and LIPC lipase complexes
R-MMU-3065676: SUMO is conjugated to E1 (UBA2:SAE1)
R-MMU-3065678: SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-MMU-3065679: SUMO is proteolytically processed
R-MMU-3108214: SUMOylation of DNA damage response and repair proteins
R-MMU-3232118: SUMOylation of transcription factors
R-MMU-3232142: SUMOylation of ubiquitinylation proteins
R-MMU-3899300: SUMOylation of transcription cofactors
R-MMU-4085377: SUMOylation of SUMOylation proteins
R-MMU-4090294: SUMOylation of intracellular receptors
R-MMU-4551638: SUMOylation of chromatin organization proteins
R-MMU-4570464: SUMOylation of RNA binding proteins
R-MMU-4615885: SUMOylation of DNA replication proteins
R-MMU-4655427: SUMOylation of DNA methylation proteins
R-MMU-4755510: SUMOylation of immune response proteins
R-MMU-5693607: Processing of DNA double-strand break ends
R-MMU-5696395: Formation of Incision Complex in GG-NER
R-MMU-69473: G2/M DNA damage checkpoint
R-MMU-8866904: Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-1369062: ABC transporters in lipid homeostasis
R-HSA-381038: XBP1(S) activates chaperone genes
R-HSA-163680: AMPK inhibits chREBP transcriptional activation activity
R-HSA-200425: Import of palmitoyl-CoA into the mitochondrial matrix
R-HSA-2151209: Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-5362798: Release of Hh-Np from the secreting cell
R-HSA-5632681: Ligand-receptor interactions
R-HSA-5658034: HHAT G278V abrogates palmitoylation of Hh-Np
R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones
R-HSA-381070: IRE1alpha activates chaperones
R-HSA-189085: Digestion of dietary carbohydrate
R-MMU-5610780: Degradation of GLI1 by the proteasome
R-MMU-5610785: GLI3 is processed to GLI3R by the proteasome
R-HSA-446353: Cell-extracellular matrix interactions
R-MMU-212436: Generic Transcription Pathway
R-HSA-141430: Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-176407: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176409: APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412: Phosphorylation of the APC/C
R-HSA-3371378: Regulation by c-FLIP
R-HSA-5213460: RIPK1-mediated regulated necrosis
R-HSA-5218900: CASP8 activity is inhibited
R-HSA-5357786: TNFR1-induced proapoptotic signaling
R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-HSA-69416: Dimerization of procaspase-8
R-HSA-75893: TNF signaling
R-MMU-432142: Platelet sensitization by LDL
R-MMU-912694: Regulation of IFNA signaling
R-MMU-5669034: TNFs bind their physiological receptors
R-RNO-438066: Unblocking of NMDA receptors, glutamate binding and activation
R-RNO-451308: Activation of Ca-permeable Kainate Receptor
R-RNO-8849932: Synaptic adhesion-like molecules
R-CEL-2995383: Initiation of Nuclear Envelope Reformation
R-MMU-5653890: Lactose synthesis
R-RNO-180024: DARPP-32 events
R-HSA-6802953: RAS signaling downstream of NF1 loss-of-function variants
R-HSA-9012546: Interleukin-18 signaling
R-HSA-5467333: APC truncation mutants are not K63 polyubiquitinated
R-HSA-75035: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-RNO-3065676: SUMO is conjugated to E1 (UBA2:SAE1)
R-RNO-3065678: SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-RNO-3065679: SUMO is proteolytically processed
R-RNO-3108214: SUMOylation of DNA damage response and repair proteins
R-RNO-3232118: SUMOylation of transcription factors
R-RNO-3232142: SUMOylation of ubiquitinylation proteins
R-RNO-3899300: SUMOylation of transcription cofactors
R-RNO-4085377: SUMOylation of SUMOylation proteins
R-RNO-4090294: SUMOylation of intracellular receptors
R-RNO-4551638: SUMOylation of chromatin organization proteins
R-RNO-4570464: SUMOylation of RNA binding proteins
R-RNO-4615885: SUMOylation of DNA replication proteins
R-RNO-4655427: SUMOylation of DNA methylation proteins
R-RNO-4755510: SUMOylation of immune response proteins
R-RNO-5693571: Nonhomologous End-Joining (NHEJ)
R-RNO-5696395: Formation of Incision Complex in GG-NER
R-RNO-69473: G2/M DNA damage checkpoint
R-RNO-877312: Regulation of IFNG signaling
R-RNO-8866904: Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-3295583: TRP channels
R-HSA-9013957: TLR3-mediated TICAM1-dependent programmed cell death
R-HSA-3000471: Scavenging by Class B Receptors
R-HSA-8963896: HDL assembly
R-HSA-8964011: HDL clearance
R-CFA-5578775: Ion homeostasis
R-HSA-388841: Costimulation by the CD28 family
R-HSA-9014843: Interleukin-33 signaling
R-HSA-167161: HIV Transcription Initiation
R-HSA-167162: RNA Polymerase II HIV Promoter Escape
R-HSA-167172: Transcription of the HIV genome
R-HSA-73776: RNA Polymerase II Promoter Escape
R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953: RNA Polymerase II Transcription Initiation
R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-6803529: FGFR2 alternative splicing
R-MMU-1250342: PI3K events in ERBB4 signaling
R-HSA-2022870: Chondroitin sulfate biosynthesis
R-HSA-2022923: Dermatan sulfate biosynthesis
R-HSA-2024101: CS/DS degradation
R-HSA-3595172: Defective CHST3 causes SEDCJD
R-HSA-3595174: Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177: Defective CHSY1 causes TPBS
R-MMU-111995: phospho-PLA2 pathway
R-MMU-112409: RAF-independent MAPK1/3 activation
R-MMU-112411: MAPK1 (ERK2) activation
R-MMU-162658: Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-170968: Frs2-mediated activation
R-MMU-202670: ERKs are inactivated
R-MMU-445144: Signal transduction by L1
R-MMU-450341: Activation of the AP-1 family of transcription factors
R-HSA-189200: Cellular hexose transport
R-HSA-203927: MicroRNA (miRNA) biogenesis
R-HSA-426486: Small interfering RNA (siRNA) biogenesis
R-HSA-426496: Post-transcriptional silencing by small RNAs
R-HSA-8934593: Regulation of RUNX1 Expression and Activity
R-HSA-8948700: Competing endogenous RNAs (ceRNAs) regulate PTEN translation
R-HSA-9022692: Regulation of MECP2 expression and activity
R-RNO-193692: Regulated proteolysis of p75NTR
R-RNO-205043: NRIF signals cell death from the nucleus
R-RNO-9013507: NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-1650814: Collagen biosynthesis and modifying enzymes
R-HSA-2243919: Crosslinking of collagen fibrils
R-HSA-111458: Formation of apoptosome
R-HSA-111459: Activation of caspases through apoptosome-mediated cleavage
R-HSA-111463: SMAC (DIABLO) binds to IAPs
R-HSA-111464: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
R-HSA-418889: Caspase activation via Dependence Receptors in the absence of ligand
R-HSA-9627069: Regulation of the apoptosome activity
R-HSA-173736: Alternative complement activation
R-HSA-8985801: Regulation of cortical dendrite branching
R-HSA-5602636: IKBKB deficiency causes SCID
R-HSA-5603027: IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
R-HSA-844615: The AIM2 inflammasome
R-HSA-373760: L1CAM interactions
R-HSA-447043: Neurofascin interactions
R-SCE-6814122: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-111932: CaMK IV-mediated phosphorylation of CREB
R-HSA-442729: CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-CEL-4419969: Depolymerisation of the Nuclear Lamina
R-HSA-446343: Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-HSA-388844: Receptor-type tyrosine-protein phosphatases
R-DME-5696394: DNA Damage Recognition in GG-NER
R-DME-6781823: Formation of TC-NER Pre-Incision Complex
R-MMU-180024: DARPP-32 events
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-MMU-171007: p38MAPK events
R-MMU-8951936: RUNX3 regulates p14-ARF
R-HSA-3000484: Scavenging by Class F Receptors
R-HSA-3000497: Scavenging by Class H Receptors
R-HSA-5686938: Regulation of TLR by endogenous ligand
R-HSA-8866423: VLDL assembly
R-HSA-8964041: LDL remodeling
R-HSA-8964046: VLDL clearance
R-SCE-1222556: ROS and RNS production in phagocytes
R-SCE-77387: Insulin receptor recycling
R-HSA-111452: Activation and oligomerization of BAK protein
R-HSA-111453: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-114294: Activation, translocation and oligomerization of BAX
R-HSA-9026357: NTF4 activates NTRK2 (TRKB) signaling
R-HSA-1250342: PI3K events in ERBB4 signaling
R-HSA-75157: FasL/ CD95L signaling
R-HSA-75158: TRAIL signaling
R-HSA-5607763: CLEC7A (Dectin-1) induces NFAT activation
R-HSA-9032845: Activated NTRK2 signals through CDK5
R-HSA-174411: Polymerase switching on the C-strand of the telomere
R-HSA-174414: Processive synthesis on the C-strand of the telomere
R-HSA-174417: Telomere C-strand (Lagging Strand) Synthesis
R-HSA-174437: Removal of the Flap Intermediate from the C-strand
R-HSA-5358565: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5651801: PCNA-Dependent Long Patch Base Excision Repair
R-HSA-69091: Polymerase switching
R-HSA-69166: Removal of the Flap Intermediate
R-HSA-69183: Processive synthesis on the lagging strand
R-HSA-197264: Nicotinamide salvaging
R-HSA-1834941: STING mediated induction of host immune responses
R-HSA-5099900: WNT5A-dependent internalization of FZD4
R-HSA-8939242: RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
R-HSA-209563: Axonal growth stimulation
R-HSA-416550: Sema4D mediated inhibition of cell attachment and migration
R-HSA-6785631: ERBB2 Regulates Cell Motility
R-HSA-164378: PKA activation in glucagon signalling
R-HSA-198745: Signalling to STAT3
R-HSA-2892247: POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-452723: Transcriptional regulation of pluripotent stem cells
R-HSA-8875791: MET activates STAT3
R-HSA-8984722: Interleukin-35 Signalling
R-HSA-9020933: Interleukin-23 signaling
R-HSA-9020956: Interleukin-27 signaling
R-HSA-6793080: rRNA modification in the mitochondrion
R-MMU-3371497: HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-HSA-1566948: Elastic fibre formation
R-HSA-8852405: Signaling by MST1
R-BTA-1250342: PI3K events in ERBB4 signaling
R-BTA-388841: Costimulation by the CD28 family
R-BTA-912631: Regulation of signaling by CBL
R-MMU-390522: Striated Muscle Contraction
R-HSA-71032: Propionyl-CoA catabolism
R-BTA-190322: FGFR4 ligand binding and activation
R-BTA-190370: FGFR1b ligand binding and activation
R-BTA-190371: FGFR3b ligand binding and activation
R-BTA-190372: FGFR3c ligand binding and activation
R-BTA-190373: FGFR1c ligand binding and activation
R-BTA-190375: FGFR2c ligand binding and activation
R-BTA-190377: FGFR2b ligand binding and activation
R-BTA-5654687: Downstream signaling of activated FGFR1
R-BTA-5654726: Negative regulation of FGFR1 signaling
R-BTA-5654727: Negative regulation of FGFR2 signaling
R-BTA-5654732: Negative regulation of FGFR3 signaling
R-BTA-5654733: Negative regulation of FGFR4 signaling
R-DME-611105: Respiratory electron transport
R-DME-6799198: Complex I biogenesis
R-HSA-156711: Polo-like kinase mediated events
R-RNO-1227986: Signaling by ERBB2
R-RNO-1251985: Nuclear signaling by ERBB4
R-RNO-177929: Signaling by EGFR
R-RNO-2029481: FCGR activation
R-RNO-389356: CD28 co-stimulation
R-RNO-418592: ADP signalling through P2Y purinoceptor 1
R-RNO-418594: G alpha (i) signalling events
R-RNO-5663220: RHO GTPases Activate Formins
R-RNO-69231: Cyclin D associated events in G1
R-RNO-8934903: Receptor Mediated Mitophagy
R-RNO-9603381: Activated NTRK3 signals through PI3K
R-BTA-3371453: Regulation of HSF1-mediated heat shock response
R-BTA-3371497: HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-BTA-3371568: Attenuation phase
R-BTA-3371571: HSF1-dependent transactivation
R-BTA-450408: AUF1 (hnRNP D0) binds and destabilizes mRNA
R-BTA-72163: mRNA Splicing - Major Pathway
R-CEL-5610787: Hedgehog 'off' state
R-HSA-204174: Regulation of pyruvate dehydrogenase (PDH) complex
R-HSA-389661: Glyoxylate metabolism and glycine degradation
R-HSA-70268: Pyruvate metabolism
R-HSA-162658: Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-111995: phospho-PLA2 pathway
R-HSA-112409: RAF-independent MAPK1/3 activation
R-HSA-444257: RSK activation
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-163560: Triglyceride catabolism
R-HSA-1614558: Degradation of cysteine and homocysteine
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-422085: Synthesis, secretion, and deacylation of Ghrelin
R-MMU-113501: Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-MMU-195253: Degradation of beta-catenin by the destruction complex
R-MMU-196299: Beta-catenin phosphorylation cascade
R-MMU-69273: Cyclin A/B1/B2 associated events during G2/M transition
R-MMU-2559580: Oxidative Stress Induced Senescence
R-MMU-9018519: Estrogen-dependent gene expression
R-SSC-2129379: Molecules associated with elastic fibres
R-SSC-3000170: Syndecan interactions
R-SSC-8941855: RUNX3 regulates CDKN1A transcription
R-SSC-8951936: RUNX3 regulates p14-ARF
R-HSA-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-8866376: Reelin signalling pathway
R-HSA-9032500: Activated NTRK2 signals through FYN
R-HSA-9032759: NTRK2 activates RAC1
R-MMU-399954: Sema3A PAK dependent Axon repulsion
R-MMU-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956: CRMPs in Sema3A signaling
R-MMU-6803205: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-MMU-8873719: RAB geranylgeranylation
R-SCE-110056: MAPK3 (ERK1) activation
R-SCE-112411: MAPK1 (ERK2) activation
R-SCE-168638: NOD1/2 Signaling Pathway
R-SCE-450302: activated TAK1 mediates p38 MAPK activation
R-SCE-5674135: MAP2K and MAPK activation
R-SCE-5674499: Negative feedback regulation of MAPK pathway
R-SCE-6811555: PI5P Regulates TP53 Acetylation
R-HSA-499943: Interconversion of nucleotide di- and triphosphates
R-HSA-5676934: Protein repair
R-HSA-6799198: Complex I biogenesis
R-HSA-5683826: Surfactant metabolism
R-HSA-5688354: Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)
R-HSA-5688849: Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890: Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
R-HSA-3249367: STAT6-mediated induction of chemokines
R-MMU-110056: MAPK3 (ERK1) activation
R-MMU-8934593: Regulation of RUNX1 Expression and Activity
R-HSA-192905: vRNP Assembly
R-HSA-5336415: Uptake and function of diphtheria toxin
R-HSA-5578775: Ion homeostasis
R-RNO-8866654: E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-380095: Tachykinin receptors bind tachykinins
R-GGA-110320: Translesion Synthesis by POLH
R-GGA-382556: ABC-family proteins mediated transport
R-GGA-532668: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-GGA-5358346: Hedgehog ligand biogenesis
R-GGA-5689877: Josephin domain DUBs
R-GGA-8876725: Protein methylation
R-HSA-5576890: Phase 3 - rapid repolarisation
R-SCE-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-3772470: Negative regulation of TCF-dependent signaling by WNT ligand antagonists
R-HSA-5339717: Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
R-HSA-372708: p130Cas linkage to MAPK signaling for integrins
R-HSA-6806942: MET Receptor Activation
R-HSA-8874081: MET activates PTK2 signaling
R-MMU-416700: Other semaphorin interactions
R-GGA-8949664: Processing of SMDT1
R-HSA-5339700: TCF7L2 mutants don't bind CTBP
R-BTA-164378: PKA activation in glucagon signalling
R-BTA-180024: DARPP-32 events
R-BTA-2565942: Regulation of PLK1 Activity at G2/M Transition
R-BTA-380259: Loss of Nlp from mitotic centrosomes
R-BTA-380270: Recruitment of mitotic centrosome proteins and complexes
R-BTA-380284: Loss of proteins required for interphase microtubule organization from the centrosome
R-BTA-380320: Recruitment of NuMA to mitotic centrosomes
R-BTA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-BTA-422356: Regulation of insulin secretion
R-BTA-442720: CREB1 phosphorylation through the activation of Adenylate Cyclase
R-BTA-5610785: GLI3 is processed to GLI3R by the proteasome
R-BTA-8854518: AURKA Activation by TPX2
R-BTA-8963896: HDL assembly
R-HSA-2408550: Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
R-HSA-5263617: Metabolism of ingested MeSeO2H into MeSeH
R-GGA-1268020: Mitochondrial protein import
R-HSA-8851680: Butyrophilin (BTN) family interactions
R-HSA-446205: Synthesis of GDP-mannose
R-HSA-139910: Activation of BMF and translocation to mitochondria
R-MMU-111463: SMAC (DIABLO) binds to IAPs
R-MMU-111464: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
R-MMU-111469: SMAC, XIAP-regulated apoptotic response
R-MMU-5675482: Regulation of necroptotic cell death
R-HSA-416993: Trafficking of GluR2-containing AMPA receptors
R-HSA-6811438: Intra-Golgi traffic
R-HSA-1181150: Signaling by NODAL
R-HSA-1502540: Signaling by Activin
R-HSA-3311021: SMAD4 MH2 Domain Mutants in Cancer
R-HSA-8952158: RUNX3 regulates BCL2L11 (BIM) transcription
R-HSA-9617828: FOXO-mediated transcription of cell cycle genes
R-GGA-195253: Degradation of beta-catenin by the destruction complex
R-GGA-196299: Beta-catenin phosphorylation cascade
R-GGA-5250924: B-WICH complex positively regulates rRNA expression
R-DME-388844: Receptor-type tyrosine-protein phosphatases
R-HSA-166662: Lectin pathway of complement activation
R-HSA-2855086: Ficolins bind to repetitive carbohydrate structures on the target cell surface
R-HSA-351200: Interconversion of polyamines
R-HSA-6788467: IL-6-type cytokine receptor ligand interactions
R-HSA-8937144: Aryl hydrocarbon receptor signalling
R-HSA-8949664: Processing of SMDT1
R-HSA-8866911: TFAP2 (AP-2) family regulates transcription of cell cycle factors
R-HSA-5661231: Metallothioneins bind metals
R-HSA-111457: Release of apoptotic factors from the mitochondria
R-HSA-196843: Vitamin B2 (riboflavin) metabolism
R-HSA-74752: Signaling by Insulin receptor
R-HSA-77387: Insulin receptor recycling
R-HSA-190370: FGFR1b ligand binding and activation
R-HSA-190371: FGFR3b ligand binding and activation
R-HSA-8851708: Signaling by FGFR2 IIIa TM
R-HSA-73728: RNA Polymerase I Promoter Opening
R-DME-209471: Formation and transport of the N-HH ligand
R-DME-5358346: Hedgehog ligand biogenesis
R-DME-5362798: Release of Hh-Np from the secreting cell
R-DME-5632681: Ligand-receptor interactions
R-HSA-8941284: RUNX2 regulates chondrocyte maturation
R-HSA-141405: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
R-HSA-168316: Assembly of Viral Components at the Budding Site
R-HSA-111469: SMAC, XIAP-regulated apoptotic response
R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-DME-450321: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-DME-5689896: Ovarian tumor domain proteases
R-DME-9020702: Interleukin-1 signaling
R-DME-937039: IRAK1 recruits IKK complex
R-DME-937042: IRAK2 mediated activation of TAK1 complex
R-DME-937072: TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-DME-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-DME-975144: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-DME-975155: MyD88 dependent cascade initiated on endosome
R-DME-975163: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-MMU-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-MMU-2559585: Oncogene Induced Senescence
R-MMU-2559586: DNA Damage/Telomere Stress Induced Senescence
R-MMU-349425: Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-6804754: Regulation of TP53 Expression
R-MMU-6804756: Regulation of TP53 Activity through Phosphorylation
R-MMU-6804759: Regulation of TP53 Activity through Association with Co-factors
R-MMU-6804760: Regulation of TP53 Activity through Methylation
R-MMU-6811555: PI5P Regulates TP53 Acetylation
R-MMU-69481: G2/M Checkpoints
R-MMU-69541: Stabilization of p53
R-MMU-69895: Transcriptional activation of cell cycle inhibitor p21
R-MMU-8941855: RUNX3 regulates CDKN1A transcription
R-HSA-429947: Deadenylation of mRNA
R-HSA-72662: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-BTA-425381: Bicarbonate transporters
R-RNO-2173796: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-RNO-350054: Notch-HLH transcription pathway
R-RNO-72163: mRNA Splicing - Major Pathway
R-RNO-8941856: RUNX3 regulates NOTCH signaling
R-DME-163615: PKA activation
R-DME-164378: PKA activation in glucagon signalling
R-DME-180024: DARPP-32 events
R-DME-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-DME-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-DME-442720: CREB1 phosphorylation through the activation of Adenylate Cyclase
R-DME-5610785: GLI3 is processed to GLI3R by the proteasome
R-DME-5610787: Hedgehog 'off' state
R-HSA-113507: E2F-enabled inhibition of pre-replication complex formation
R-HSA-176417: Phosphorylation of Emi1
R-HSA-2299718: Condensation of Prophase Chromosomes
R-HSA-2980767: Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-4419969: Depolymerisation of the Nuclear Lamina
R-HSA-68875: Mitotic Prophase
R-HSA-69478: G2/M DNA replication checkpoint
R-HSA-844455: The NLRP1 inflammasome
R-HSA-167590: Nef Mediated CD4 Down-regulation
R-MMU-499943: Interconversion of nucleotide di- and triphosphates
R-RNO-111995: phospho-PLA2 pathway
R-RNO-112409: RAF-independent MAPK1/3 activation
R-RNO-112411: MAPK1 (ERK2) activation
R-RNO-162658: Golgi Cisternae Pericentriolar Stack Reorganization
R-RNO-170968: Frs2-mediated activation
R-RNO-198753: ERK/MAPK targets
R-RNO-202670: ERKs are inactivated
R-RNO-2559582: Senescence-Associated Secretory Phenotype (SASP)
R-RNO-445144: Signal transduction by L1
R-RNO-450341: Activation of the AP-1 family of transcription factors
R-RNO-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-352238: Breakdown of the nuclear lamina
R-HSA-168179: Toll Like Receptor TLR1:TLR2 Cascade
R-MMU-1834941: STING mediated induction of host immune responses
R-MMU-3134975: Regulation of innate immune responses to cytosolic DNA
R-MMU-1237044: Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1475029: Reversible hydration of carbon dioxide
R-MMU-2453902: The canonical retinoid cycle in rods (twilight vision)
R-HSA-163282: Mitochondrial transcription initiation
R-HSA-8931987: RUNX1 regulates estrogen receptor mediated transcription
R-HSA-8939256: RUNX1 regulates transcription of genes involved in WNT signaling
R-HSA-166665: Terminal pathway of complement
R-GGA-5628897: TP53 Regulates Metabolic Genes
R-MMU-389356: CD28 co-stimulation
R-MMU-9032759: NTRK2 activates RAC1
R-CFA-194313: VEGF ligand-receptor interactions
R-CFA-195399: VEGF binds to VEGFR leading to receptor dimerization
R-HSA-418886: Netrin mediated repulsion signals
R-SCE-114608: Platelet degranulation
R-SCE-5696395: Formation of Incision Complex in GG-NER
R-MMU-186797: Signaling by PDGF
R-HSA-2393930: Phosphate bond hydrolysis by NUDT proteins
R-GGA-170984: ARMS-mediated activation
R-GGA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-3249367: STAT6-mediated induction of chemokines
R-MMU-3270619: IRF3-mediated induction of type I IFN
R-MMU-9008059: Interleukin-37 signaling
R-RNO-141444: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-2467813: Separation of Sister Chromatids
R-RNO-2500257: Resolution of Sister Chromatid Cohesion
R-RNO-68877: Mitotic Prometaphase
R-SCE-2132295: MHC class II antigen presentation
R-MMU-201722: Formation of the beta-catenin:TCF transactivating complex
R-MMU-3247509: Chromatin modifying enzymes
R-HSA-9010642: ROBO receptors bind AKAP5
R-MMU-166663: Initial triggering of complement
R-MMU-173623: Classical antibody-mediated complement activation
R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-6785470: tRNA processing in the mitochondrion
R-HSA-6787450: tRNA modification in the mitochondrion
R-HSA-70895: Branched-chain amino acid catabolism
R-HSA-8868766: rRNA processing in the mitochondrion
R-HSA-6782315: tRNA modification in the nucleus and cytosol
R-MMU-8866376: Reelin signalling pathway
R-HSA-71403: Citric acid cycle (TCA cycle)
R-RNO-5625970: RHO GTPases activate KTN1
R-HSA-351906: Apoptotic cleavage of cell adhesion proteins
R-HSA-804914: Transport of fatty acids
R-HSA-5340588: RNF mutants show enhanced WNT signaling and proliferation
R-HSA-390247: Beta-oxidation of very long chain fatty acids
R-HSA-1474244: Extracellular matrix organization
R-HSA-2214320: Anchoring fibril formation
R-HSA-8948216: Collagen chain trimerization
R-BTA-8963889: Assembly of active LPL and LIPC lipase complexes
R-MMU-532668: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-MMU-427359: SIRT1 negatively regulates rRNA expression
R-MMU-9617629: Regulation of FOXO transcriptional activity by acetylation
R-MMU-110320: Translesion Synthesis by POLH
R-MMU-3371511: HSF1 activation
R-MMU-382556: ABC-family proteins mediated transport
R-HSA-8854521: Interaction between PHLDA1 and AURKA
R-HSA-210747: Regulation of gene expression in early pancreatic precursor cells
R-MMU-111452: Activation and oligomerization of BAK protein
R-MMU-114294: Activation, translocation and oligomerization of BAX
R-DME-1810476: RIP-mediated NFkB activation via ZBP1
R-DME-209442: Formation of the trans-membrane 'signalling complex'
R-DME-214842: DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
R-DME-214844: DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
R-DME-214862: Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'
R-DME-214863: Adaptor protein complex binds to TL receptor at the plasma membrane
R-DME-214869: Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
R-DME-214874: PLL kinase binds to TUB in the TL receptor 'signalling complex'
R-DME-3134963: DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-1606341: IRF3 mediated activation of type 1 IFN
R-RNO-2559580: Oxidative Stress Induced Senescence
R-RNO-450321: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-MMU-110314: Recognition of DNA damage by PCNA-containing replication complex
R-MMU-5696394: DNA Damage Recognition in GG-NER
R-MMU-5696400: Dual Incision in GG-NER
R-MMU-6781823: Formation of TC-NER Pre-Incision Complex
R-MMU-6782135: Dual incision in TC-NER
R-MMU-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-RNO-5682910: LGI-ADAM interactions
R-CEL-1369062: ABC transporters in lipid homeostasis
R-MMU-418990: Adherens junctions interactions
R-MMU-446353: Cell-extracellular matrix interactions
R-HSA-163210: Formation of ATP by chemiosmotic coupling
R-RNO-8873719: RAB geranylgeranylation
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-MMU-202430: Translocation of ZAP-70 to Immunological synapse
R-HSA-9020591: Interleukin-12 signaling
R-MMU-5250924: B-WICH complex positively regulates rRNA expression
R-MMU-5620924: Intraflagellar transport
R-MMU-376172: DSCAM interactions
R-MMU-450302: activated TAK1 mediates p38 MAPK activation
R-MMU-6783783: Interleukin-10 signaling
R-MMU-8984722: Interleukin-35 Signalling
R-MMU-9020933: Interleukin-23 signaling
R-MMU-9020956: Interleukin-27 signaling
R-HSA-8941326: RUNX2 regulates bone development
R-MMU-3134973: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
R-MMU-351906: Apoptotic cleavage of cell adhesion proteins
R-MMU-8951430: RUNX3 regulates WNT signaling
R-HSA-77111: Synthesis of Ketone Bodies
R-RNO-1059683: Interleukin-6 signaling
R-RNO-110056: MAPK3 (ERK1) activation
R-RNO-389948: PD-1 signaling
R-RNO-8854691: Interleukin-20 family signaling
R-RNO-8934593: Regulation of RUNX1 Expression and Activity
R-RNO-909733: Interferon alpha/beta signaling
R-RNO-912694: Regulation of IFNA signaling
R-RNO-936964: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-1461957: Beta defensins
R-HSA-1461973: Defensins
R-HSA-177929: Signaling by EGFR
R-HSA-8941333: RUNX2 regulates genes involved in differentiation of myeloid cells
R-RNO-373080: Class B/2 (Secretin family receptors)
R-DME-1358803: Downregulation of ERBB2:ERBB3 signaling
R-HSA-8869496: TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
R-HSA-917977: Transferrin endocytosis and recycling
R-MMU-8983711: OAS antiviral response
R-HSA-444473: Formyl peptide receptors bind formyl peptides and many other ligands
R-MMU-8866652: Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-379716: Cytosolic tRNA aminoacylation
R-HSA-5602571: TRAF3 deficiency - HSE
R-HSA-1660662: Glycosphingolipid metabolism
R-HSA-9013700: NOTCH4 Activation and Transmission of Signal to the Nucleus
R-MMU-2682334: EPH-Ephrin signaling
R-DME-5627123: RHO GTPases activate PAKs
R-HSA-70263: Gluconeogenesis
R-HSA-2473224: Antagonism of Activin by Follistatin
R-HSA-167060: NGF processing
R-HSA-187042: TRKA activation by NGF
R-HSA-193670: p75NTR negatively regulates cell cycle via SC1
R-HSA-193681: Ceramide signalling
R-HSA-205017: NFG and proNGF binds to p75NTR
R-HSA-205025: NADE modulates death signalling
R-HSA-427413: NoRC negatively regulates rRNA expression
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-73772: RNA Polymerase I Promoter Escape
R-HSA-73863: RNA Polymerase I Transcription Termination
R-DME-1268020: Mitochondrial protein import
R-DME-163210: Formation of ATP by chemiosmotic coupling
R-DME-8949613: Cristae formation
R-MMU-1482922: Acyl chain remodelling of PI
R-MMU-165158: Activation of AKT2
R-MMU-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-418889: Caspase activation via Dependence Receptors in the absence of ligand
R-MMU-1660517: Synthesis of PIPs at the late endosome membrane
R-MMU-444473: Formyl peptide receptors bind formyl peptides and many other ligands
R-MMU-165181: Inhibition of TSC complex formation by PKB
R-MMU-8866427: VLDLR internalisation and degradation
R-MMU-177504: Retrograde neurotrophin signalling
R-RNO-2871837: FCERI mediated NF-kB activation
R-RNO-373752: Netrin-1 signaling
R-RNO-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-RNO-5625740: RHO GTPases activate PKNs
R-RNO-177504: Retrograde neurotrophin signalling
R-RNO-203641: NOSTRIN mediated eNOS trafficking
R-RNO-444473: Formyl peptide receptors bind formyl peptides and many other ligands
R-RNO-1306955: GRB7 events in ERBB2 signaling
R-RNO-9020558: Interleukin-2 signaling
R-RNO-8866427: VLDLR internalisation and degradation
R-SPO-432720: Lysosome Vesicle Biogenesis
R-SPO-8856825: Cargo recognition for clathrin-mediated endocytosis
R-SPO-3238698: WNT ligand biogenesis and trafficking
R-SPO-5689880: Ub-specific processing proteases
R-DDI-114508: Effects of PIP2 hydrolysis
R-DDI-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-DDI-983189: Kinesins
R-DDI-1660499: Synthesis of PIPs at the plasma membrane
R-DDI-1855204: Synthesis of IP3 and IP4 in the cytosol
R-DDI-199418: Negative regulation of the PI3K/AKT network
R-DDI-5689880: Ub-specific processing proteases
R-DDI-5689896: Ovarian tumor domain proteases
R-DDI-8948747: Regulation of PTEN localization
R-DDI-8948751: Regulation of PTEN stability and activity
R-SCE-432720: Lysosome Vesicle Biogenesis
R-SCE-5689880: Ub-specific processing proteases
R-SCE-3238698: WNT ligand biogenesis and trafficking
R-SCE-1660499: Synthesis of PIPs at the plasma membrane
R-SCE-1660514: Synthesis of PIPs at the Golgi membrane
R-SCE-1660516: Synthesis of PIPs at the early endosome membrane
R-SCE-5668599: RHO GTPases Activate NADPH Oxidases
R-SCE-8856825: Cargo recognition for clathrin-mediated endocytosis
R-SCE-1660517: Synthesis of PIPs at the late endosome membrane
R-CEL-1660499: Synthesis of PIPs at the plasma membrane
R-CEL-1632852: Macroautophagy
R-CEL-5668599: RHO GTPases Activate NADPH Oxidases
R-DME-5654689: PI-3K cascade:FGFR1
R-DME-5654695: PI-3K cascade:FGFR2
R-DME-5654710: PI-3K cascade:FGFR3
R-DME-5654720: PI-3K cascade:FGFR4
R-DME-182971: EGFR downregulation
R-DME-373752: Netrin-1 signaling
R-DRE-446353: Cell-extracellular matrix interactions
R-DRE-1483248: Synthesis of PIPs at the ER membrane
R-GGA-177504: Retrograde neurotrophin signalling
R-HSA-1482788: Acyl chain remodelling of PC
R-HSA-1482839: Acyl chain remodelling of PE
R-HSA-1482922: Acyl chain remodelling of PI
R-HSA-1482925: Acyl chain remodelling of PG
R-HSA-1483115: Hydrolysis of LPC
R-HSA-9022699: MECP2 regulates neuronal receptors and channels
R-HSA-203641: NOSTRIN mediated eNOS trafficking
R-HSA-165158: Activation of AKT2
R-HSA-165160: PDE3B signalling
R-HSA-165181: Inhibition of TSC complex formation by PKB
R-HSA-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-1222556: ROS and RNS production in phagocytes
R-HSA-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-CFA-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-SSC-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-BTA-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-BTA-1306955: GRB7 events in ERBB2 signaling
R-DME-5218921: VEGFR2 mediated cell proliferation
R-MMU-450520: HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-1306955: GRB7 events in ERBB2 signaling
R-MMU-8964315: G beta:gamma signalling through BTK
R-MMU-1306955: GRB7 events in ERBB2 signaling
R-MMU-1253288: Downregulation of ERBB4 signaling
R-GGA-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-HSA-947581: Molybdenum cofactor biosynthesis
R-BTA-5099900: WNT5A-dependent internalization of FZD4
R-BTA-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-MMU-163359: Glucagon signaling in metabolic regulation
R-MMU-164378: PKA activation in glucagon signalling
R-MMU-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392851: Prostacyclin signalling through prostacyclin receptor
R-MMU-420092: Glucagon-type ligand receptors
R-MMU-1660662: Glycosphingolipid metabolism
R-MMU-4085001: Sialic acid metabolism
R-MMU-112311: Neurotransmitter clearance
R-MMU-1483191: Synthesis of PC
R-SSC-5099900: WNT5A-dependent internalization of FZD4
R-SSC-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-MMU-196791: Vitamin D (calciferol) metabolism
R-MMU-211916: Vitamins
R-HSA-5210891: Uptake and function of anthrax toxins
R-DME-211916: Vitamins
R-DME-5365859: RA biosynthesis pathway
R-DRE-5389840: Mitochondrial translation elongation
R-DRE-5419276: Mitochondrial translation termination
R-BTA-6807878: COPI-mediated anterograde transport
R-BTA-6811440: Retrograde transport at the Trans-Golgi-Network
R-RNO-2142670: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-RNO-2142816: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-RNO-5423646: Aflatoxin activation and detoxification
R-RNO-9018681: Biosynthesis of protectins
R-RNO-9027307: Biosynthesis of maresin-like SPMs
R-SPO-6803204: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-BTA-6803157: Antimicrobial peptides
R-HSA-6799990: Metal sequestration by antimicrobial proteins
R-CFA-6807878: COPI-mediated anterograde transport
R-MMU-75109: Triglyceride biosynthesis
R-RNO-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-3301854: Nuclear Pore Complex (NPC) Disassembly
R-RNO-1482883: Acyl chain remodeling of DAG and TAG
R-RNO-426048: Arachidonate production from DAG
R-RNO-156827: L13a-mediated translational silencing of Ceruloplasmin expression
R-RNO-6791226: Major pathway of rRNA processing in the nucleolus and cytosol
R-RNO-72649: Translation initiation complex formation
R-RNO-72689: Formation of a pool of free 40S subunits
R-RNO-72695: Formation of the ternary complex, and subsequently, the 43S complex
R-RNO-72702: Ribosomal scanning and start codon recognition
R-RNO-72706: GTP hydrolysis and joining of the 60S ribosomal subunit
R-RNO-975957: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-GGA-6811440: Retrograde transport at the Trans-Golgi-Network
R-CEL-212676: Dopamine Neurotransmitter Release Cycle
R-RNO-416993: Trafficking of GluR2-containing AMPA receptors
R-RNO-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-SPO-111457: Release of apoptotic factors from the mitochondria
R-DME-2142789: Ubiquinol biosynthesis
R-RNO-373760: L1CAM interactions
R-MMU-5576894: Phase 1 - inactivation of fast Na+ channels
R-MMU-264876: Insulin processing
R-DME-2243919: Crosslinking of collagen fibrils
R-RNO-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-RNO-193807: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-RNO-211976: Endogenous sterols
R-DME-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-DME-5423646: Aflatoxin activation and detoxification
R-SPO-8854214: TBC/RABGAPs
R-SPO-8934903: Receptor Mediated Mitophagy
R-GGA-5205685: Pink/Parkin Mediated Mitophagy
R-GGA-8934903: Receptor Mediated Mitophagy
R-BTA-71288: Creatine metabolism
R-RNO-6811440: Retrograde transport at the Trans-Golgi-Network
R-RNO-5652227: Fructose biosynthesis
R-RNO-5661270: Formation of xylulose-5-phosphate
R-MMU-189483: Heme degradation
R-MMU-917937: Iron uptake and transport
R-HSA-446210: Synthesis of UDP-N-acetyl-glucosamine
R-MMU-204626: Hypusine synthesis from eIF5A-lysine
R-HSA-114516: Disinhibition of SNARE formation
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
R-RNO-6807878: COPI-mediated anterograde transport
R-GGA-372987: The tricarboxylic acid cycle
R-GGA-71403: Citric acid cycle (TCA cycle)
R-MMU-211981: Xenobiotics
R-MMU-211999: CYP2E1 reactions
R-MMU-2142670: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-MMU-2142816: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-MMU-9027307: Biosynthesis of maresin-like SPMs
R-HSA-1483226: Synthesis of PI
R-DDI-6799198: Complex I biogenesis
R-RNO-611105: Respiratory electron transport
R-RNO-6799198: Complex I biogenesis
R-SPO-9033241: Peroxisomal protein import
R-SPO-6804756: Regulation of TP53 Activity through Phosphorylation
R-DDI-204005: COPII-mediated vesicle transport
R-DDI-5694530: Cargo concentration in the ER
R-DDI-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-HSA-2466712: Biosynthesis of A2E, implicated in retinal degradation
R-MMU-73817: Purine ribonucleoside monophosphate biosynthesis
R-CEL-5099900: WNT5A-dependent internalization of FZD4
R-MMU-1234176: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-74217: Purine salvage
R-BTA-5389840: Mitochondrial translation elongation
R-BTA-5419276: Mitochondrial translation termination
R-BTA-5620922: BBSome-mediated cargo-targeting to cilium
R-CEL-112311: Neurotransmitter clearance
R-CEL-1483191: Synthesis of PC
R-CFA-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-BTA-611105: Respiratory electron transport
R-BTA-6799198: Complex I biogenesis
R-DDI-6807878: COPI-mediated anterograde transport
R-DDI-6811438: Intra-Golgi traffic
R-MMU-1358803: Downregulation of ERBB2:ERBB3 signaling
R-DME-204005: COPII-mediated vesicle transport
R-DME-5694530: Cargo concentration in the ER
R-DME-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-XTR-200425: Import of palmitoyl-CoA into the mitochondrial matrix
R-DRE-196025: Formation of annular gap junctions
R-SPO-71403: Citric acid cycle (TCA cycle)
R-RNO-1222556: ROS and RNS production in phagocytes
R-RNO-77387: Insulin receptor recycling
R-RNO-917977: Transferrin endocytosis and recycling
R-RNO-983712: Ion channel transport
R-MMU-5365859: RA biosynthesis pathway
R-HSA-2142789: Ubiquinol biosynthesis
R-RNO-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-SSC-189451: Heme biosynthesis
R-DME-114516: Disinhibition of SNARE formation
R-DME-449836: Other interleukin signaling
R-SSC-5357905: Regulation of TNFR1 signaling
R-SSC-5357956: TNFR1-induced NFkappaB signaling pathway
R-MMU-6814122: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-BTA-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-BTA-191859: snRNP Assembly
R-BTA-3108214: SUMOylation of DNA damage response and repair proteins
R-BTA-3301854: Nuclear Pore Complex (NPC) Disassembly
R-BTA-4615885: SUMOylation of DNA replication proteins
R-DRE-611105: Respiratory electron transport
R-DRE-6799198: Complex I biogenesis
R-MMU-446343: Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-BTA-264876: Insulin processing
R-SPO-110320: Translesion Synthesis by POLH
R-HSA-75109: Triglyceride biosynthesis
R-HSA-2142688: Synthesis of 5-eicosatetraenoic acids
R-SCE-165158: Activation of AKT2
R-SCE-199418: Negative regulation of the PI3K/AKT network
R-DME-71403: Citric acid cycle (TCA cycle)
R-RNO-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-SSC-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-611105: Respiratory electron transport
R-MMU-6799198: Complex I biogenesis
R-MMU-211935: Fatty acids
R-MMU-5423646: Aflatoxin activation and detoxification
R-RNO-2142691: Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-RNO-2142712: Synthesis of 12-eicosatetraenoic acid derivatives
R-RNO-2142770: Synthesis of 15-eicosatetraenoic acid derivatives
R-RNO-9023661: Biosynthesis of E-series 18(R)-resolvins
R-BTA-140180: COX reactions
R-BTA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-CEL-75153: Apoptotic execution phase
R-SSC-5205685: Pink/Parkin Mediated Mitophagy
R-SSC-8934903: Receptor Mediated Mitophagy
R-MMU-112308: Presynaptic depolarization and calcium channel opening
R-MMU-5576893: Phase 2 - plateau phase
R-RNO-1660662: Glycosphingolipid metabolism
R-DRE-141444: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-DRE-2467813: Separation of Sister Chromatids
R-DRE-2500257: Resolution of Sister Chromatid Cohesion
R-DRE-5663220: RHO GTPases Activate Formins
R-RNO-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-DME-211976: Endogenous sterols
R-MMU-5689901: Metalloprotease DUBs
R-RNO-447043: Neurofascin interactions
R-SPO-204005: COPII-mediated vesicle transport
R-SPO-5694530: Cargo concentration in the ER
R-SPO-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-MMU-163210: Formation of ATP by chemiosmotic coupling
R-MMU-8949613: Cristae formation
R-CFA-5099900: WNT5A-dependent internalization of FZD4
R-CFA-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-DDI-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-DME-189451: Heme biosynthesis
R-SPO-5689901: Metalloprotease DUBs
R-XTR-611105: Respiratory electron transport
R-XTR-6799198: Complex I biogenesis
R-SPO-6807878: COPI-mediated anterograde transport
R-SPO-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-SSC-156590: Glutathione conjugation
R-DME-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3301854: Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453: Regulation of HSF1-mediated heat shock response
R-DME-4551638: SUMOylation of chromatin organization proteins
R-DME-4615885: SUMOylation of DNA replication proteins
R-MMU-389887: Beta-oxidation of pristanoyl-CoA
R-MMU-9033241: Peroxisomal protein import
R-CFA-196108: Pregnenolone biosynthesis
R-CFA-211976: Endogenous sterols
R-SCE-1358803: Downregulation of ERBB2:ERBB3 signaling
R-MMU-1222556: ROS and RNS production in phagocytes
R-MMU-77387: Insulin receptor recycling
R-MMU-917977: Transferrin endocytosis and recycling
R-MMU-983712: Ion channel transport
R-DME-6807878: COPI-mediated anterograde transport
R-DME-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-SPO-8866427: VLDLR internalisation and degradation
R-SPO-8964038: LDL clearance
R-HSA-2142691: Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142712: Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142770: Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-9018677: Biosynthesis of DHA-derived SPMs
R-HSA-9018681: Biosynthesis of protectins
R-HSA-9018896: Biosynthesis of E-series 18(S)-resolvins
R-HSA-9023661: Biosynthesis of E-series 18(R)-resolvins
R-HSA-9025106: Biosynthesis of DPAn-6 SPMs
R-HSA-9026286: Biosynthesis of DPAn-3-derived protectins and resolvins
R-CEL-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-1650814: Collagen biosynthesis and modifying enzymes
R-MMU-9020591: Interleukin-12 signaling
R-CEL-3299685: Detoxification of Reactive Oxygen Species
R-DRE-438066: Unblocking of NMDA receptors, glutamate binding and activation
R-DRE-451308: Activation of Ca-permeable Kainate Receptor
R-DRE-8849932: Synaptic adhesion-like molecules
R-XTR-6807878: COPI-mediated anterograde transport
R-MMU-166665: Terminal pathway of complement
R-MMU-6803157: Antimicrobial peptides
R-BTA-212676: Dopamine Neurotransmitter Release Cycle
R-BTA-6799990: Metal sequestration by antimicrobial proteins
R-SCE-74259: Purine catabolism
R-SCE-9018896: Biosynthesis of E-series 18(S)-resolvins
R-RNO-170670: Adenylate cyclase inhibitory pathway
R-RNO-202040: G-protein activation
R-RNO-392170: ADP signalling through P2Y purinoceptor 12
R-RNO-400042: Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-6814122: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-193807: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-MMU-211976: Endogenous sterols
R-RNO-9033241: Peroxisomal protein import
R-RNO-6799990: Metal sequestration by antimicrobial proteins
R-RNO-5223345: Miscellaneous transport and binding events
R-XTR-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-XTR-191859: snRNP Assembly
R-XTR-3108214: SUMOylation of DNA damage response and repair proteins
R-XTR-3301854: Nuclear Pore Complex (NPC) Disassembly
R-XTR-3371453: Regulation of HSF1-mediated heat shock response
R-XTR-4615885: SUMOylation of DNA replication proteins
R-CEL-156711: Polo-like kinase mediated events
R-CEL-69273: Cyclin A/B1/B2 associated events during G2/M transition
R-CEL-69478: G2/M DNA replication checkpoint
R-DDI-432720: Lysosome Vesicle Biogenesis
R-BTA-373760: L1CAM interactions
R-MMU-71403: Citric acid cycle (TCA cycle)
R-HSA-5365859: RA biosynthesis pathway
R-SCE-8866427: VLDLR internalisation and degradation
R-SCE-8964038: LDL clearance
R-MMU-196741: Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-211935: Fatty acids
R-HSA-211958: Miscellaneous substrates
R-HSA-211979: Eicosanoids
R-HSA-5579005: Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
R-RNO-3238698: WNT ligand biogenesis and trafficking
R-HSA-5423646: Aflatoxin activation and detoxification
R-DRE-189451: Heme biosynthesis
R-HSA-211981: Xenobiotics
R-HSA-211999: CYP2E1 reactions
R-HSA-211945: Phase I - Functionalization of compounds
R-DRE-1237112: Methionine salvage pathway
R-MMU-888568: GABA synthesis
R-MMU-8866654: E3 ubiquitin ligases ubiquitinate target proteins
R-SPO-191273: Cholesterol biosynthesis
R-RNO-6811555: PI5P Regulates TP53 Acetylation
R-RNO-8847453: Synthesis of PIPs in the nucleus
R-RNO-211935: Fatty acids
R-RNO-211958: Miscellaneous substrates
R-RNO-211979: Eicosanoids
R-RNO-888568: GABA synthesis
R-RNO-189483: Heme degradation
R-RNO-917937: Iron uptake and transport
R-MMU-422356: Regulation of insulin secretion
R-RNO-5389840: Mitochondrial translation elongation
R-RNO-5419276: Mitochondrial translation termination
R-MMU-1483226: Synthesis of PI
R-MMU-5620922: BBSome-mediated cargo-targeting to cilium
R-DRE-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-392154: Nitric oxide stimulates guanylate cyclase
R-XTR-5099900: WNT5A-dependent internalization of FZD4
R-BTA-1268020: Mitochondrial protein import
R-HSA-71288: Creatine metabolism
R-SCE-163765: ChREBP activates metabolic gene expression
R-SCE-196780: Biotin transport and metabolism
R-SCE-200425: Import of palmitoyl-CoA into the mitochondrial matrix
R-SCE-75105: Fatty acyl-CoA biosynthesis
R-SCE-1483248: Synthesis of PIPs at the ER membrane
R-MMU-1268020: Mitochondrial protein import
R-MMU-211958: Miscellaneous substrates
R-HSA-5223345: Miscellaneous transport and binding events
R-DRE-5250924: B-WICH complex positively regulates rRNA expression
R-DRE-196108: Pregnenolone biosynthesis
R-DRE-211976: Endogenous sterols
R-MMU-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-MMU-5223345: Miscellaneous transport and binding events
R-DRE-5620922: BBSome-mediated cargo-targeting to cilium
R-HSA-182218: Nef Mediated CD8 Down-regulation
R-HSA-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-BTA-189451: Heme biosynthesis
R-RNO-5578775: Ion homeostasis
R-CFA-189451: Heme biosynthesis
R-SSC-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-RNO-75896: Plasmalogen biosynthesis
R-RNO-211981: Xenobiotics
R-RNO-211999: CYP2E1 reactions
R-CFA-611105: Respiratory electron transport
R-CFA-6799198: Complex I biogenesis
R-MMU-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-DME-5099900: WNT5A-dependent internalization of FZD4
R-DME-8964038: LDL clearance
R-SPO-983168: Antigen processing: Ubiquitination & Proteasome degradation
R-MMU-74217: Purine salvage
R-RNO-6803157: Antimicrobial peptides
R-SCE-1483206: Glycerophospholipid biosynthesis
R-SCE-1660661: Sphingolipid de novo biosynthesis
R-SCE-1660662: Glycosphingolipid metabolism
R-SCE-390471: Association of TriC/CCT with target proteins during biosynthesis
R-DME-5620916: VxPx cargo-targeting to cilium
R-SPO-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-RNO-5250924: B-WICH complex positively regulates rRNA expression
R-MMU-193775: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-DME-6811438: Intra-Golgi traffic
R-BTA-2142691: Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-BTA-2142712: Synthesis of 12-eicosatetraenoic acid derivatives
R-BTA-2142770: Synthesis of 15-eicosatetraenoic acid derivatives
R-BTA-9023661: Biosynthesis of E-series 18(R)-resolvins
R-CFA-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-GGA-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-CEL-3000170: Syndecan interactions
R-BTA-399956: CRMPs in Sema3A signaling
R-BTA-6804756: Regulation of TP53 Activity through Phosphorylation
R-DDI-2142789: Ubiquinol biosynthesis
R-HSA-2142816: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-446199: Synthesis of Dolichyl-phosphate
R-HSA-4755609: Defective DHDDS causes retinitis pigmentosa 59
R-RNO-264876: Insulin processing
R-SCE-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-DRE-71403: Citric acid cycle (TCA cycle)
R-SCE-499943: Interconversion of nucleotide di- and triphosphates
R-SCE-844456: The NLRP3 inflammasome
R-MMU-197264: Nicotinamide salvaging
R-MMU-2142770: Synthesis of 15-eicosatetraenoic acid derivatives
R-MMU-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-MMU-9018679: Biosynthesis of EPA-derived SPMs
R-MMU-9025094: Biosynthesis of DPAn-3 SPMs
R-MMU-9027604: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
R-XTR-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-MMU-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-9627069: Regulation of the apoptosome activity
R-HSA-75876: Synthesis of very long-chain fatty acyl-CoAs
R-XTR-203615: eNOS activation
R-XTR-210991: Basigin interactions
R-XTR-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-BTA-114516: Disinhibition of SNARE formation
R-BTA-1169091: Activation of NF-kappaB in B cells
R-BTA-4419969: Depolymerisation of the Nuclear Lamina
R-BTA-76005: Response to elevated platelet cytosolic Ca2+
R-DRE-200425: Import of palmitoyl-CoA into the mitochondrial matrix
R-DDI-8854214: TBC/RABGAPs
R-DDI-8873719: RAB geranylgeranylation
R-DDI-8876198: RAB GEFs exchange GTP for GDP on RABs
R-SCE-446199: Synthesis of Dolichyl-phosphate
R-BTA-8849932: Synaptic adhesion-like molecules
R-SSC-6791226: Major pathway of rRNA processing in the nucleolus and cytosol
R-SSC-72649: Translation initiation complex formation
R-SSC-72689: Formation of a pool of free 40S subunits
R-SSC-72702: Ribosomal scanning and start codon recognition
R-SSC-975957: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-RNO-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2142670: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-XTR-75896: Plasmalogen biosynthesis
R-XTR-9033241: Peroxisomal protein import
R-DRE-112311: Neurotransmitter clearance
R-DRE-1483191: Synthesis of PC
R-SSC-166665: Terminal pathway of complement
R-SSC-6803157: Antimicrobial peptides
R-CFA-1237112: Methionine salvage pathway
R-SCE-162658: Golgi Cisternae Pericentriolar Stack Reorganization
R-GGA-611105: Respiratory electron transport
R-GGA-6799198: Complex I biogenesis
R-HSA-1296072: Voltage gated Potassium channels
R-HSA-189451: Heme biosynthesis
R-SSC-611105: Respiratory electron transport
R-SSC-6799198: Complex I biogenesis
R-MMU-5652227: Fructose biosynthesis
R-MMU-5661270: Formation of xylulose-5-phosphate
R-RNO-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-BTA-1222556: ROS and RNS production in phagocytes
R-BTA-77387: Insulin receptor recycling
R-BTA-917977: Transferrin endocytosis and recycling
R-BTA-983712: Ion channel transport
R-HSA-8847453: Synthesis of PIPs in the nucleus
R-CFA-211981: Xenobiotics
R-CFA-211999: CYP2E1 reactions
R-CFA-9027307: Biosynthesis of maresin-like SPMs
R-MMU-211945: Phase I - Functionalization of compounds
R-SPO-446199: Synthesis of Dolichyl-phosphate
R-MMU-6799990: Metal sequestration by antimicrobial proteins
R-HSA-983712: Ion channel transport
R-RNO-166208: mTORC1-mediated signalling
R-RNO-3371571: HSF1-dependent transactivation
R-RNO-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-RNO-5628897: TP53 Regulates Metabolic Genes
R-RNO-8943724: Regulation of PTEN gene transcription
R-BTA-6814122: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-SSC-71403: Citric acid cycle (TCA cycle)
R-SSC-8849932: Synaptic adhesion-like molecules
R-DRE-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859: snRNP Assembly
R-DRE-3108214: SUMOylation of DNA damage response and repair proteins
R-DRE-3301854: Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453: Regulation of HSF1-mediated heat shock response
R-DRE-6811438: Intra-Golgi traffic
R-DRE-6811440: Retrograde transport at the Trans-Golgi-Network
R-DME-201688: WNT mediated activation of DVL
R-DME-209440: Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
R-DME-350368: Activation of RHO1 by FZ:DSH complex
R-DME-350369: Negative feedback loop regulates asymmetric localisation
R-DME-350376: Activation of RAC1:GTP by FZ:DSH complex
R-DME-350411: Formation and asymmetric localisation of transmembrane complexes
R-DME-350480: Activation of non-muscle Myosin II
R-DME-4086400: PCP/CE pathway
R-DME-4641258: Degradation of DVL
R-DME-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-DME-5663220: RHO GTPases Activate Formins
R-DRE-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-DRE-75153: Apoptotic execution phase
R-BTA-76061: RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-BTA-76066: RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-BTA-76071: RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-9027307: Biosynthesis of maresin-like SPMs
R-BTA-189483: Heme degradation
R-BTA-917937: Iron uptake and transport
R-MMU-1181150: Signaling by NODAL
R-MMU-9617828: FOXO-mediated transcription of cell cycle genes
R-BTA-8963888: Chylomicron assembly
R-BTA-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-RNO-71403: Citric acid cycle (TCA cycle)
R-DME-5654726: Negative regulation of FGFR1 signaling
R-DME-5654727: Negative regulation of FGFR2 signaling
R-DME-5654732: Negative regulation of FGFR3 signaling
R-DME-5654733: Negative regulation of FGFR4 signaling
R-DME-193775: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-CFA-112411: MAPK1 (ERK2) activation
R-CFA-445144: Signal transduction by L1
R-DRE-5423646: Aflatoxin activation and detoxification
R-PFA-204005: COPII-mediated vesicle transport
R-PFA-5694530: Cargo concentration in the ER
R-PFA-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-MMU-5389840: Mitochondrial translation elongation
R-MMU-5419276: Mitochondrial translation termination
R-CFA-210991: Basigin interactions
R-CFA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5545619: XAV939 inhibits tankyrase, stabilizing AXIN
R-SCE-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-211979: Eicosanoids
R-MMU-2142691: Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-DDI-947581: Molybdenum cofactor biosynthesis
R-GGA-196108: Pregnenolone biosynthesis
R-GGA-211976: Endogenous sterols
R-BTA-5661270: Formation of xylulose-5-phosphate
R-SCE-9033241: Peroxisomal protein import
R-XTR-5205685: Pink/Parkin Mediated Mitophagy
R-XTR-8934903: Receptor Mediated Mitophagy
R-DME-8849932: Synaptic adhesion-like molecules
R-HSA-77595: Processing of Intronless Pre-mRNAs
R-BTA-1237112: Methionine salvage pathway
R-CEL-6811438: Intra-Golgi traffic
R-HSA-5661270: Formation of xylulose-5-phosphate
R-HSA-5662853: Essential pentosuria
R-HSA-1855183: Synthesis of IP2, IP, and Ins in the cytosol
R-DDI-8856825: Cargo recognition for clathrin-mediated endocytosis
R-GGA-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-SPO-75153: Apoptotic execution phase
R-BTA-168638: NOD1/2 Signaling Pathway
R-BTA-5357956: TNFR1-induced NFkappaB signaling pathway
R-BTA-937042: IRAK2 mediated activation of TAK1 complex
R-BTA-937072: TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-BTA-975163: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-DRE-5576892: Phase 0 - rapid depolarisation
R-DME-209209: Formation of the activated receptor complex
R-DME-209228: Formation of the activated STAT92E dimer and transport to the nucleus
R-DME-210688: Dephosphorylation by PTP61F phosphatases
R-DME-9020558: Interleukin-2 signaling
R-HSA-2485179: Activation of the phototransduction cascade
R-RNO-5689901: Metalloprotease DUBs
R-RNO-5658623: FGFRL1 modulation of FGFR1 signaling
R-RNO-5626467: RHO GTPases activate IQGAPs
R-SPO-1483248: Synthesis of PIPs at the ER membrane
R-SPO-1660499: Synthesis of PIPs at the plasma membrane
R-XTR-2142789: Ubiquinol biosynthesis
R-HSA-2142700: Synthesis of Lipoxins (LX)
R-HSA-9018676: Biosynthesis of D-series resolvins
R-HSA-9018682: Biosynthesis of maresins
R-HSA-9020265: Biosynthesis of aspirin-triggered D-series resolvins
R-HSA-9026290: Biosynthesis of DPAn-3-derived maresins
R-HSA-9026403: Biosynthesis of DPAn-3-derived 13-series resolvins
R-HSA-9027604: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
R-CFA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-CFA-5686938: Regulation of TLR by endogenous ligand
R-CFA-879415: Advanced glycosylation endproduct receptor signaling
R-CFA-933542: TRAF6 mediated NF-kB activation
R-DME-3371497: HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-BTA-1660662: Glycosphingolipid metabolism
R-GGA-212676: Dopamine Neurotransmitter Release Cycle
R-SCE-1257604: PIP3 activates AKT signaling
R-SCE-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-SCE-166208: mTORC1-mediated signalling
R-SCE-198693: AKT phosphorylates targets in the nucleus
R-SCE-198753: ERK/MAPK targets
R-SCE-203615: eNOS activation
R-SCE-375165: NCAM signaling for neurite out-growth
R-SCE-389513: CTLA4 inhibitory signaling
R-SCE-444257: RSK activation
R-SCE-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-SCE-6804757: Regulation of TP53 Degradation
R-SCE-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SCE-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-MMU-77111: Synthesis of Ketone Bodies
R-SPO-6811440: Retrograde transport at the Trans-Golgi-Network
R-RNO-196108: Pregnenolone biosynthesis
R-RNO-2395516: Electron transport from NADPH to Ferredoxin
R-CEL-5223345: Miscellaneous transport and binding events
R-SCE-6803204: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-74217: Purine salvage
R-DDI-193648: NRAGE signals death through JNK
R-DRE-212676: Dopamine Neurotransmitter Release Cycle
R-SSC-193144: Estrogen biosynthesis
R-SSC-211976: Endogenous sterols
R-BTA-211916: Vitamins
R-MMU-156590: Glutathione conjugation
R-CFA-140180: COX reactions
R-CFA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-RNO-5357786: TNFR1-induced proapoptotic signaling
R-RNO-5357905: Regulation of TNFR1 signaling
R-RNO-5357956: TNFR1-induced NFkappaB signaling pathway
R-BTA-141444: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-BTA-2467813: Separation of Sister Chromatids
R-BTA-2500257: Resolution of Sister Chromatid Cohesion
R-BTA-5663220: RHO GTPases Activate Formins
R-BTA-68877: Mitotic Prometaphase
R-DRE-77111: Synthesis of Ketone Bodies
R-RNO-389887: Beta-oxidation of pristanoyl-CoA
R-MMU-75876: Synthesis of very long-chain fatty acyl-CoAs
R-MMU-166208: mTORC1-mediated signalling
R-MMU-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-8943724: Regulation of PTEN gene transcription
R-RNO-5205685: Pink/Parkin Mediated Mitophagy
R-RNO-1234176: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-6799198: Complex I biogenesis
R-SSC-1237112: Methionine salvage pathway
R-CEL-71403: Citric acid cycle (TCA cycle)
R-HSA-193144: Estrogen biosynthesis
R-HSA-5579030: Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
R-MMU-8964046: VLDL clearance
R-CFA-156827: L13a-mediated translational silencing of Ceruloplasmin expression
R-CFA-72649: Translation initiation complex formation
R-CFA-72702: Ribosomal scanning and start codon recognition
R-SCE-163680: AMPK inhibits chREBP transcriptional activation activity
R-RNO-5576892: Phase 0 - rapid depolarisation
R-RNO-936837: Ion transport by P-type ATPases
R-HSA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-9018679: Biosynthesis of EPA-derived SPMs
R-HSA-9025094: Biosynthesis of DPAn-3 SPMs
R-CFA-6811440: Retrograde transport at the Trans-Golgi-Network
R-BTA-71403: Citric acid cycle (TCA cycle)
R-CEL-1650814: Collagen biosynthesis and modifying enzymes
R-HSA-1483213: Synthesis of PE
R-SCE-1483191: Synthesis of PC
R-SCE-389887: Beta-oxidation of pristanoyl-CoA
R-SCE-5362517: Signaling by Retinoic Acid
R-SCE-169911: Regulation of Apoptosis
R-DME-195253: Degradation of beta-catenin by the destruction complex
R-DME-196299: Beta-catenin phosphorylation cascade
R-DME-201681: TCF dependent signaling in response to WNT
R-DME-201722: Formation of the beta-catenin:TCF transactivating complex
R-DME-209396: Phosphorylation of ARM
R-DME-209407: Transport of ARM to the nucleus
R-DME-209413: Assembly of the 'destruction complex'
R-DME-209421: Transcription activation by ARM
R-DME-209461: Ubiquitination and degradation of phosphorylated ARM
R-DME-3134973: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
R-DME-351906: Apoptotic cleavage of cell adhesion proteins
R-DME-3769402: Deactivation of the beta-catenin transactivating complex
R-DME-4086398: Ca2+ pathway
R-DME-8951430: RUNX3 regulates WNT signaling
R-SPO-75876: Synthesis of very long-chain fatty acyl-CoAs
R-HSA-211916: Vitamins
R-HSA-5579015: Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
R-RNO-75876: Synthesis of very long-chain fatty acyl-CoAs
R-MMU-71288: Creatine metabolism
R-SSC-1059683: Interleukin-6 signaling
R-SSC-112411: MAPK1 (ERK2) activation
R-SSC-6785807: Interleukin-4 and Interleukin-13 signaling
R-SSC-6788467: IL-6-type cytokine receptor ligand interactions
R-SSC-69231: Cyclin D associated events in G1
R-SSC-877312: Regulation of IFNG signaling
R-SSC-8854691: Interleukin-20 family signaling
R-SSC-8984722: Interleukin-35 Signalling
R-SSC-9020591: Interleukin-12 signaling
R-SSC-9020933: Interleukin-23 signaling
R-SSC-9020956: Interleukin-27 signaling
R-MMU-196108: Pregnenolone biosynthesis
R-MMU-2395516: Electron transport from NADPH to Ferredoxin
R-DRE-2142789: Ubiquinol biosynthesis
R-BTA-8866654: E3 ubiquitin ligases ubiquitinate target proteins
R-BTA-9033241: Peroxisomal protein import
R-CEL-2142789: Ubiquinol biosynthesis
R-DDI-9033241: Peroxisomal protein import
R-MMU-2142688: Synthesis of 5-eicosatetraenoic acids
R-DDI-5689901: Metalloprotease DUBs
R-HSA-73780: RNA Polymerase III Chain Elongation
R-HSA-73980: RNA Polymerase III Transcription Termination
R-HSA-76071: RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-RNO-1296072: Voltage gated Potassium channels
R-SCE-75876: Synthesis of very long-chain fatty acyl-CoAs
R-SCE-77289: Mitochondrial Fatty Acid Beta-Oxidation
R-RNO-5358346: Hedgehog ligand biogenesis
R-RNO-8963888: Chylomicron assembly
R-RNO-9020591: Interleukin-12 signaling
R-MMU-9018681: Biosynthesis of protectins
R-MMU-1296072: Voltage gated Potassium channels
R-BTA-75109: Triglyceride biosynthesis
R-RNO-1483226: Synthesis of PI
R-BTA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-5658623: FGFRL1 modulation of FGFR1 signaling
R-RNO-77289: Mitochondrial Fatty Acid Beta-Oxidation
R-MMU-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-MMU-1482883: Acyl chain remodeling of DAG and TAG
R-MMU-426048: Arachidonate production from DAG
R-BTA-2142789: Ubiquinol biosynthesis
R-SCE-6811440: Retrograde transport at the Trans-Golgi-Network
R-RNO-189451: Heme biosynthesis
R-HSA-196791: Vitamin D (calciferol) metabolism
R-HSA-5579027: Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
R-BTA-264870: Caspase-mediated cleavage of cytoskeletal proteins
R-XTR-212676: Dopamine Neurotransmitter Release Cycle
R-XTR-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-SCE-2142789: Ubiquinol biosynthesis
R-RNO-211916: Vitamins
R-CFA-193993: Mineralocorticoid biosynthesis
R-DME-9018681: Biosynthesis of protectins
R-HSA-389887: Beta-oxidation of pristanoyl-CoA
R-MMU-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-3301854: Nuclear Pore Complex (NPC) Disassembly
R-DRE-210991: Basigin interactions
R-DRE-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-DME-2142691: Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-156581: Methylation
R-HSA-211957: Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
R-DRE-1222556: ROS and RNS production in phagocytes
R-DRE-77387: Insulin receptor recycling
R-DRE-917977: Transferrin endocytosis and recycling
R-DRE-983712: Ion channel transport
R-SSC-75896: Plasmalogen biosynthesis
R-SSC-9033241: Peroxisomal protein import
R-XTR-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-SSC-193993: Mineralocorticoid biosynthesis
R-HSA-162599: Late Phase of HIV Life Cycle
R-SCE-111457: Release of apoptotic factors from the mitochondria
R-RNO-432142: Platelet sensitization by LDL
R-SSC-5627117: RHO GTPases Activate ROCKs
R-MMU-76061: RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066: RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071: RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-RNO-2142789: Ubiquinol biosynthesis
R-RNO-351906: Apoptotic cleavage of cell adhesion proteins
R-CFA-71403: Citric acid cycle (TCA cycle)
R-BTA-204626: Hypusine synthesis from eIF5A-lysine
R-RNO-210991: Basigin interactions
R-RNO-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-DRE-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-XTR-438066: Unblocking of NMDA receptors, glutamate binding and activation
R-XTR-451308: Activation of Ca-permeable Kainate Receptor
R-XTR-8849932: Synaptic adhesion-like molecules
R-DDI-2046106: alpha-linolenic acid (ALA) metabolism
R-DDI-75876: Synthesis of very long-chain fatty acyl-CoAs
R-CEL-5205685: Pink/Parkin Mediated Mitophagy
R-MMU-77289: Mitochondrial Fatty Acid Beta-Oxidation
R-MMU-156827: L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-6791226: Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-72649: Translation initiation complex formation
R-MMU-72689: Formation of a pool of free 40S subunits
R-MMU-72695: Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702: Ribosomal scanning and start codon recognition
R-RNO-446343: Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-BTA-5357786: TNFR1-induced proapoptotic signaling
R-BTA-5357905: Regulation of TNFR1 signaling
R-DME-193048: Androgen biosynthesis
R-DME-194002: Glucocorticoid biosynthesis
R-DDI-5632684: Hedgehog 'on' state
R-DDI-8934903: Receptor Mediated Mitophagy
R-HSA-5579000: Defective CYP1B1 causes Glaucoma
R-RNO-2565942: Regulation of PLK1 Activity at G2/M Transition
R-RNO-3371497: HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-RNO-380259: Loss of Nlp from mitotic centrosomes
R-RNO-380270: Recruitment of mitotic centrosome proteins and complexes
R-RNO-380284: Loss of proteins required for interphase microtubule organization from the centrosome
R-RNO-380320: Recruitment of NuMA to mitotic centrosomes
R-RNO-8854518: AURKA Activation by TPX2
R-MMU-196757: Metabolism of folate and pterines
R-MMU-140180: COX reactions
R-CEL-446343: Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-BTA-5250924: B-WICH complex positively regulates rRNA expression
R-DDI-71403: Citric acid cycle (TCA cycle)
R-MMU-191273: Cholesterol biosynthesis
R-SPO-1483206: Glycerophospholipid biosynthesis
R-SPO-1660662: Glycosphingolipid metabolism
R-HSA-156590: Glutathione conjugation
R-MMU-2142712: Synthesis of 12-eicosatetraenoic acid derivatives
R-MMU-9023661: Biosynthesis of E-series 18(R)-resolvins
R-GGA-416993: Trafficking of GluR2-containing AMPA receptors
R-GGA-8964038: LDL clearance
R-MMU-5627117: RHO GTPases Activate ROCKs
R-CFA-446388: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-RNO-8866376: Reelin signalling pathway
R-MMU-170670: Adenylate cyclase inhibitory pathway
R-MMU-202040: G-protein activation
R-MMU-392170: ADP signalling through P2Y purinoceptor 12
R-MMU-400042: Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-5624138: Trafficking of myristoylated proteins to the cilium
R-HSA-5652227: Fructose biosynthesis
R-SPO-2142789: Ubiquinol biosynthesis
R-BTA-2453902: The canonical retinoid cycle in rods (twilight vision)
R-BTA-5365859: RA biosynthesis pathway
R-DME-196108: Pregnenolone biosynthesis
R-DME-2395516: Electron transport from NADPH to Ferredoxin
R-DDI-189451: Heme biosynthesis
R-CEL-438066: Unblocking of NMDA receptors, glutamate binding and activation
R-SCE-191273: Cholesterol biosynthesis
R-RNO-156590: Glutathione conjugation
R-MMU-2024096: HS-GAG degradation
R-CFA-5205685: Pink/Parkin Mediated Mitophagy
R-CFA-8934903: Receptor Mediated Mitophagy
R-SCE-3371571: HSF1-dependent transactivation
R-CFA-5625970: RHO GTPases activate KTN1
R-CFA-5626467: RHO GTPases activate IQGAPs
R-CFA-5663220: RHO GTPases Activate Formins
R-CFA-8964616: G beta:gamma signalling through CDC42
R-BTA-166208: mTORC1-mediated signalling
R-BTA-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-BTA-5628897: TP53 Regulates Metabolic Genes
R-BTA-8943724: Regulation of PTEN gene transcription
R-HSA-2395516: Electron transport from NADPH to Ferredoxin
R-HSA-5579026: Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
R-MMU-156711: Polo-like kinase mediated events
R-MMU-69478: G2/M DNA replication checkpoint
R-BTA-2142688: Synthesis of 5-eicosatetraenoic acids
R-MMU-446199: Synthesis of Dolichyl-phosphate
R-SSC-264876: Insulin processing
R-MMU-1237112: Methionine salvage pathway
R-HSA-196741: Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-3359462: Defective AMN causes hereditary megaloblastic anemia 1
R-HSA-3359463: Defective CUBN causes hereditary megaloblastic anemia 1
R-BTA-75153: Apoptotic execution phase
R-SSC-8963888: Chylomicron assembly
R-GGA-1296072: Voltage gated Potassium channels
R-BTA-4085001: Sialic acid metabolism
R-HSA-140180: COX reactions
R-RNO-197264: Nicotinamide salvaging
R-RNO-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-RNO-9018679: Biosynthesis of EPA-derived SPMs
R-RNO-9025094: Biosynthesis of DPAn-3 SPMs
R-RNO-9027604: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
R-BTA-156827: L13a-mediated translational silencing of Ceruloplasmin expression
R-BTA-72649: Translation initiation complex formation
R-BTA-72702: Ribosomal scanning and start codon recognition
R-MMU-75896: Plasmalogen biosynthesis
R-DDI-2395516: Electron transport from NADPH to Ferredoxin
R-HSA-189483: Heme degradation
R-SSC-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-SSC-879415: Advanced glycosylation endproduct receptor signaling
R-SSC-933542: TRAF6 mediated NF-kB activation
R-XTR-71403: Citric acid cycle (TCA cycle)
R-RNO-8964616: G beta:gamma signalling through CDC42
R-SCE-5694530: Cargo concentration in the ER
R-SCE-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-MMU-2142789: Ubiquinol biosynthesis
R-SSC-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-DRE-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-DRE-195253: Degradation of beta-catenin by the destruction complex
R-DRE-196299: Beta-catenin phosphorylation cascade
R-XTR-5423646: Aflatoxin activation and detoxification
R-XTR-189451: Heme biosynthesis
R-RNO-2142688: Synthesis of 5-eicosatetraenoic acids
R-BTA-163210: Formation of ATP by chemiosmotic coupling
R-BTA-8949613: Cristae formation
R-MMU-2122948: Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-193775: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-SPO-162658: Golgi Cisternae Pericentriolar Stack Reorganization
R-SPO-8873719: RAB geranylgeranylation
R-SPO-8876198: RAB GEFs exchange GTP for GDP on RABs
R-RNO-418990: Adherens junctions interactions
R-BTA-112308: Presynaptic depolarization and calcium channel opening
R-BTA-5576893: Phase 2 - plateau phase
R-RNO-1483191: Synthesis of PC
R-XTR-5687128: MAPK6/MAPK4 signaling
R-RNO-196757: Metabolism of folate and pterines
R-BTA-1296072: Voltage gated Potassium channels
R-RNO-75108: Activation, myristolyation of BID and translocation to mitochondria
R-MMU-193144: Estrogen biosynthesis
R-CFA-2142789: Ubiquinol biosynthesis
R-MMU-2485179: Activation of the phototransduction cascade
R-RNO-390522: Striated Muscle Contraction
R-MMU-373760: L1CAM interactions
R-DME-156711: Polo-like kinase mediated events
R-DME-69273: Cyclin A/B1/B2 associated events during G2/M transition
R-DME-69478: G2/M DNA replication checkpoint
R-MMU-1442490: Collagen degradation
R-MMU-216083: Integrin cell surface interactions
R-MMU-3000178: ECM proteoglycans
R-MMU-419037: NCAM1 interactions
R-MMU-8948216: Collagen chain trimerization
R-RNO-1237112: Methionine salvage pathway
R-HSA-5619107: Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-MMU-8847453: Synthesis of PIPs in the nucleus
R-HSA-3248023: Regulation by TREX1
R-DRE-8854521: Interaction between PHLDA1 and AURKA
R-CEL-204005: COPII-mediated vesicle transport
R-CEL-5694530: Cargo concentration in the ER
R-CEL-983170: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
R-MMU-6805567: Keratinization
R-MMU-6809371: Formation of the cornified envelope
R-SCE-8934903: Receptor Mediated Mitophagy
R-DRE-416993: Trafficking of GluR2-containing AMPA receptors
R-GGA-197264: Nicotinamide salvaging
R-GGA-2142770: Synthesis of 15-eicosatetraenoic acid derivatives
R-GGA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-GGA-9018679: Biosynthesis of EPA-derived SPMs
R-GGA-9025094: Biosynthesis of DPAn-3 SPMs
R-GGA-9027604: Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
R-GGA-75896: Plasmalogen biosynthesis
R-GGA-9033241: Peroxisomal protein import
R-MMU-200425: Import of palmitoyl-CoA into the mitochondrial matrix
R-MMU-8949664: Processing of SMDT1
R-MMU-1855183: Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-75896: Plasmalogen biosynthesis
R-HSA-4085001: Sialic acid metabolism
R-BTA-5576894: Phase 1 - inactivation of fast Na+ channels
R-CFA-75896: Plasmalogen biosynthesis
R-CFA-9033241: Peroxisomal protein import
R-SCE-70171: Glycolysis
R-MMU-70171: Glycolysis
R-MMU-189451: Heme biosynthesis
R-BTA-5205685: Pink/Parkin Mediated Mitophagy
R-BTA-8934903: Receptor Mediated Mitophagy
R-GGA-1237112: Methionine salvage pathway
R-DME-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-8849472: PTK6 Down-Regulation
R-BTA-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-RNO-201688: WNT mediated activation of DVL
R-RNO-4086400: PCP/CE pathway
R-MMU-190377: FGFR2b ligand binding and activation
R-DDI-1222556: ROS and RNS production in phagocytes
R-DDI-77387: Insulin receptor recycling
R-SCE-75153: Apoptotic execution phase
R-GGA-204626: Hypusine synthesis from eIF5A-lysine
R-DME-204626: Hypusine synthesis from eIF5A-lysine
R-RNO-3322077: Glycogen synthesis
R-CFA-166665: Terminal pathway of complement
R-CFA-6803157: Antimicrobial peptides
R-XTR-1660662: Glycosphingolipid metabolism
R-RNO-168638: NOD1/2 Signaling Pathway
R-RNO-937042: IRAK2 mediated activation of TAK1 complex
R-RNO-937072: TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-RNO-975163: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-DRE-5205685: Pink/Parkin Mediated Mitophagy
R-DRE-8934903: Receptor Mediated Mitophagy
R-CEL-389359: CD28 dependent Vav1 pathway
R-CEL-3928662: EPHB-mediated forward signaling
R-CEL-3928664: Ephrin signaling
R-CEL-5687128: MAPK6/MAPK4 signaling
R-HSA-1482798: Acyl chain remodeling of CL
R-SCE-189451: Heme biosynthesis
R-MMU-159418: Recycling of bile acids and salts
R-MMU-163560: Triglyceride catabolism
R-SSC-163210: Formation of ATP by chemiosmotic coupling
R-SSC-8949613: Cristae formation
R-RNO-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-BTA-170670: Adenylate cyclase inhibitory pathway
R-BTA-202040: G-protein activation
R-BTA-392170: ADP signalling through P2Y purinoceptor 12
R-BTA-400042: Adrenaline,noradrenaline inhibits insulin secretion
R-BTA-418990: Adherens junctions interactions
R-BTA-6805567: Keratinization
R-BTA-6809371: Formation of the cornified envelope
R-MMU-8857538: PTK6 promotes HIF1A stabilization
R-HSA-193993: Mineralocorticoid biosynthesis
R-HSA-194002: Glucocorticoid biosynthesis
R-HSA-5579021: Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
R-RNO-204626: Hypusine synthesis from eIF5A-lysine
R-SPO-2395516: Electron transport from NADPH to Ferredoxin
R-HSA-5578996: Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
R-SCE-1483213: Synthesis of PE
R-SCE-4419969: Depolymerisation of the Nuclear Lamina
R-SCE-75109: Triglyceride biosynthesis
R-MMU-446210: Synthesis of UDP-N-acetyl-glucosamine
R-RNO-111446: Activation of BIM and translocation to mitochondria
R-RNO-111453: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-BTA-196108: Pregnenolone biosynthesis
R-BTA-211976: Endogenous sterols
R-RNO-264870: Caspase-mediated cleavage of cytoskeletal proteins
R-XTR-196108: Pregnenolone biosynthesis
R-XTR-211976: Endogenous sterols
R-MMU-8963889: Assembly of active LPL and LIPC lipase complexes
R-GGA-5666185: RHO GTPases Activate Rhotekin and Rhophilins
R-SCE-2395516: Electron transport from NADPH to Ferredoxin
R-GGA-1227888: Negative Regulation of MDA5 signaling
R-XTR-373760: L1CAM interactions
R-DME-264870: Caspase-mediated cleavage of cytoskeletal proteins
R-DME-5223345: Miscellaneous transport and binding events
R-BTA-159418: Recycling of bile acids and salts
R-BTA-163560: Triglyceride catabolism
R-MMU-5624138: Trafficking of myristoylated proteins to the cilium
R-GGA-210991: Basigin interactions
R-SCE-141430: Inactivation of APC/C via direct inhibition of the APC/C complex
R-BTA-75896: Plasmalogen biosynthesis
R-SCE-70263: Gluconeogenesis
R-MMU-3322077: Glycogen synthesis
R-BTA-5652227: Fructose biosynthesis
R-CFA-202040: G-protein activation
R-CFA-2485179: Activation of the phototransduction cascade
R-CFA-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-CFA-6814122: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-RNO-77111: Synthesis of Ketone Bodies
R-HSA-112311: Neurotransmitter clearance
R-GGA-5652227: Fructose biosynthesis
R-GGA-5661270: Formation of xylulose-5-phosphate
R-GGA-165159: mTOR signalling
R-GGA-166208: mTORC1-mediated signalling
R-GGA-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-GGA-8943724: Regulation of PTEN gene transcription
R-GGA-2142789: Ubiquinol biosynthesis
R-HSA-5579013: Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
R-MMU-76005: Response to elevated platelet cytosolic Ca2+
R-MMU-2142700: Synthesis of Lipoxins (LX)
R-MMU-9018896: Biosynthesis of E-series 18(S)-resolvins
R-HSA-168275: Entry of Influenza Virion into Host Cell via Endocytosis
R-BTA-5624958: ARL13B-mediated ciliary trafficking of INPP5E
R-HSA-418359: Reduction of cytosolic Ca++ levels
R-HSA-425561: Sodium/Calcium exchangers
R-HSA-191273: Cholesterol biosynthesis
R-CEL-5689880: Ub-specific processing proteases
R-CEL-8948747: Regulation of PTEN localization
R-MMU-447043: Neurofascin interactions
R-RNO-75153: Apoptotic execution phase
R-HSA-111446: Activation of BIM and translocation to mitochondria
R-MMU-111446: Activation of BIM and translocation to mitochondria
R-GGA-1227986: Signaling by ERBB2
R-GGA-1251985: Nuclear signaling by ERBB4
R-GGA-177929: Signaling by EGFR
R-GGA-389356: CD28 co-stimulation
R-GGA-389513: CTLA4 inhibitory signaling
R-GGA-3928663: EPHA-mediated growth cone collapse
R-GGA-5663220: RHO GTPases Activate Formins
R-GGA-69231: Cyclin D associated events in G1
R-BTA-2485179: Activation of the phototransduction cascade
R-CFA-8873719: RAB geranylgeranylation
R-RNO-8849472: PTK6 Down-Regulation
R-MMU-210991: Basigin interactions
R-SCE-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-SCE-193993: Mineralocorticoid biosynthesis
R-MMU-8964616: G beta:gamma signalling through CDC42
R-RNO-2025928: Calcineurin activates NFAT
R-RNO-5607763: CLEC7A (Dectin-1) induces NFAT activation
R-MMU-1169091: Activation of NF-kappaB in B cells
R-MMU-4419969: Depolymerisation of the Nuclear Lamina
R-RNO-399956: CRMPs in Sema3A signaling
R-RNO-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-8935964: RUNX1 regulates expression of components of tight junctions
R-DME-6811440: Retrograde transport at the Trans-Golgi-Network
R-RNO-6785807: Interleukin-4 and Interleukin-13 signaling
R-RNO-6788467: IL-6-type cytokine receptor ligand interactions
R-RNO-8984722: Interleukin-35 Signalling
R-RNO-9020933: Interleukin-23 signaling
R-RNO-9020956: Interleukin-27 signaling
R-HSA-8942233: Intestinal infectious diseases
R-MMU-5627083: RHO GTPases regulate CFTR trafficking
R-MMU-947581: Molybdenum cofactor biosynthesis
R-HSA-164939: Nef mediated downregulation of CD28 cell surface expression
R-HSA-4341670: Defective NEU1 causes sialidosis
R-HSA-1482883: Acyl chain remodeling of DAG and TAG
R-HSA-426048: Arachidonate production from DAG
R-HSA-1237112: Methionine salvage pathway
R-HSA-5627083: RHO GTPases regulate CFTR trafficking
R-MMU-392154: Nitric oxide stimulates guanylate cyclase
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